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HbC hemoglobin

MedGen UID:
1688191
•Concept ID:
C4759912
•
Finding
Synonyms: Haemoglobin C; HbC haemoglobin; Hemoglobin C
 
HPO: HP:0032146

Definition

Presence of an abnormal type of hemoglobin characterized by the substitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHbC hemoglobin

Professional guidelines

PubMed

Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels.
Oxendine Harp K, Bashi A, Botchway F, Addo-Gyan D, Tetteh-Tsifoanya M, Lamptey A, Djameh G, Iqbal SA, Lekpor C, Banerjee S, Wilson MD, Dei-Adomakoh Y, Adjei AA, Stiles JK, Driss A
Int J Mol Sci 2023 Apr 19;24(8) doi: 10.3390/ijms24087546. PMID: 37108709Free PMC Article
Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection.
Harp KO, Botchway F, Dei-Adomakoh Y, Wilson MD, Hood JL, Adjei AA, Stiles JK, Driss A
Front Immunol 2020;11:593546. Epub 2020 Dec 23 doi: 10.3389/fimmu.2020.593546. PMID: 33424841Free PMC Article
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article

Recent clinical studies

Etiology

Platelet count and MCHC as independent prognostic markers for feline mammary carcinomas.
da Silva Soares E, Rocha CC, Valente FL, Dos Anjos LRA, de Oliveira FLD, de Oliveira Loures C, Rocha PT, Castro VR, Sarandy TB, Borges APB
Res Vet Sci 2023 Nov;164:105024. Epub 2023 Sep 19 doi: 10.1016/j.rvsc.2023.105024. PMID: 37827061
Investigating the potential of packed cell volume for deducing hemoglobin: Cholistani camels in perspective.
Farooq U, Idris M, Sajjad N, Lashari MH, Ahmad S, Rehman ZU, Rashid H, Mahmood A, Hameed S
PLoS One 2023;18(5):e0280659. Epub 2023 May 16 doi: 10.1371/journal.pone.0280659. PMID: 37192212Free PMC Article
G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria.
Thiam F, Diop G, Coulonges C, Derbois C, Mbengue B, Thiam A, Nguer CM, Zagury JF, Deleuze JF, Dieye A
PeerJ 2022;10:e13487. Epub 2022 Jul 5 doi: 10.7717/peerj.13487. PMID: 35811813Free PMC Article
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article
A review of variant hemoglobins interfering with hemoglobin A1c measurement.
Little RR, Roberts WL
J Diabetes Sci Technol 2009 May 1;3(3):446-51. doi: 10.1177/193229680900300307. PMID: 20144281Free PMC Article

Diagnosis

Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels.
Oxendine Harp K, Bashi A, Botchway F, Addo-Gyan D, Tetteh-Tsifoanya M, Lamptey A, Djameh G, Iqbal SA, Lekpor C, Banerjee S, Wilson MD, Dei-Adomakoh Y, Adjei AA, Stiles JK, Driss A
Int J Mol Sci 2023 Apr 19;24(8) doi: 10.3390/ijms24087546. PMID: 37108709Free PMC Article
Hemoglobin Nanocrystals for Drugs Free, Synergistic Theranostics of Colon Tumor.
Zhou R, Xu H, Qu J, Ohulchanskyy TY
Small 2023 Feb;19(8):e2205165. Epub 2022 Dec 12 doi: 10.1002/smll.202205165. PMID: 36508710
Epidemiological and molecular study of hemoglobinopathies in Mauritanian patients.
Mahmoud T, Sahli C, Hadj Fredj S, Amri Y, Othmani R, Mohamed GS, Zein E, Messaoud T
Mol Genet Genomic Med 2022 Oct;10(10):e2048. Epub 2022 Sep 15 doi: 10.1002/mgg3.2048. PMID: 36106931Free PMC Article
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article
An update on electrophoretic and chromatographic methods in the diagnosis of hemoglobinopathies.
Basset P, Braconnier F, Rosa J
J Chromatogr 1982 Feb 12;227(2):267-304. doi: 10.1016/s0378-4347(00)80384-9. PMID: 7037806

Therapy

Most adults with severe HbSC disease are not treated with hydroxyurea.
Ghunney WK, Asare EV, Ayete-Nyampong JB, Oppong SA, Rodeghier M, DeBaun MR, Olayemi E
Blood Adv 2023 Jul 11;7(13):3312-3319. doi: 10.1182/bloodadvances.2022009049. PMID: 36799926Free PMC Article
HbA1c performs well in monitoring glucose control even in populations with high prevalence of medical conditions that may alter its reliability: the OPTIMAL observational multicenter study.
Niwaha AJ, Rodgers LR, Greiner R, Balungi PA, Mwebaze R, McDonald TJ, Hattersley AT, Shields BM, Nyirenda MJ, Jones AG
BMJ Open Diabetes Res Care 2021 Sep;9(1) doi: 10.1136/bmjdrc-2021-002350. PMID: 34535465Free PMC Article
Voxelotor Treatment Interferes With Quantitative and Qualitative Hemoglobin Variant Analysis in Multiple Sickle Cell Disease Genotypes.
Rutherford-Parker NJ, Campbell ST, Colby JM, Shajani-Yi Z
Am J Clin Pathol 2020 Oct 13;154(5):627-634. doi: 10.1093/ajcp/aqaa067. PMID: 32561909
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article
β-globin gene cluster haplotypes in sickle cell patients from Panamá.
Rusanova I, Cossio G, Moreno B, Javier Perea F, De Borace RG, Perea M, Escames G, Acuña-Castroviejo D
Am J Hum Biol 2011 May-Jun;23(3):377-80. Epub 2011 Mar 8 doi: 10.1002/ajhb.21148. PMID: 21387457

