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Metastatic Lung Adenocarcinoma

MedGen UID:
1660921
•Concept ID:
C4744444
•
Neoplastic Process

Definition

Lung adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lung Adenocarcinoma

Professional guidelines

PubMed

Utility of GATA3 in the differential diagnosis of pheochromocytoma.
Perrino CM, Ho A, Dall CP, Zynger DL
Histopathology 2017 Sep;71(3):475-479. Epub 2017 Jun 5 doi: 10.1111/his.13229. PMID: 28374498
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, Liu D, Ye X, Ye M, Yang J, Shao L, Pan H, Lu N, Yu Y, Liu L, Li J, Huang L, Tang H, Deng Q, Zheng Y, Peng L, Liu G, Gu X, He P, Gu Y, Lin W, He H, Xie G, Liang H, An N, Wang H, Teixeira M, Vieira J, Liang W, Zhao X, Peng Z, Mu F, Zhang X, Xu X, Yang H, Kristiansen K, Wang J, Zhong N, Wang J, Pan-Hammarström Q, He J
Nat Commun 2015 Dec 9;6:10131. doi: 10.1038/ncomms10131. PMID: 26647728Free PMC Article
Ceritinib for the treatment of late-stage (metastatic) non-small cell lung cancer.
Massarelli E, Papadimitrakopoulou V
Clin Cancer Res 2015 Feb 15;21(4):670-4. Epub 2015 Jan 6 doi: 10.1158/1078-0432.CCR-14-1291. PMID: 25564153

Recent clinical studies

Etiology

Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Unique Genetic Characteristics and Clinical Prognosis of Female Patients with Lung Cancer Harboring RET Fusion Gene.
Qiu Z, Ye B, Wang K, Zhou P, Zhao S, Li W, Tian P
Sci Rep 2020 Jun 25;10(1):10387. doi: 10.1038/s41598-020-66883-0. PMID: 32587276Free PMC Article
Metastatic cancer mimics interstitial lung disease. Cases when we need fast diagnosis and treatment.
Hecimovic A, Jakopovic M, Vukic Dugac A, Dzubur F, Samarzija M
Monaldi Arch Chest Dis 2019 Jun 4;89(2) doi: 10.4081/monaldi.2019.1041. PMID: 31162486
Safe and effective use of nivolumab for treating lung adenocarcinoma associated with sporadic lymphangioleiomyomatosis: a rare case report.
Pluvy J, Brosseau S, Stelianides S, Danel C, Nguenang M, Khalil A, Crestani B, Zalcman G, Gounant V
BMC Pulm Med 2019 Jan 11;19(1):12. doi: 10.1186/s12890-018-0775-5. PMID: 30634951Free PMC Article
Exploring the spatiotemporal genetic heterogeneity in metastatic lung adenocarcinoma using a nuclei flow-sorting approach.
Lorber T, Andor N, Dietsche T, Perrina V, Juskevicius D, Pereira K, Greer SU, Krause A, Müller DC, Savic Prince S, Lardinois D, Barrett MT, Ruiz C, Bubendorf L
J Pathol 2019 Feb;247(2):199-213. Epub 2018 Dec 28 doi: 10.1002/path.5183. PMID: 30350422

Diagnosis

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.
Kim N, Kim HK, Lee K, Hong Y, Cho JH, Choi JW, Lee JI, Suh YL, Ku BM, Eum HH, Choi S, Choi YL, Joung JG, Park WY, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ, Lee HO
Nat Commun 2020 May 8;11(1):2285. doi: 10.1038/s41467-020-16164-1. PMID: 32385277Free PMC Article
Metastatic cancer mimics interstitial lung disease. Cases when we need fast diagnosis and treatment.
Hecimovic A, Jakopovic M, Vukic Dugac A, Dzubur F, Samarzija M
Monaldi Arch Chest Dis 2019 Jun 4;89(2) doi: 10.4081/monaldi.2019.1041. PMID: 31162486
Utility of GATA3 in the differential diagnosis of pheochromocytoma.
Perrino CM, Ho A, Dall CP, Zynger DL
Histopathology 2017 Sep;71(3):475-479. Epub 2017 Jun 5 doi: 10.1111/his.13229. PMID: 28374498
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article
EGFR and KRAS mutations in metastatic lung adenocarcinomas.
Munfus-McCray D, Harada S, Adams C, Askin F, Clark D, Gabrielson E, Li QK
Hum Pathol 2011 Oct;42(10):1447-53. Epub 2011 Apr 15 doi: 10.1016/j.humpath.2010.12.011. PMID: 21497370

