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Abnormal hemoglobin

MedGen UID:
776552
•Concept ID:
C0349705
•
Finding
Synonyms: Abnormal haemoglobin; Abnormal Hb
 
HPO: HP:0011902

Definition

Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. [from HPO]

Professional guidelines

PubMed

Understanding Sickle cell disease: Causes, symptoms, and treatment options.
Elendu C, Amaechi DC, Alakwe-Ojimba CE, Elendu TC, Elendu RC, Ayabazu CP, Aina TO, Aborisade O, Adenikinju JS
Medicine (Baltimore) 2023 Sep 22;102(38):e35237. doi: 10.1097/MD.0000000000035237. PMID: 37746969Free PMC Article
Sickle Cell Disease and Thromboembolism: New Insights on the Pathophysiology, Diagnosis, and Treatment.
Dobie G
Clin Lab 2023 Jul 1;69(7) doi: 10.7754/Clin.Lab.2023.221006. PMID: 37436376
SC411 treatment can enhance survival in a mouse model of sickle cell disease.
Wu CYC, Lopez-Toledano MA, Daak AA, Clemons GA, Citadin CT, Sancilio FD, Rabinowicz AL, Minagar A, Neumann JT, Lee RHC, Lin HW
Prostaglandins Leukot Essent Fatty Acids 2020 Jul;158:102110. Epub 2020 May 3 doi: 10.1016/j.plefa.2020.102110. PMID: 32447175

Recent clinical studies

Etiology

Hypercoagulability in Sickle Cell Disease: A Thrombo-Inflammatory Mechanism.
Hamali HA
Hemoglobin 2023 Nov;47(6):205-214. Epub 2024 Jan 22 doi: 10.1080/03630269.2023.2301026. PMID: 38189099
Vascular pathophysiology of sickle cell disease.
Connes P, Renoux C, Joly P, Nader E
Presse Med 2023 Dec;52(4):104202. Epub 2023 Nov 7 doi: 10.1016/j.lpm.2023.104202. PMID: 37944640
Cardiovascular complications of sickle cell disease.
Sachdev V, Rosing DR, Thein SL
Trends Cardiovasc Med 2021 Apr;31(3):187-193. Epub 2020 Feb 11 doi: 10.1016/j.tcm.2020.02.002. PMID: 32139143Free PMC Article
The Red Blood Cell-Inflammation Vicious Circle in Sickle Cell Disease.
Nader E, Romana M, Connes P
Front Immunol 2020;11:454. Epub 2020 Mar 13 doi: 10.3389/fimmu.2020.00454. PMID: 32231672Free PMC Article
Erythrocyte and platelet proteomics in hematological disorders.
Chakrabarti A, Halder S, Karmakar S
Proteomics Clin Appl 2016 Apr;10(4):403-14. Epub 2016 Jan 28 doi: 10.1002/prca.201500080. PMID: 26611378

Diagnosis

Understanding Sickle cell disease: Causes, symptoms, and treatment options.
Elendu C, Amaechi DC, Alakwe-Ojimba CE, Elendu TC, Elendu RC, Ayabazu CP, Aina TO, Aborisade O, Adenikinju JS
Medicine (Baltimore) 2023 Sep 22;102(38):e35237. doi: 10.1097/MD.0000000000035237. PMID: 37746969Free PMC Article
Cardiovascular complications of sickle cell disease.
Sachdev V, Rosing DR, Thein SL
Trends Cardiovasc Med 2021 Apr;31(3):187-193. Epub 2020 Feb 11 doi: 10.1016/j.tcm.2020.02.002. PMID: 32139143Free PMC Article
The Red Blood Cell-Inflammation Vicious Circle in Sickle Cell Disease.
Nader E, Romana M, Connes P
Front Immunol 2020;11:454. Epub 2020 Mar 13 doi: 10.3389/fimmu.2020.00454. PMID: 32231672Free PMC Article
Erythrocyte and platelet proteomics in hematological disorders.
Chakrabarti A, Halder S, Karmakar S
Proteomics Clin Appl 2016 Apr;10(4):403-14. Epub 2016 Jan 28 doi: 10.1002/prca.201500080. PMID: 26611378
Methemoglobinemia.
Mansouri A
Am J Med Sci 1985 May;289(5):200-9. doi: 10.1097/00000441-198505000-00004. PMID: 4003427

Therapy

Current and Future Therapeutics for Treating Patients with Sickle Cell Disease.
Barak M, Hu C, Matthews A, Fortenberry YM
Cells 2024 May 16;13(10) doi: 10.3390/cells13100848. PMID: 38786070Free PMC Article
An innovative intervention for the prevention of vaso-occlusive episodes in sickle cell disease.
Jeon WJ, Joung B, Moon JH, Hino C, Park D, Pham B, Castillo DR, Chong E, Kaur S, Grismore C, Cao H
Hematology 2023 Dec;28(1):2215575. doi: 10.1080/16078454.2023.2215575. PMID: 37227254
How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life.
Merlet AN, Chatel B, Hourdé C, Ravelojaona M, Bendahan D, Féasson L, Messonnier LA
Med Sci Sports Exerc 2019 Jan;51(1):4-11. doi: 10.1249/MSS.0000000000001757. PMID: 30095751
Inflammatory targets of therapy in sickle cell disease.
Owusu-Ansah A, Ihunnah CA, Walker AL, Ofori-Acquah SF
Transl Res 2016 Jan;167(1):281-97. Epub 2015 Jul 11 doi: 10.1016/j.trsl.2015.07.001. PMID: 26226206Free PMC Article
Methemoglobinemia.
Mansouri A
Am J Med Sci 1985 May;289(5):200-9. doi: 10.1097/00000441-198505000-00004. PMID: 4003427