Prognosis

Platelet count and MCHC as independent prognostic markers for feline mammary carcinomas.
da Silva Soares E, Rocha CC, Valente FL, Dos Anjos LRA, de Oliveira FLD, de Oliveira Loures C, Rocha PT, Castro VR, Sarandy TB, Borges APB
Res Vet Sci 2023 Nov;164:105024. Epub 2023 Sep 19 doi: 10.1016/j.rvsc.2023.105024. PMID: 37827061
Investigating the potential of packed cell volume for deducing hemoglobin: Cholistani camels in perspective.
Farooq U, Idris M, Sajjad N, Lashari MH, Ahmad S, Rehman ZU, Rashid H, Mahmood A, Hameed S
PLoS One 2023;18(5):e0280659. Epub 2023 May 16 doi: 10.1371/journal.pone.0280659. PMID: 37192212Free PMC Article
Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels.
Oxendine Harp K, Bashi A, Botchway F, Addo-Gyan D, Tetteh-Tsifoanya M, Lamptey A, Djameh G, Iqbal SA, Lekpor C, Banerjee S, Wilson MD, Dei-Adomakoh Y, Adjei AA, Stiles JK, Driss A
Int J Mol Sci 2023 Apr 19;24(8) doi: 10.3390/ijms24087546. PMID: 37108709Free PMC Article
G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria.
Thiam F, Diop G, Coulonges C, Derbois C, Mbengue B, Thiam A, Nguer CM, Zagury JF, Deleuze JF, Dieye A
PeerJ 2022;10:e13487. Epub 2022 Jul 5 doi: 10.7717/peerj.13487. PMID: 35811813Free PMC Article
The distribution of haemoglobin C and its prevalence in newborns in Africa.
Piel FB, Howes RE, Patil AP, Nyangiri OA, Gething PW, Bhatt S, Williams TN, Weatherall DJ, Hay SI
Sci Rep 2013;3:1671. doi: 10.1038/srep01671. PMID: 23591685Free PMC Article

Clinical prediction guides

Prediction of anemia in real-time using a smartphone camera processing conjunctival images.
Zhao L, Vidwans A, Bearnot CJ, Rayner J, Lin T, Baird J, Suner S, Jay GD
PLoS One 2024;19(5):e0302883. Epub 2024 May 13 doi: 10.1371/journal.pone.0302883. PMID: 38739605Free PMC Article
Platelet count and MCHC as independent prognostic markers for feline mammary carcinomas.
da Silva Soares E, Rocha CC, Valente FL, Dos Anjos LRA, de Oliveira FLD, de Oliveira Loures C, Rocha PT, Castro VR, Sarandy TB, Borges APB
Res Vet Sci 2023 Nov;164:105024. Epub 2023 Sep 19 doi: 10.1016/j.rvsc.2023.105024. PMID: 37827061
Investigating the potential of packed cell volume for deducing hemoglobin: Cholistani camels in perspective.
Farooq U, Idris M, Sajjad N, Lashari MH, Ahmad S, Rehman ZU, Rashid H, Mahmood A, Hameed S
PLoS One 2023;18(5):e0280659. Epub 2023 May 16 doi: 10.1371/journal.pone.0280659. PMID: 37192212Free PMC Article
Evaluation of hemoglobin A1c measurement by Capillarys 2 electrophoresis for detection of abnormal glucose tolerance in African immigrants to the United States.
Zhao Z, Basilio J, Hanson S, Little RR, Sumner AE, Sacks DB
Clin Chim Acta 2015 Jun 15;446:54-60. Epub 2015 Apr 8 doi: 10.1016/j.cca.2015.03.025. PMID: 25861848Free PMC Article
Flexibility and nucleation in sickle hemoglobin.
Ivanova M, Jasuja R, Krasnosselskaia L, Josephs R, Wang Z, Ding M, Horiuchi K, Adachi K, Ferrone FA
J Mol Biol 2001 Dec 7;314(4):851-61. doi: 10.1006/jmbi.2001.5163. PMID: 11734002

Recent systematic reviews

Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review.
Jacobs JW, Sharma D, Stephens LD, Figueroa Villalba CA, Rinder HM, Woo JS, Wheeler AP, Gerberi D, Goel R, Tormey CA, Booth GS, Bloch EM, Adkins BD
Br J Haematol 2024 Apr;204(4):1500-1506. Epub 2024 Jan 30 doi: 10.1111/bjh.19313. PMID: 38291731
Herbal Drug use in Sickle Cell Disease Management; Trends and Perspectives in Sub-Saharan Africa - A Systematic Review.
Okoh MP, Alli LA, Tolvanen MEE, Nwegbu MM
Curr Drug Discov Technol 2019;16(4):372-385. doi: 10.2174/1570163815666181002101611. PMID: 30277160

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