Therapy

Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Prognostic factors and survival prediction for patients with metastatic lung adenocarcinoma: A population-based study.
Wu B, Chen J, Zhang X, Feng N, Xiang Z, Wei Y, Xie J, Zhang W
Medicine (Baltimore) 2022 Dec 9;101(49):e32217. doi: 10.1097/MD.0000000000032217. PMID: 36626448Free PMC Article
Utilization and costs of epidermal growth factor receptor mutation testing and targeted therapy in Medicare patients with metastatic lung adenocarcinoma.
Shen C, Holguin RAP, Schaefer E, Zhou S, Belani CP, Ma PC, Reed MF
BMC Health Serv Res 2022 Apr 9;22(1):470. doi: 10.1186/s12913-022-07857-y. PMID: 35397521Free PMC Article
A user's guide to lorlatinib.
Nagasaka M, Ge Y, Sukari A, Kukreja G, Ou SI
Crit Rev Oncol Hematol 2020 Jul;151:102969. Epub 2020 May 11 doi: 10.1016/j.critrevonc.2020.102969. PMID: 32416346
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.
Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, Mok T, Geater SL, Orlov S, Tsai CM, Boyer M, Su WC, Bennouna J, Kato T, Gorbunova V, Lee KH, Shah R, Massey D, Zazulina V, Shahidi M, Schuler M
J Clin Oncol 2013 Sep 20;31(27):3327-34. Epub 2013 Jul 1 doi: 10.1200/JCO.2012.44.2806. PMID: 23816960

Prognosis

m(6) A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis.
Yang X, Bai Q, Chen W, Liang J, Wang F, Gu W, Liu L, Li Q, Chen Z, Zhou A, Long J, Tian H, Wu J, Ding X, Zhou N, Li M, Yang Y, Cai J
Adv Sci (Weinh) 2023 Jul;10(20):e2206744. Epub 2023 May 12 doi: 10.1002/advs.202206744. PMID: 37171793Free PMC Article
Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Prognostic factors and survival prediction for patients with metastatic lung adenocarcinoma: A population-based study.
Wu B, Chen J, Zhang X, Feng N, Xiang Z, Wei Y, Xie J, Zhang W
Medicine (Baltimore) 2022 Dec 9;101(49):e32217. doi: 10.1097/MD.0000000000032217. PMID: 36626448Free PMC Article
Unique Genetic Characteristics and Clinical Prognosis of Female Patients with Lung Cancer Harboring RET Fusion Gene.
Qiu Z, Ye B, Wang K, Zhou P, Zhao S, Li W, Tian P
Sci Rep 2020 Jun 25;10(1):10387. doi: 10.1038/s41598-020-66883-0. PMID: 32587276Free PMC Article
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article

Clinical prediction guides

A Misleading Case of NTRK-Rearranged Papillary Thyroid Carcinoma.
Germani MM, Boccaccio C, Matrone A, Molinaro E, Alì G, Giordano M, Elisei R, Fontanini G, Cremolini C
Oncologist 2024 Jan 5;29(1):84-88. doi: 10.1093/oncolo/oyad310. PMID: 38037189Free PMC Article
Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Detection of EGFR mutations in plasma circulating tumour DNA as a selection criterion for first-line gefitinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): a phase 2, single-arm, multicentre clinical trial.
Wang Z, Cheng Y, An T, Gao H, Wang K, Zhou Q, Hu Y, Song Y, Ding C, Peng F, Liang L, Hu Y, Huang C, Zhou C, Shi Y, Zhang L, Ye X, Zhang M, Chuai S, Zhu G, Hu J, Wu YL, Wang J
Lancet Respir Med 2018 Sep;6(9):681-690. Epub 2018 Jul 17 doi: 10.1016/S2213-2600(18)30264-9. PMID: 30017884
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article
Transplantation of "high-risk" donor hearts: Implications for infection.
Gaffey AC, Doll SL, Thomasson AM, Venkataraman C, Chen CW, Goldberg LR, Blumberg EA, Acker MA, Stone F, Atluri P
J Thorac Cardiovasc Surg 2016 Jul;152(1):213-20. Epub 2016 Jan 22 doi: 10.1016/j.jtcvs.2015.12.062. PMID: 26898978

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