U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Supratentorial Pleomorphic Xanthoastrocytoma

MedGen UID:
1660183
•Concept ID:
C4744526
•
Neoplastic Process

Definition

A pleomorphic xanthoastrocytoma that arises from the supratentorial region of the brain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSupratentorial Pleomorphic Xanthoastrocytoma

Professional guidelines

PubMed

Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424
Hub biomarkers for the diagnosis and treatment of glioblastoma based on microarray technology.
Cui K, Chen JH, Zou YF, Zhang SY, Wu B, Jing K, Li LW, Xia L, Sun C, Dong YL
Technol Cancer Res Treat 2021 Jan-Dec;20:1533033821990368. doi: 10.1177/1533033821990368. PMID: 34018447Free PMC Article
Thalamic Glioblastoma: Clinical Presentation, Management Strategies, and Outcomes.
Esquenazi Y, Moussazadeh N, Link TW, Hovinga KE, Reiner AS, DiStefano NM, Brennan C, Gutin P, Tabar V
Neurosurgery 2018 Jul 1;83(1):76-85. doi: 10.1093/neuros/nyx349. PMID: 28973417Free PMC Article

Recent clinical studies

Etiology

Adult Pilocytic Astrocytomas: A Brazilian Series.
Boschetti G, Santos AJ, Fermon KP, de Freitas Honório GL, Batistella G, Kusma SZ, Stávale JN, de Paiva Neto MA, Fleury Malheiros SM
World Neurosurg 2020 Jan;133:e115-e120. Epub 2019 Sep 21 doi: 10.1016/j.wneu.2019.08.146. PMID: 31550545
Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma.
She D, Liu J, Zeng Z, Xing Z, Cao D
Neuroradiology 2018 Jul;60(7):725-733. Epub 2018 May 24 doi: 10.1007/s00234-018-2036-y. PMID: 29797290Free PMC Article
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article
Pleomorphic xanthoastrocytoma of childhood: MR imaging and diffusion MR imaging features.
Moore W, Mathis D, Gargan L, Bowers DC, Klesse LJ, Margraf L, Koral K
AJNR Am J Neuroradiol 2014 Nov-Dec;35(11):2192-6. Epub 2014 Jul 3 doi: 10.3174/ajnr.A4011. PMID: 24994821Free PMC Article
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, Brandes AA, Hilton M, Abrey L, Cloughesy T
N Engl J Med 2014 Feb 20;370(8):709-22. doi: 10.1056/NEJMoa1308345. PMID: 24552318

Diagnosis

Pleomorphic xanthoastrocytoma, anaplastic pleomorphic xanthoastrocytoma, and epithelioid glioblastoma: Case series with clinical characteristics, molecular features and progression relationship.
Lin Z, Yang R, Zheng H, Li Z, Yi G, Wu Q, Yang C, Huang G
Clin Neurol Neurosurg 2022 Oct;221:107379. Epub 2022 Jul 21 doi: 10.1016/j.clineuro.2022.107379. PMID: 35932588
Supratentorial Tumors in Pediatric Patients.
Zamora C, Huisman TA, Izbudak I
Neuroimaging Clin N Am 2017 Feb;27(1):39-67. doi: 10.1016/j.nic.2016.08.003. PMID: 27889023
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article
High-grade gliomas in children.
Cage TA, Mueller S, Haas-Kogan D, Gupta N
Neurosurg Clin N Am 2012 Jul;23(3):515-23. Epub 2012 Jun 5 doi: 10.1016/j.nec.2012.04.007. PMID: 22748663
Rhabdoid glioblastoma.
Wyatt-Ashmead J, Kleinschmidt-DeMasters BK, Hill DA, Mierau GW, McGavran L, Thompson SJ, Foreman NK
Clin Neuropathol 2001 Nov-Dec;20(6):248-55. PMID: 11758780

