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Refractory Polymorphic Post-Transplant Lymphoproliferative Disorder

MedGen UID:
1682220
•Concept ID:
C4763648
•
Neoplastic Process

Definition

A polymorphic post-transplant lymphoproliferative disorder that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Polymorphic Post-Transplant Lymphoproliferative Disorder

Recent clinical studies

Etiology

Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center.
Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H
Pediatr Transplant 2022 Aug;26(5):e14268. Epub 2022 Mar 19 doi: 10.1111/petr.14268. PMID: 35304794
CD30 expression and survival in posttransplant lymphoproliferative disorders.
Kinch A, Amini RM, Hollander P, Molin D, Sundström C, Enblad G
Acta Oncol 2020 Jun;59(6):673-680. Epub 2020 Feb 27 doi: 10.1080/0284186X.2020.1731924. PMID: 32102582
Post-transplant lymphoproliferative disease (PTLD): Pharmacological, virological and other determinants.
Stojanova J, Caillard S, Rousseau A, Marquet P
Pharmacol Res 2011 Jan;63(1):1-7. Epub 2010 Nov 4 doi: 10.1016/j.phrs.2010.10.016. PMID: 21056103
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

Diagnosis

Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center.
Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H
Pediatr Transplant 2022 Aug;26(5):e14268. Epub 2022 Mar 19 doi: 10.1111/petr.14268. PMID: 35304794
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397
Renal allograft involvement by Epstein-Barr virus associated post-transplant lymphoproliferative disease.
Randhawa PS, Magnone M, Jordan M, Shapiro R, Demetris AJ, Nalesnik M
Am J Surg Pathol 1996 May;20(5):563-71. doi: 10.1097/00000478-199605000-00003. PMID: 8619421

Therapy

Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center.
Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H
Pediatr Transplant 2022 Aug;26(5):e14268. Epub 2022 Mar 19 doi: 10.1111/petr.14268. PMID: 35304794
CD30 expression and survival in posttransplant lymphoproliferative disorders.
Kinch A, Amini RM, Hollander P, Molin D, Sundström C, Enblad G
Acta Oncol 2020 Jun;59(6):673-680. Epub 2020 Feb 27 doi: 10.1080/0284186X.2020.1731924. PMID: 32102582
Post-transplant lymphoproliferative disease (PTLD): Pharmacological, virological and other determinants.
Stojanova J, Caillard S, Rousseau A, Marquet P
Pharmacol Res 2011 Jan;63(1):1-7. Epub 2010 Nov 4 doi: 10.1016/j.phrs.2010.10.016. PMID: 21056103
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

Prognosis

Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

Clinical prediction guides

Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

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