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Reduced plasma cell count

MedGen UID:
1702663
•Concept ID:
C5139089
•
Finding
HPO: HP:0025618

Definition

An abnormally low number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced plasma cell count

Professional guidelines

PubMed

Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange.
Kühne L, Knöbl P, Eller K, Thaler J, Sperr WR, Gleixner K, Osterholt T, Kaufeld J, Menne J, Buxhofer-Ausch V, Mühlfeld A, Seelow E, Schreiber A, Todorova P, Cukoski S, Jabs WJ, Özcan F, Gäckler A, Schönfelder K, Seibert FS, Westhoff T, Schwenger V, Eichenauer DA, Völker LA, Brinkkoetter PT
Blood 2024 Oct 3;144(14):1486-1495. doi: 10.1182/blood.2023023780. PMID: 38838300
Advances in the management of TTP.
Subhan M, Scully M
Blood Rev 2022 Sep;55:100945. Epub 2022 Feb 17 doi: 10.1016/j.blre.2022.100945. PMID: 35216839
Coagulopathy management in liver transplantation.
Sabate A, Dalmau A, Koo M, Aparicio I, Costa M, Contreras L
Transplant Proc 2012 Jul-Aug;44(6):1523-5. doi: 10.1016/j.transproceed.2012.05.004. PMID: 22841202

Recent clinical studies

Etiology

Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis.
Shen HH, Zhang YY, Wang XY, Wang CJ, Wang Y, Ye JF, Li MQ
Biomolecules 2024 Jan 16;14(1) doi: 10.3390/biom14010116. PMID: 38254716Free PMC Article
Teclistamab impairs humoral immunity in patients with heavily pretreated myeloma: importance of immunoglobulin supplementation.
Frerichs KA, Verkleij CPM, Mateos MV, Martin TG, Rodriguez C, Nooka A, Banerjee A, Chastain K, Perales-Puchalt A, Stephenson T, Uhlar C, Kobos R, van der Holt B, Kruyswijk S, Kuipers MT, Groen K, Vishwamitra D, Skerget S, Cortes-Selva D, Doyle M, Zaaijer HL, Zweegman S, Verona RI, van de Donk NWCJ
Blood Adv 2024 Jan 9;8(1):194-206. doi: 10.1182/bloodadvances.2023011658. PMID: 38052042Free PMC Article
Emerging Concepts in Immune Thrombocytopenia.
Swinkels M, Rijkers M, Voorberg J, Vidarsson G, Leebeek FWG, Jansen AJG
Front Immunol 2018;9:880. Epub 2018 Apr 30 doi: 10.3389/fimmu.2018.00880. PMID: 29760702Free PMC Article
Enfuvirtide.
Dando TM, Perry CM
Drugs 2003;63(24):2755-66; discussion 2767-8. doi: 10.2165/00003495-200363240-00005. PMID: 14664654
Frozen red cells.
Meryman HT
Transfus Med Rev 1989 Apr;3(2):121-7. doi: 10.1016/s0887-7963(89)70073-0. PMID: 2520548

Diagnosis

Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange.
Kühne L, Knöbl P, Eller K, Thaler J, Sperr WR, Gleixner K, Osterholt T, Kaufeld J, Menne J, Buxhofer-Ausch V, Mühlfeld A, Seelow E, Schreiber A, Todorova P, Cukoski S, Jabs WJ, Özcan F, Gäckler A, Schönfelder K, Seibert FS, Westhoff T, Schwenger V, Eichenauer DA, Völker LA, Brinkkoetter PT
Blood 2024 Oct 3;144(14):1486-1495. doi: 10.1182/blood.2023023780. PMID: 38838300
Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis.
Shen HH, Zhang YY, Wang XY, Wang CJ, Wang Y, Ye JF, Li MQ
Biomolecules 2024 Jan 16;14(1) doi: 10.3390/biom14010116. PMID: 38254716Free PMC Article
Teclistamab impairs humoral immunity in patients with heavily pretreated myeloma: importance of immunoglobulin supplementation.
Frerichs KA, Verkleij CPM, Mateos MV, Martin TG, Rodriguez C, Nooka A, Banerjee A, Chastain K, Perales-Puchalt A, Stephenson T, Uhlar C, Kobos R, van der Holt B, Kruyswijk S, Kuipers MT, Groen K, Vishwamitra D, Skerget S, Cortes-Selva D, Doyle M, Zaaijer HL, Zweegman S, Verona RI, van de Donk NWCJ
Blood Adv 2024 Jan 9;8(1):194-206. doi: 10.1182/bloodadvances.2023011658. PMID: 38052042Free PMC Article
Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury.
Gao L, Zhao Y, Wu H, Lin X, Guo F, Li J, Long Y, Zhou B, She J, Zhang C, Sheng J, Jin L, Wu Y, Huang H
Circulation 2023 Dec 12;148(24):1958-1973. Epub 2023 Nov 8 doi: 10.1161/CIRCULATIONAHA.123.065827. PMID: 37937441Free PMC Article
Advances in the management of TTP.
Subhan M, Scully M
Blood Rev 2022 Sep;55:100945. Epub 2022 Feb 17 doi: 10.1016/j.blre.2022.100945. PMID: 35216839

