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Abnormal urine protein level

MedGen UID:
1694967
•Concept ID:
C5209228
•
Finding
HPO: HP:0020129

Definition

Any deviation of the concentration of one or more proteins in the urine. [from HPO]

Professional guidelines

PubMed

Diagnosis and Management of Multiple Myeloma: A Review.
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, Tuazon S, Gopal AK, Libby EN
JAMA 2022 Feb 1;327(5):464-477. doi: 10.1001/jama.2022.0003. PMID: 35103762
Epidemiology, Staging, and Management of Multiple Myeloma.
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article
Multiple Myeloma: Diagnosis and Treatment.
Michels TC, Petersen KE
Am Fam Physician 2017 Mar 15;95(6):373-383. PMID: 28318212

Recent clinical studies

Etiology

Genetically proxied low-density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations.
Ardissino M, Slob EAW, Reddy RK, Morley AP, Schuermans A, Hill P, Williamson C, Honigberg MC, de Marvao A, Ng FS
Eur J Prev Cardiol 2024 Jun 3;31(8):955-965. doi: 10.1093/eurjpc/zwad402. PMID: 38294056Free PMC Article
Biochemical profile of Bence-Jones type multiple myeloma.
Lyubimova NV, Timofeev YS, Abaev VM, Votyakova OM, Osmanov EA, Kushlinskii NE
Klin Lab Diagn 2022 Oct 14;67(10):570-574. doi: 10.51620/0869-2084-2022-67-10-570-574. PMID: 36315171
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.
Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L
EBioMedicine 2015 Aug;2(8):968-84. Epub 2015 Jul 10 doi: 10.1016/j.ebiom.2015.07.007. PMID: 26425705Free PMC Article
Testing for albuminuria in 2014.
McFarlane PA
Can J Diabetes 2014 Oct;38(5):372-5. doi: 10.1016/j.jcjd.2014.07.221. PMID: 25284700

Diagnosis

Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders.
Rana S, Burke SD, Karumanchi SA
Am J Obstet Gynecol 2022 Feb;226(2S):S1019-S1034. Epub 2020 Oct 20 doi: 10.1016/j.ajog.2020.10.022. PMID: 33096092Free PMC Article
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Diseases associated with calcium-sensing receptor.
Vahe C, Benomar K, Espiard S, Coppin L, Jannin A, Odou MF, Vantyghem MC
Orphanet J Rare Dis 2017 Jan 25;12(1):19. doi: 10.1186/s13023-017-0570-z. PMID: 28122587Free PMC Article
Alpha-fetoprotein: a review.
Crandall BF
Crit Rev Clin Lab Sci 1981;15(2):127-85. doi: 10.3109/10408368109105870. PMID: 6169490

Therapy

Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.
Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L
EBioMedicine 2015 Aug;2(8):968-84. Epub 2015 Jul 10 doi: 10.1016/j.ebiom.2015.07.007. PMID: 26425705Free PMC Article
Formaldehyde stress.
He R, Lu J, Miao J
Sci China Life Sci 2010 Dec;53(12):1399-404. Epub 2010 Dec 23 doi: 10.1007/s11427-010-4112-3. PMID: 21181340
Rhabdomyolysis.
Bagley WH, Yang H, Shah KH
Intern Emerg Med 2007 Oct;2(3):210-8. Epub 2007 Oct 1 doi: 10.1007/s11739-007-0060-8. PMID: 17909702

Prognosis

Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Du X, Yang L, Kong L, Sun Y, Shen K, Cai Y, Sun H, Zhang B, Guo S, Zhang A, Wang X
Front Endocrinol (Lausanne) 2022;13:1037164. Epub 2022 Oct 27 doi: 10.3389/fendo.2022.1037164. PMID: 36387907Free PMC Article
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Rhabdomyolysis: a review of the literature.
Khan FY
Neth J Med 2009 Oct;67(9):272-83. PMID: 19841484
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Clinical prediction guides

Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders.
Rana S, Burke SD, Karumanchi SA
Am J Obstet Gynecol 2022 Feb;226(2S):S1019-S1034. Epub 2020 Oct 20 doi: 10.1016/j.ajog.2020.10.022. PMID: 33096092Free PMC Article
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Recent systematic reviews

Kidney Function, Albuminuria, and Risk of Incident Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Ha JT, Freedman SB, Kelly DM, Neuen BL, Perkovic V, Jun M, Badve SV
Am J Kidney Dis 2024 Mar;83(3):350-359.e1. Epub 2023 Sep 29 doi: 10.1053/j.ajkd.2023.07.023. PMID: 37777059
Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies.
Cárdenas MC, García-Sanz R, Puig N, Pérez-Surribas D, Flores-Montero J, Ortiz-Espejo M, de la Rubia J, Cruz-Iglesias E
Clin Chem Lab Med 2023 Nov 27;61(12):2115-2130. Epub 2023 Jul 24 doi: 10.1515/cclm-2023-0326. PMID: 37477188
Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis.
Rompianesi G, Hann A, Komolafe O, Pereira SP, Davidson BR, Gurusamy KS
Cochrane Database Syst Rev 2017 Apr 21;4(4):CD012010. doi: 10.1002/14651858.CD012010.pub2. PMID: 28431198Free PMC Article
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Urine tests for Down's syndrome screening.
Alldred SK, Guo B, Takwoingi Y, Pennant M, Wisniewski S, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2015 Dec 10;2015(12):CD011984. doi: 10.1002/14651858.CD011984. PMID: 26662198Free PMC Article

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