Prognosis

A Clinical Risk Model for Surgical Site Infection Following Pediatric Spine Deformity Surgery.
Matsumoto H, Larson EL, Warren SI, Hammoor BT, Bonsignore-Opp L, Troy MJ, Barrett KK, Striano BM, Li G, Terry MB, Roye BD, Lenke LG, Skaggs DL, Glotzbecker MP, Flynn JM, Roye DP, Vitale MG
J Bone Joint Surg Am 2022 Feb 16;104(4):364-375. doi: 10.2106/JBJS.21.00751. PMID: 34851324
Cardiovascular complications of sickle cell disease.
Sachdev V, Rosing DR, Thein SL
Trends Cardiovasc Med 2021 Apr;31(3):187-193. Epub 2020 Feb 11 doi: 10.1016/j.tcm.2020.02.002. PMID: 32139143Free PMC Article
Predictors of hospital readmission among older adults with cancer.
Burhenn P, Sun CL, Scher KS, Hsu J, Pandya P, Chui CY, Arsenyan A, Mitani D, Morrison R, Katheria V, Hurria A
J Geriatr Oncol 2020 Sep;11(7):1108-1114. Epub 2020 Mar 25 doi: 10.1016/j.jgo.2020.03.008. PMID: 32222347Free PMC Article
Epidemiology of sickle cell disease in Saudi Arabia.
Jastaniah W
Ann Saudi Med 2011 May-Jun;31(3):289-93. doi: 10.4103/0256-4947.81540. PMID: 21623060Free PMC Article
Overview of pathophysiology and rationale for treatment of sickle cell anemia.
Rodgers GP
Semin Hematol 1997 Jul;34(3 Suppl 3):2-7. PMID: 9317195

Clinical prediction guides

Associations between HbA1c-derived estimated average glucose and fasting plasma glucose in patients with normal and abnormal hemoglobin patterns.
Sriwimol W, Choosongsang P, Choosongsang P, Petkliang W, Treerut P
Scand J Clin Lab Invest 2022 May;82(3):192-198. Epub 2022 Feb 17 doi: 10.1080/00365513.2022.2040051. PMID: 35175156
A Clinical Risk Model for Surgical Site Infection Following Pediatric Spine Deformity Surgery.
Matsumoto H, Larson EL, Warren SI, Hammoor BT, Bonsignore-Opp L, Troy MJ, Barrett KK, Striano BM, Li G, Terry MB, Roye BD, Lenke LG, Skaggs DL, Glotzbecker MP, Flynn JM, Roye DP, Vitale MG
J Bone Joint Surg Am 2022 Feb 16;104(4):364-375. doi: 10.2106/JBJS.21.00751. PMID: 34851324
Predictors of hospital readmission among older adults with cancer.
Burhenn P, Sun CL, Scher KS, Hsu J, Pandya P, Chui CY, Arsenyan A, Mitani D, Morrison R, Katheria V, Hurria A
J Geriatr Oncol 2020 Sep;11(7):1108-1114. Epub 2020 Mar 25 doi: 10.1016/j.jgo.2020.03.008. PMID: 32222347Free PMC Article
How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life.
Merlet AN, Chatel B, Hourdé C, Ravelojaona M, Bendahan D, Féasson L, Messonnier LA
Med Sci Sports Exerc 2019 Jan;51(1):4-11. doi: 10.1249/MSS.0000000000001757. PMID: 30095751
Beta-thalassemia in Turkey.
Oner R, Altay C, Gurgey A, Aksoy M, Kilinç Y, Stoming TA, Reese AL, Kutlar A, Kutlar F, Huisman TH
Hemoglobin 1990;14(1):1-13. doi: 10.3109/03630269009002250. PMID: 2200760

Recent systematic reviews

Hydroxyurea can be used in children with sickle cell disease and cerebral vasculopathy for the prevention of chronic complications? A meta-analysis.
Núñez RM, Figueroa CAP, García-Perdomo HA
J Child Health Care 2020 Mar;24(1):64-77. Epub 2019 Jan 3 doi: 10.1177/1367493518814922. PMID: 30606035
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2018 Nov 16;11(11):CD007652. doi: 10.1002/14651858.CD007652.pub6. PMID: 30480767Free PMC Article
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2016 Nov 14;11:CD007652. doi: 10.1002/14651858.CD007652.pub5. PMID: 27841932
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2014 Oct 10;(10):CD007652. doi: 10.1002/14651858.CD007652.pub4. PMID: 25300171
Gene therapy for sickle cell disease.
Olowoyeye A, Okwundu CI
Cochrane Database Syst Rev 2012 Nov 14;11:CD007652. doi: 10.1002/14651858.CD007652.pub3. PMID: 23152248

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