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Advanced Lung Adenocarcinoma

MedGen UID:
1786216
•Concept ID:
C5447399
•
Neoplastic Process

Definition

Lung adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Lung Adenocarcinoma

Professional guidelines

PubMed

The treatment of advanced lung adenocarcinoma with activating EGFR mutations.
Rocco D, Della Gravara L, Battiloro C, Maione P, Gridelli C
Expert Opin Pharmacother 2021 Dec;22(18):2475-2482. Epub 2021 Jul 22 doi: 10.1080/14656566.2021.1957096. PMID: 34281457
New treatment options for lung adenocarcinoma--in view of molecular background.
Bittner N, Ostoros G, Géczi L
Pathol Oncol Res 2014 Jan;20(1):11-25. Epub 2013 Dec 5 doi: 10.1007/s12253-013-9719-9. PMID: 24306880
First-line management of EGFR-mutated advanced lung adenocarcinoma: recent developments.
Liao BC, Lin CC, Yang JC
Drugs 2013 Mar;73(4):357-69. doi: 10.1007/s40265-013-0020-8. PMID: 23479407

Recent clinical studies

Etiology

Single-cell RNA-sequencing uncovers the dynamic changes of tumour immune microenvironment in advanced lung adenocarcinoma.
Lu H, Qian J, Cheng L, Shen Y, Chu T, Zhao C
BMJ Open Respir Res 2023 Dec 11;10(1) doi: 10.1136/bmjresp-2023-001878. PMID: 38081768Free PMC Article
Evaluation of KRAS Concomitant Mutations in Advanced Lung Adenocarcinoma Patients.
Aran V, Zalis M, Montella T, de Sousa CAM, Ferrari BL, Gil Ferreira C
Medicina (Kaunas) 2021 Sep 29;57(10) doi: 10.3390/medicina57101039. PMID: 34684076Free PMC Article
Efficacy of Osimertinib Plus Bevacizumab vs Osimertinib in Patients With EGFR T790M-Mutated Non-Small Cell Lung Cancer Previously Treated With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor: West Japan Oncology Group 8715L Phase 2 Randomized Clinical Trial.
Akamatsu H, Toi Y, Hayashi H, Fujimoto D, Tachihara M, Furuya N, Otani S, Shimizu J, Katakami N, Azuma K, Miura N, Nishino K, Hara S, Teraoka S, Morita S, Nakagawa K, Yamamoto N
JAMA Oncol 2021 Mar 1;7(3):386-394. doi: 10.1001/jamaoncol.2020.6758. PMID: 33410885Free PMC Article
Distribution of molecular subtypes of advanced lung adenocarcinoma and clinical outcomes in a center of Argentina.
Recondo G Jr, Denninghoff V, Cuello MT, Lorente C, Greco M, De la Vega M, Avagnina A, Recondo G
Medicina (B Aires) 2018;78(6):385-394. PMID: 30504104
A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER).
Shi Y, Au JS, Thongprasert S, Srinivasan S, Tsai CM, Khoa MT, Heeroma K, Itoh Y, Cornelio G, Yang PC
J Thorac Oncol 2014 Feb;9(2):154-62. doi: 10.1097/JTO.0000000000000033. PMID: 24419411Free PMC Article

Diagnosis

Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.
Kim SY, Kim SM, Lim S, Lee JY, Choi SJ, Yang SD, Yun MR, Kim CG, Gu SR, Park C, Park AY, Lim SM, Heo SG, Kim H, Cho BC
Clin Cancer Res 2021 Aug 1;27(15):4397-4409. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-5026. PMID: 34083237Free PMC Article
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts.
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling.
Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X, Li L
Int J Cancer 2018 Aug 15;143(4):931-943. Epub 2018 Mar 25 doi: 10.1002/ijc.31357. PMID: 29516506
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Therapy

Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.
Kim SY, Kim SM, Lim S, Lee JY, Choi SJ, Yang SD, Yun MR, Kim CG, Gu SR, Park C, Park AY, Lim SM, Heo SG, Kim H, Cho BC
Clin Cancer Res 2021 Aug 1;27(15):4397-4409. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-5026. PMID: 34083237Free PMC Article
Efficacy of Osimertinib Plus Bevacizumab vs Osimertinib in Patients With EGFR T790M-Mutated Non-Small Cell Lung Cancer Previously Treated With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor: West Japan Oncology Group 8715L Phase 2 Randomized Clinical Trial.
Akamatsu H, Toi Y, Hayashi H, Fujimoto D, Tachihara M, Furuya N, Otani S, Shimizu J, Katakami N, Azuma K, Miura N, Nishino K, Hara S, Teraoka S, Morita S, Nakagawa K, Yamamoto N
JAMA Oncol 2021 Mar 1;7(3):386-394. doi: 10.1001/jamaoncol.2020.6758. PMID: 33410885Free PMC Article
Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.
Kim SY, Lee JY, Kim DH, Joo H-, Yun MR, Jung D, Yun J, Heo SG, Ahn B-, Park CW, Pyo KH, Chun YJ, Hong MH, Kim HR, Cho BC
Sci Rep 2019 Dec 27;9(1):19909. doi: 10.1038/s41598-019-56356-4. PMID: 31882684Free PMC Article
HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib.
Wang Y, Jiang T, Qin Z, Jiang J, Wang Q, Yang S, Rivard C, Gao G, Ng TL, Tu MM, Yu H, Ji H, Zhou C, Ren S, Zhang J, Bunn P, Doebele RC, Camidge DR, Hirsch FR
Ann Oncol 2019 Mar 1;30(3):447-455. doi: 10.1093/annonc/mdy542. PMID: 30596880Free PMC Article
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.
Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, Mok T, Geater SL, Orlov S, Tsai CM, Boyer M, Su WC, Bennouna J, Kato T, Gorbunova V, Lee KH, Shah R, Massey D, Zazulina V, Shahidi M, Schuler M
J Clin Oncol 2013 Sep 20;31(27):3327-34. Epub 2013 Jul 1 doi: 10.1200/JCO.2012.44.2806. PMID: 23816960

Prognosis

Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.
Kim SY, Kim SM, Lim S, Lee JY, Choi SJ, Yang SD, Yun MR, Kim CG, Gu SR, Park C, Park AY, Lim SM, Heo SG, Kim H, Cho BC
Clin Cancer Res 2021 Aug 1;27(15):4397-4409. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-5026. PMID: 34083237Free PMC Article
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts.
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling.
Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X, Li L
Int J Cancer 2018 Aug 15;143(4):931-943. Epub 2018 Mar 25 doi: 10.1002/ijc.31357. PMID: 29516506
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.
Kim SY, Kim SM, Lim S, Lee JY, Choi SJ, Yang SD, Yun MR, Kim CG, Gu SR, Park C, Park AY, Lim SM, Heo SG, Kim H, Cho BC
Clin Cancer Res 2021 Aug 1;27(15):4397-4409. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-5026. PMID: 34083237Free PMC Article
IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling.
Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X, Li L
Int J Cancer 2018 Aug 15;143(4):931-943. Epub 2018 Mar 25 doi: 10.1002/ijc.31357. PMID: 29516506
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article
A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER).
Shi Y, Au JS, Thongprasert S, Srinivasan S, Tsai CM, Khoa MT, Heeroma K, Itoh Y, Cornelio G, Yang PC
J Thorac Oncol 2014 Feb;9(2):154-62. doi: 10.1097/JTO.0000000000000033. PMID: 24419411Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

Anal Metastasis from Lung Cancer: Report of a Case and Systematic Review of the Literature.
Bardac OD, Baciu AB, Bogdan-Duică IS
Chirurgia (Bucur) 2020 Sept-Oct;115(5):681-689. doi: 10.21614/chirurgia.115.5.681. PMID: 33138907
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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