U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased proportion of CD4+CD25+ regulatory T cells

MedGen UID:
1687349
•Concept ID:
C5139085
•
Finding
Synonyms: Elevated proportion of CD4+CD25+ regulatory T cells; Increased proportion of CD4+CD25+ Treg cells
 
HPO: HP:0020112

Definition

An abnormally increased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of CD4+CD25+ regulatory T cells

Professional guidelines

PubMed

The characteristic profiles of PD-1 and PD-L1 expressions and dynamic changes during treatment in active tuberculosis.
Shen L, Shi H, Gao Y, Ou Q, Liu Q, Liu Y, Wu J, Zhang W, Fan L, Shao L
Tuberculosis (Edinb) 2016 Dec;101:146-150. Epub 2016 Oct 1 doi: 10.1016/j.tube.2016.10.001. PMID: 27865385
Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment.
Bresson D, Fousteri G, Manenkova Y, Croft M, von Herrath M
J Autoimmun 2011 Dec;37(4):342-51. Epub 2011 Nov 6 doi: 10.1016/j.jaut.2011.10.001. PMID: 22063316Free PMC Article
Increased CD4+CD25+Foxp3+ T cells in peripheral blood of celiac disease patients: correlation with dietary treatment.
Frisullo G, Nociti V, Iorio R, Patanella AK, Marti A, Assunta B, Plantone D, Cammarota G, Tonali PA, Batocchi AP
Hum Immunol 2009 Jun;70(6):430-5. Epub 2009 Apr 11 doi: 10.1016/j.humimm.2009.04.006. PMID: 19364517

Recent clinical studies

Etiology

Phenotypes of regulatory T cells in different stages of COPD.
Alves LHV, Ito JT, Almeida FM, Oliveira LM, Stelmach R, Tibério LFLC, Sato MN, Lopes FDTQS
Int Immunopharmacol 2024 Oct 25;140:112765. Epub 2024 Jul 30 doi: 10.1016/j.intimp.2024.112765. PMID: 39083931
Effect of sevoflurane on CD4+CD25+FOXP3+ regulatory T cells in patients with gastric cancer undergoing radical surgery.
Yong F, Wang H, Li C, Liu W, Wang Z, Jia H
Cell Mol Biol (Noisy-le-grand) 2023 Aug 31;69(8):214-220. doi: 10.14715/cmb/2023.69.8.33. PMID: 37715379
SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4(+)CD25(+) Regulatory T Cells.
Li YY, Lin YK, Li Y, Liu XH, Li DJ, Wang XL, Wang L, Zhu YZ, Yu M, Du MR
Int J Biol Sci 2022;18(5):1961-1973. Epub 2022 Feb 21 doi: 10.7150/ijbs.68224. PMID: 35342349Free PMC Article
Evaluation of Exhausted Regulatory T Cells in Preeclampsia.
Daraei N, Ghafourian M, Ghadiri A, Amari A, Najafian M, Rokhafrooz S
Iran J Immunol 2019 Jun;16(2):163-169. doi: 10.22034/IJI.2019.80259. PMID: 31182690
Increased proportion of CD4(+)CD25(+)Foxp3(+) regulatory T cells during early-stage sepsis in ICU patients.
Leng FY, Liu JL, Liu ZJ, Yin JY, Qu HP
J Microbiol Immunol Infect 2013 Oct;46(5):338-44. Epub 2012 Aug 24 doi: 10.1016/j.jmii.2012.06.012. PMID: 22921804

Diagnosis

Blood immune cell profiling in adults with longstanding type 1 diabetes is associated with macrovascular complications.
He X, Wang X, van Heck J, van Cranenbroek B, van Rijssen E, Stienstra R, Netea MG, Joosten I, Tack CJ, Koenen HJPM
Front Immunol 2024;15:1401542. Epub 2024 Jul 1 doi: 10.3389/fimmu.2024.1401542. PMID: 39011037Free PMC Article
Decreased Absolute Number of Circulating Regulatory T Cells in Patients With Takayasu's Arteritis.
Jia W, Fu ZL, Wang X, Luo J, Yan CL, Cao JP, Yan-Liu, Xie JF, Liu GY, Gao C, Li XF
Front Immunol 2021;12:768244. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.768244. PMID: 35006213Free PMC Article
The Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis: A Meta-Analysis.
Lai NL, Zhang SX, Wang J, Zhang JQ, Wang CH, Gao C, Li XF
J Immunol Res 2019;2019:1058738. Epub 2019 Oct 23 doi: 10.1155/2019/1058738. PMID: 31772947Free PMC Article
Increased activated regulatory T cells proportion correlate with the severity of idiopathic pulmonary fibrosis.
Hou Z, Ye Q, Qiu M, Hao Y, Han J, Zeng H
Respir Res 2017 Sep 8;18(1):170. doi: 10.1186/s12931-017-0653-3. PMID: 28886713Free PMC Article
Increased proportion of CD4(+)CD25(+)Foxp3(+) regulatory T cells during early-stage sepsis in ICU patients.
Leng FY, Liu JL, Liu ZJ, Yin JY, Qu HP
J Microbiol Immunol Infect 2013 Oct;46(5):338-44. Epub 2012 Aug 24 doi: 10.1016/j.jmii.2012.06.012. PMID: 22921804