Therapy

Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial.
Todo T, Ito H, Ino Y, Ohtsu H, Ota Y, Shibahara J, Tanaka M
Nat Med 2022 Aug;28(8):1630-1639. Epub 2022 Jul 21 doi: 10.1038/s41591-022-01897-x. PMID: 35864254Free PMC Article
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, Brandes AA, Hilton M, Abrey L, Cloughesy T
N Engl J Med 2014 Feb 20;370(8):709-22. doi: 10.1056/NEJMoa1308345. PMID: 24552318
High-grade gliomas in children.
Cage TA, Mueller S, Haas-Kogan D, Gupta N
Neurosurg Clin N Am 2012 Jul;23(3):515-23. Epub 2012 Jun 5 doi: 10.1016/j.nec.2012.04.007. PMID: 22748663
Pediatric glial tumors.
Cohen KJ, Broniscer A, Glod J
Curr Treat Options Oncol 2001 Dec;2(6):529-36. doi: 10.1007/s11864-001-0074-9. PMID: 12057098

Prognosis

Clinical characteristics and prognosis of Glioblastoma patients with infratentorial recurrence.
Kawauchi D, Ohno M, Honda-Kitahara M, Miyakita Y, Takahashi M, Yanagisawa S, Tamura Y, Kikuchi M, Ichimura K, Narita Y
BMC Neurol 2023 Jan 7;23(1):9. doi: 10.1186/s12883-022-03047-9. PMID: 36609238Free PMC Article
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Aggressive behavior and anaplasia in pleomorphic xanthoastrocytoma: a plea for a revision of the current WHO classification.
Kahramancetin N, Tihan T
CNS Oncol 2013 Nov;2(6):523-30. doi: 10.2217/cns.13.56. PMID: 25054822Free PMC Article
High-grade gliomas in children.
Cage TA, Mueller S, Haas-Kogan D, Gupta N
Neurosurg Clin N Am 2012 Jul;23(3):515-23. Epub 2012 Jun 5 doi: 10.1016/j.nec.2012.04.007. PMID: 22748663
Pediatric glial tumors.
Cohen KJ, Broniscer A, Glod J
Curr Treat Options Oncol 2001 Dec;2(6):529-36. doi: 10.1007/s11864-001-0074-9. PMID: 12057098

Clinical prediction guides

IDH-mutant diffuse gliomas: tips and tricks in the era of genomic tumor classification.
Ammendola S, Broggi G, Barresi V
Histol Histopathol 2023 Jul;38(7):739-753. Epub 2023 Jan 9 doi: 10.14670/HH-18-582. PMID: 36651583
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, Brandes AA, Hilton M, Abrey L, Cloughesy T
N Engl J Med 2014 Feb 20;370(8):709-22. doi: 10.1056/NEJMoa1308345. PMID: 24552318
Aggressive behavior and anaplasia in pleomorphic xanthoastrocytoma: a plea for a revision of the current WHO classification.
Kahramancetin N, Tihan T
CNS Oncol 2013 Nov;2(6):523-30. doi: 10.2217/cns.13.56. PMID: 25054822Free PMC Article
Congenital brain tumors.
Raisanen JM, Davis RL
Pathology (Phila) 1993;2(1):103-16. PMID: 9420933

Recent systematic reviews

The role of radiation therapy in treatment of adults with newly diagnosed glioblastoma multiforme: a systematic review and evidence-based clinical practice guideline update.
Ziu M, Kim BYS, Jiang W, Ryken T, Olson JJ
J Neurooncol 2020 Nov;150(2):215-267. Epub 2020 Nov 19 doi: 10.1007/s11060-020-03612-7. PMID: 33215344
Cytoreductive surgery in the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update.
Domino JS, Ormond DR, Germano IM, Sami M, Ryken TC, Olson JJ
J Neurooncol 2020 Nov;150(2):121-142. Epub 2020 Nov 19 doi: 10.1007/s11060-020-03606-5. PMID: 33215341
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...