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Abnormal glial cell morphology

MedGen UID:
867607
•Concept ID:
C4021993
•
Finding
Synonym: Abnormality of the glial cells
 
HPO: HP:0100705

Definition

An abnormality of the glia cell. [from HPO]

Professional guidelines

PubMed

Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797
Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article
Inflammatory demyelinating neuropathies and neuropathies associated with monoclonal gammopathies: treatment update.
Steck AJ, Czaplinski A, Renaud S
Neurotherapeutics 2008 Oct;5(4):528-34. doi: 10.1016/j.nurt.2008.08.012. PMID: 19019303Free PMC Article

Recent clinical studies

Etiology

Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P
Cell Stem Cell 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007. PMID: 35803230Free PMC Article
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes.
Jin X, Simmons SK, Guo A, Shetty AS, Ko M, Nguyen L, Jokhi V, Robinson E, Oyler P, Curry N, Deangeli G, Lodato S, Levin JZ, Regev A, Zhang F, Arlotta P
Science 2020 Nov 27;370(6520) doi: 10.1126/science.aaz6063. PMID: 33243861Free PMC Article
Glial cells in schizophrenia: a unified hypothesis.
Dietz AG, Goldman SA, Nedergaard M
Lancet Psychiatry 2020 Mar;7(3):272-281. Epub 2019 Nov 6 doi: 10.1016/S2215-0366(19)30302-5. PMID: 31704113Free PMC Article
Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J
Cell 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. PMID: 31675497
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes.
Nasrabady SE, Rizvi B, Goldman JE, Brickman AM
Acta Neuropathol Commun 2018 Mar 2;6(1):22. doi: 10.1186/s40478-018-0515-3. PMID: 29499767Free PMC Article

Diagnosis

Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review.
Park JC, Han SH, Mook-Jung I
BMB Rep 2020 Jan;53(1):10-19. doi: 10.5483/BMBRep.2020.53.1.309. PMID: 31865964Free PMC Article
Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.
Christian KM, Song H, Ming GL
Annu Rev Neurosci 2019 Jul 8;42:249-269. doi: 10.1146/annurev-neuro-080317-062231. PMID: 31283901Free PMC Article
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Central respiratory chemoreception.
Guyenet PG, Stornetta RL, Bayliss DA
J Comp Neurol 2010 Oct 1;518(19):3883-906. doi: 10.1002/cne.22435. PMID: 20737591Free PMC Article
Pelizaeus-Merzbacher disease.
Koeppen AH, Robitaille Y
J Neuropathol Exp Neurol 2002 Sep;61(9):747-59. doi: 10.1093/jnen/61.9.747. PMID: 12230321

Therapy

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
J Neuroinflammation 2021 Jun 11;18(1):131. doi: 10.1186/s12974-021-02182-3. PMID: 34116706Free PMC Article
Microglia in depression: current perspectives.
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Pinto B, Morelli G, Rastogi M, Savardi A, Fumagalli A, Petretto A, Bartolucci M, Varea E, Catelani T, Contestabile A, Perlini LE, Cancedda L
Neuron 2020 Dec 9;108(5):887-904.e12. Epub 2020 Oct 6 doi: 10.1016/j.neuron.2020.09.010. PMID: 33027640Free PMC Article
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797
Molecular dissection of reactive astrogliosis and glial scar formation.
Sofroniew MV
Trends Neurosci 2009 Dec;32(12):638-47. Epub 2009 Sep 24 doi: 10.1016/j.tins.2009.08.002. PMID: 19782411Free PMC Article

Prognosis

Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797
Glutamate uptake.
Danbolt NC
Prog Neurobiol 2001 Sep;65(1):1-105. doi: 10.1016/s0301-0082(00)00067-8. PMID: 11369436
Neonatal neoplasms.
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Clinical prediction guides

Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer's Disease.
Huang W, Xia Q, Zheng F, Zhao X, Ge F, Xiao J, Liu Z, Shen Y, Ye K, Wang D, Li Y
J Alzheimers Dis 2023;94(s1):S335-S354. doi: 10.3233/JAD-221064. PMID: 36683511Free PMC Article
Central nervous system diseases related to pathological microglial phagocytosis.
Wang K, Li J, Zhang Y, Huang Y, Chen D, Shi Z, Smith AD, Li W, Gao Y
CNS Neurosci Ther 2021 May;27(5):528-539. Epub 2021 Mar 2 doi: 10.1111/cns.13619. PMID: 33650762Free PMC Article
Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease.
Soret R, Schneider S, Bernas G, Christophers B, Souchkova O, Charrier B, Righini-Grunder F, Aspirot A, Landry M, Kembel SW, Faure C, Heuckeroth RO, Pilon N
Gastroenterology 2020 Nov;159(5):1824-1838.e17. Epub 2020 Jul 17 doi: 10.1053/j.gastro.2020.07.018. PMID: 32687927
Cellular and regional vulnerability in frontotemporal tauopathies.
Forrest SL, Kril JJ, Halliday GM
Acta Neuropathol 2019 Nov;138(5):705-727. Epub 2019 Jun 15 doi: 10.1007/s00401-019-02035-7. PMID: 31203391
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article

Recent systematic reviews

Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.
Yamamoto M, Sakai M, Yu Z, Nakanishi M, Yoshii H
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115750. PMID: 38891940Free PMC Article
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.
Hagbohm C, Ouellette R, Flanagan EP, Jonsson DI, Piehl F, Banwell B, Wickström R, Iacobaeus E, Granberg T, Ineichen BV
Eur J Neurol 2024 Jul;31(7):e16284. Epub 2024 Mar 20 doi: 10.1111/ene.16284. PMID: 38506182Free PMC Article
Brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS): new cases, systematic literature review, and associations with CSF1R-ALSP.
Dulski J, Souza J, Santos ML, Wszolek ZK
Orphanet J Rare Dis 2023 Jun 22;18(1):160. doi: 10.1186/s13023-023-02772-9. PMID: 37349768Free PMC Article
Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations.
Gouw AA, Seewann A, van der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJ
J Neurol Neurosurg Psychiatry 2011 Feb;82(2):126-35. Epub 2010 Oct 9 doi: 10.1136/jnnp.2009.204685. PMID: 20935330

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