Therapy

Effect of sevoflurane on CD4+CD25+FOXP3+ regulatory T cells in patients with gastric cancer undergoing radical surgery.
Yong F, Wang H, Li C, Liu W, Wang Z, Jia H
Cell Mol Biol (Noisy-le-grand) 2023 Aug 31;69(8):214-220. doi: 10.14715/cmb/2023.69.8.33. PMID: 37715379
Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer.
Ma Y, Li J, Wang H, Chiu Y, Kingsley CV, Fry D, Delaney SN, Wei SC, Zhang J, Maitra A, Yee C
Gastroenterology 2020 Jul;159(1):306-319.e12. Epub 2020 Mar 14 doi: 10.1053/j.gastro.2020.03.018. PMID: 32179091Free PMC Article
The Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis: A Meta-Analysis.
Lai NL, Zhang SX, Wang J, Zhang JQ, Wang CH, Gao C, Li XF
J Immunol Res 2019;2019:1058738. Epub 2019 Oct 23 doi: 10.1155/2019/1058738. PMID: 31772947Free PMC Article
Modulation of regulatory T cells by natural products in cancer.
Bahrami A, Fereidouni M, Pirro M, Bianconi V, Sahebkar A
Cancer Lett 2019 Sep 10;459:72-85. Epub 2019 Jun 6 doi: 10.1016/j.canlet.2019.06.001. PMID: 31176742
Immunogene therapy.
Lichtor T, Glick RP
Adv Exp Med Biol 2012;746:151-65. doi: 10.1007/978-1-4614-3146-6_12. PMID: 22639166

Prognosis

TIM-4 increases the proportion of CD4(+)CD25(+)FOXP3(+) regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL-6 secretion.
Wang Z, Xie Z, Mou Y, Geng R, Chen C, Ke N
Cancer Med 2024 Sep;13(17):e70110. doi: 10.1002/cam4.70110. PMID: 39235042Free PMC Article
Effect of sevoflurane on CD4+CD25+FOXP3+ regulatory T cells in patients with gastric cancer undergoing radical surgery.
Yong F, Wang H, Li C, Liu W, Wang Z, Jia H
Cell Mol Biol (Noisy-le-grand) 2023 Aug 31;69(8):214-220. doi: 10.14715/cmb/2023.69.8.33. PMID: 37715379
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Lin L, Chen S, Wang H, Gao B, Kallakury B, Bhuvaneshwar K, Cahn K, Gusev Y, Wang X, Wu Y, Marshall JL, Zhi X, He AR
Theranostics 2021;11(9):4232-4250. Epub 2021 Feb 20 doi: 10.7150/thno.49819. PMID: 33754058Free PMC Article
Modulation of regulatory T cells by natural products in cancer.
Bahrami A, Fereidouni M, Pirro M, Bianconi V, Sahebkar A
Cancer Lett 2019 Sep 10;459:72-85. Epub 2019 Jun 6 doi: 10.1016/j.canlet.2019.06.001. PMID: 31176742

Clinical prediction guides

TIM-4 increases the proportion of CD4(+)CD25(+)FOXP3(+) regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL-6 secretion.
Wang Z, Xie Z, Mou Y, Geng R, Chen C, Ke N
Cancer Med 2024 Sep;13(17):e70110. doi: 10.1002/cam4.70110. PMID: 39235042Free PMC Article
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Lin L, Chen S, Wang H, Gao B, Kallakury B, Bhuvaneshwar K, Cahn K, Gusev Y, Wang X, Wu Y, Marshall JL, Zhi X, He AR
Theranostics 2021;11(9):4232-4250. Epub 2021 Feb 20 doi: 10.7150/thno.49819. PMID: 33754058Free PMC Article
The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus.
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L
Cell Mol Immunol 2017 May;14(5):423-431. Epub 2015 Oct 5 doi: 10.1038/cmi.2015.89. PMID: 26435067Free PMC Article
CD4+/CD25(high)/FoxP3+/CD127- regulatory T cells in bronchoalveolar lavage fluid of lung cancer patients.
Osińska I, Stelmaszczyk-Emmel A, Polubiec-Kownacka M, Dziedzic D, Domagała-Kulawik J
Hum Immunol 2016 Oct;77(10):912-915. Epub 2016 Jul 27 doi: 10.1016/j.humimm.2016.07.235. PMID: 27474372

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...