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Gluten allergy

MedGen UID:
1698538
•Concept ID:
C5139492
•
Pathologic Function
Synonyms: Allergy to gluten; IgE-mediated gluten allergy; Immunoglobulin E-mediated gluten allergy
SNOMED CT: Allergy to gluten (1269425007)
 
HPO: HP:0410329

Definition

Hypersensitivity in form of an adverse immune reaction against gluten. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGluten allergy

Professional guidelines

PubMed

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.
DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796
AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
ESPEN guideline on hospital nutrition.
Thibault R, Abbasoglu O, Ioannou E, Meija L, Ottens-Oussoren K, Pichard C, Rothenberg E, Rubin D, Siljamäki-Ojansuu U, Vaillant MF, Bischoff SC
Clin Nutr 2021 Dec;40(12):5684-5709. Epub 2021 Oct 20 doi: 10.1016/j.clnu.2021.09.039. PMID: 34742138

Recent clinical studies

Etiology

The Nutritional Quality of Gluten-Free versus Non-Gluten-Free Pre-Packaged Foods and Beverages Sold in Hong Kong.
Ho CKW, Tjhin A, Barrett E, Coyle DH, Wu JHY, Louie JCY
Ann Nutr Metab 2023;79(3):301-312. Epub 2023 Jun 7 doi: 10.1159/000530857. PMID: 37285813
Intestinal microenvironment-mediated allergic dynamic phenotypes and endotypes in the development of gluten allergy.
Xie Q, Liu C, Fu W, Chen C, Gu S, Luo D, Xue W
Food Res Int 2023 Jul;169:112840. Epub 2023 Apr 17 doi: 10.1016/j.foodres.2023.112840. PMID: 37254413
Recent strategies for tackling the problems in gluten-free diet and products.
Demirkesen I, Ozkaya B
Crit Rev Food Sci Nutr 2022;62(3):571-597. Epub 2020 Sep 28 doi: 10.1080/10408398.2020.1823814. PMID: 32981341
Gluten related illnesses and severe mental disorders: a comprehensive review.
Brietzke E, Cerqueira RO, Mansur RB, McIntyre RS
Neurosci Biobehav Rev 2018 Jan;84:368-375. Epub 2017 Aug 19 doi: 10.1016/j.neubiorev.2017.08.009. PMID: 28830676
Coeliac disease and gluten avoidance in New Zealand children.
Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, Crane J, Camargo CA Jr; New Zealand Asthma and Allergy Cohort Study Group
Arch Dis Child 2012 Jan;97(1):12-6. Epub 2011 Nov 10 doi: 10.1136/archdischild-2011-300248. PMID: 22075107

Diagnosis

The Nutritional Quality of Gluten-Free versus Non-Gluten-Free Pre-Packaged Foods and Beverages Sold in Hong Kong.
Ho CKW, Tjhin A, Barrett E, Coyle DH, Wu JHY, Louie JCY
Ann Nutr Metab 2023;79(3):301-312. Epub 2023 Jun 7 doi: 10.1159/000530857. PMID: 37285813
Recent strategies for tackling the problems in gluten-free diet and products.
Demirkesen I, Ozkaya B
Crit Rev Food Sci Nutr 2022;62(3):571-597. Epub 2020 Sep 28 doi: 10.1080/10408398.2020.1823814. PMID: 32981341
Amylase-Trypsin Inhibitors in Wheat and Other Cereals as Potential Activators of the Effects of Nonceliac Gluten Sensitivity.
Reig-Otero Y, Mañes J, Manyes L
J Med Food 2018 Mar;21(3):207-214. Epub 2018 Jan 9 doi: 10.1089/jmf.2017.0018. PMID: 29315017
Gluten-Related Disorders: Celiac Disease, Gluten Allergy, Non-Celiac Gluten Sensitivity.
Allen PJ
Pediatr Nurs 2015 May-Jun;41(3):146-50. PMID: 26201175
Coeliac disease and gluten avoidance in New Zealand children.
Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, Crane J, Camargo CA Jr; New Zealand Asthma and Allergy Cohort Study Group
Arch Dis Child 2012 Jan;97(1):12-6. Epub 2011 Nov 10 doi: 10.1136/archdischild-2011-300248. PMID: 22075107

