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Advanced Gastroesophageal Junction Adenocarcinoma

MedGen UID:
1689127
•Concept ID:
C5204519
•
Neoplastic Process

Definition

Gastroesophageal junction adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Gastroesophageal Junction Adenocarcinoma

Professional guidelines

PubMed

Tislelizumab plus chemotherapy is an optimal option for second-line treatment for advanced gastroesophageal junction adenocarcinoma.
Yang P, Pan T, Wang MK, Xiao MS, Zhang S, Liu S
Anticancer Drugs 2024 Aug 1;35(7):666-671. Epub 2024 Mar 22 doi: 10.1097/CAD.0000000000001607. PMID: 38527277

Recent clinical studies

Etiology

Tislelizumab plus chemotherapy is an optimal option for second-line treatment for advanced gastroesophageal junction adenocarcinoma.
Yang P, Pan T, Wang MK, Xiao MS, Zhang S, Liu S
Anticancer Drugs 2024 Aug 1;35(7):666-671. Epub 2024 Mar 22 doi: 10.1097/CAD.0000000000001607. PMID: 38527277

Diagnosis

Lymph node involvement in advanced gastroesophageal junction adenocarcinoma.
Pedrazzani C, de Manzoni G, Marrelli D, Giacopuzzi S, Corso G, Minicozzi AM, Rampone B, Roviello F
J Thorac Cardiovasc Surg 2007 Aug;134(2):378-85. doi: 10.1016/j.jtcvs.2007.03.034. PMID: 17662776

Therapy

Tislelizumab plus chemotherapy is an optimal option for second-line treatment for advanced gastroesophageal junction adenocarcinoma.
Yang P, Pan T, Wang MK, Xiao MS, Zhang S, Liu S
Anticancer Drugs 2024 Aug 1;35(7):666-671. Epub 2024 Mar 22 doi: 10.1097/CAD.0000000000001607. PMID: 38527277
FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma.
Sahin U, Türeci Ö, Manikhas G, Lordick F, Rusyn A, Vynnychenko I, Dudov A, Bazin I, Bondarenko I, Melichar B, Dhaene K, Wiechen K, Huber C, Maurus D, Arozullah A, Park JW, Schuler M, Al-Batran SE
Ann Oncol 2021 May;32(5):609-619. Epub 2021 Feb 19 doi: 10.1016/j.annonc.2021.02.005. PMID: 33610734
MAHOGANY: margetuximab combination in HER2+ unresectable/metastatic gastric/gastroesophageal junction adenocarcinoma.
Catenacci DV, Rosales M, Chung HC, H Yoon H, Shen L, Moehler M, Kang YK
Future Oncol 2021 Apr;17(10):1155-1164. Epub 2020 Dec 2 doi: 10.2217/fon-2020-1007. PMID: 33263418

Prognosis

Tislelizumab plus chemotherapy is an optimal option for second-line treatment for advanced gastroesophageal junction adenocarcinoma.
Yang P, Pan T, Wang MK, Xiao MS, Zhang S, Liu S
Anticancer Drugs 2024 Aug 1;35(7):666-671. Epub 2024 Mar 22 doi: 10.1097/CAD.0000000000001607. PMID: 38527277
Lymph node involvement in advanced gastroesophageal junction adenocarcinoma.
Pedrazzani C, de Manzoni G, Marrelli D, Giacopuzzi S, Corso G, Minicozzi AM, Rampone B, Roviello F
J Thorac Cardiovasc Surg 2007 Aug;134(2):378-85. doi: 10.1016/j.jtcvs.2007.03.034. PMID: 17662776

Clinical prediction guides

Tislelizumab plus chemotherapy is an optimal option for second-line treatment for advanced gastroesophageal junction adenocarcinoma.
Yang P, Pan T, Wang MK, Xiao MS, Zhang S, Liu S
Anticancer Drugs 2024 Aug 1;35(7):666-671. Epub 2024 Mar 22 doi: 10.1097/CAD.0000000000001607. PMID: 38527277
FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma.
Sahin U, Türeci Ö, Manikhas G, Lordick F, Rusyn A, Vynnychenko I, Dudov A, Bazin I, Bondarenko I, Melichar B, Dhaene K, Wiechen K, Huber C, Maurus D, Arozullah A, Park JW, Schuler M, Al-Batran SE
Ann Oncol 2021 May;32(5):609-619. Epub 2021 Feb 19 doi: 10.1016/j.annonc.2021.02.005. PMID: 33610734

Supplemental Content

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