Therapy

Intestinal microenvironment-mediated allergic dynamic phenotypes and endotypes in the development of gluten allergy.
Xie Q, Liu C, Fu W, Chen C, Gu S, Luo D, Xue W
Food Res Int 2023 Jul;169:112840. Epub 2023 Apr 17 doi: 10.1016/j.foodres.2023.112840. PMID: 37254413
Amylase-Trypsin Inhibitors in Wheat and Other Cereals as Potential Activators of the Effects of Nonceliac Gluten Sensitivity.
Reig-Otero Y, Mañes J, Manyes L
J Med Food 2018 Mar;21(3):207-214. Epub 2018 Jan 9 doi: 10.1089/jmf.2017.0018. PMID: 29315017
Gluten related illnesses and severe mental disorders: a comprehensive review.
Brietzke E, Cerqueira RO, Mansur RB, McIntyre RS
Neurosci Biobehav Rev 2018 Jan;84:368-375. Epub 2017 Aug 19 doi: 10.1016/j.neubiorev.2017.08.009. PMID: 28830676
Interleukin 15 and CD4⁺ T cells cooperate to promote small intestinal enteropathy in response to dietary antigen.
Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N
Gastroenterology 2014 Apr;146(4):1017-27. Epub 2013 Dec 18 doi: 10.1053/j.gastro.2013.12.023. PMID: 24361466
A case of MRSA controlled: predisposing factors and immune stimulation.
Lamson DW, Sadlon AE
Altern Med Rev 2010 Jul;15(2):147-51. PMID: 20806999

Prognosis

Utility of testing patients, on presentation, for serologic features of celiac disease.
Srinivas M, Basumani P, Podmore G, Shrimpton A, Bardhan KD
Clin Gastroenterol Hepatol 2014 Jun;12(6):946-52. Epub 2013 Nov 19 doi: 10.1016/j.cgh.2013.10.037. PMID: 24262940
Coeliac disease and gluten avoidance in New Zealand children.
Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, Crane J, Camargo CA Jr; New Zealand Asthma and Allergy Cohort Study Group
Arch Dis Child 2012 Jan;97(1):12-6. Epub 2011 Nov 10 doi: 10.1136/archdischild-2011-300248. PMID: 22075107

Clinical prediction guides

Detection of Sensitization Profiles with Cellular In Vitro Tests in Wheat Allergy Dependent on Augmentation Factors (WALDA).
Faihs V, Schmalhofer V, Kugler C, Bent RK, Scherf KA, Lexhaller B, Mortz CG, Bindslev-Jensen C, Biedermann T, Skov PS, Eberlein B, Brockow K
Int J Mol Sci 2024 Mar 22;25(7) doi: 10.3390/ijms25073574. PMID: 38612386Free PMC Article
The Nutritional Quality of Gluten-Free versus Non-Gluten-Free Pre-Packaged Foods and Beverages Sold in Hong Kong.
Ho CKW, Tjhin A, Barrett E, Coyle DH, Wu JHY, Louie JCY
Ann Nutr Metab 2023;79(3):301-312. Epub 2023 Jun 7 doi: 10.1159/000530857. PMID: 37285813
Interleukin 15 and CD4⁺ T cells cooperate to promote small intestinal enteropathy in response to dietary antigen.
Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N
Gastroenterology 2014 Apr;146(4):1017-27. Epub 2013 Dec 18 doi: 10.1053/j.gastro.2013.12.023. PMID: 24361466
Utility of testing patients, on presentation, for serologic features of celiac disease.
Srinivas M, Basumani P, Podmore G, Shrimpton A, Bardhan KD
Clin Gastroenterol Hepatol 2014 Jun;12(6):946-52. Epub 2013 Nov 19 doi: 10.1016/j.cgh.2013.10.037. PMID: 24262940
Coeliac disease and gluten avoidance in New Zealand children.
Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, Crane J, Camargo CA Jr; New Zealand Asthma and Allergy Cohort Study Group
Arch Dis Child 2012 Jan;97(1):12-6. Epub 2011 Nov 10 doi: 10.1136/archdischild-2011-300248. PMID: 22075107

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