Therapy

BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trial.
Wang W, He S, Zhang W, Zhang H, DeStefano VM, Wada M, Pinz K, Deener G, Shah D, Hagag N, Wang M, Hong M, Zeng R, Lan T, Ma Y, Li F, Liang Y, Guo Z, Zou C, Wang M, Ding L, Ma Y, Yuan Y
Ann Rheum Dis 2024 Sep 30;83(10):1304-1314. doi: 10.1136/ard-2024-225785. PMID: 38777376
Teclistamab impairs humoral immunity in patients with heavily pretreated myeloma: importance of immunoglobulin supplementation.
Frerichs KA, Verkleij CPM, Mateos MV, Martin TG, Rodriguez C, Nooka A, Banerjee A, Chastain K, Perales-Puchalt A, Stephenson T, Uhlar C, Kobos R, van der Holt B, Kruyswijk S, Kuipers MT, Groen K, Vishwamitra D, Skerget S, Cortes-Selva D, Doyle M, Zaaijer HL, Zweegman S, Verona RI, van de Donk NWCJ
Blood Adv 2024 Jan 9;8(1):194-206. doi: 10.1182/bloodadvances.2023011658. PMID: 38052042Free PMC Article
Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases.
Hamilton JD, Harel S, Swanson BN, Brian W, Chen Z, Rice MS, Amin N, Ardeleanu M, Radin A, Shumel B, Ruddy M, Patel N, Pirozzi G, Mannent L, Graham NMH
Clin Exp Allergy 2021 Jul;51(7):915-931. Epub 2021 Jun 26 doi: 10.1111/cea.13954. PMID: 34037993Free PMC Article
Enfuvirtide.
Dando TM, Perry CM
Drugs 2003;63(24):2755-66; discussion 2767-8. doi: 10.2165/00003495-200363240-00005. PMID: 14664654
Zalcitabine.
Shelton MJ, O'Donnell AM, Morse GD
Ann Pharmacother 1993 Apr;27(4):480-9. doi: 10.1177/106002809302700416. PMID: 8097417

Prognosis

Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis.
Shen HH, Zhang YY, Wang XY, Wang CJ, Wang Y, Ye JF, Li MQ
Biomolecules 2024 Jan 16;14(1) doi: 10.3390/biom14010116. PMID: 38254716Free PMC Article
SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation.
Xu C, Bian Z, Wang X, Niu N, Liu L, Xiao Y, Zhu J, Huang N, Zhang Y, Chen Y, Wu Q, Sun F, Zhu X, Pan Q
J Exp Clin Cancer Res 2023 Dec 5;42(1):331. doi: 10.1186/s13046-023-02906-8. PMID: 38049865Free PMC Article
Salidroside intensifies mitochondrial function of CoCl(2)-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway.
Hou Y, Zhang Y, Jiang S, Xie N, Zhang Y, Meng X, Wang X
Phytomedicine 2023 Jan;109:154568. Epub 2022 Nov 20 doi: 10.1016/j.phymed.2022.154568. PMID: 36610162
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Plasma-depleted versus red cell-reduced umbilical cord blood.
Young W
Cell Transplant 2014;23(4-5):407-15. doi: 10.3727/096368914X678481. PMID: 24816442

Clinical prediction guides

Teclistamab impairs humoral immunity in patients with heavily pretreated myeloma: importance of immunoglobulin supplementation.
Frerichs KA, Verkleij CPM, Mateos MV, Martin TG, Rodriguez C, Nooka A, Banerjee A, Chastain K, Perales-Puchalt A, Stephenson T, Uhlar C, Kobos R, van der Holt B, Kruyswijk S, Kuipers MT, Groen K, Vishwamitra D, Skerget S, Cortes-Selva D, Doyle M, Zaaijer HL, Zweegman S, Verona RI, van de Donk NWCJ
Blood Adv 2024 Jan 9;8(1):194-206. doi: 10.1182/bloodadvances.2023011658. PMID: 38052042Free PMC Article
Salidroside intensifies mitochondrial function of CoCl(2)-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway.
Hou Y, Zhang Y, Jiang S, Xie N, Zhang Y, Meng X, Wang X
Phytomedicine 2023 Jan;109:154568. Epub 2022 Nov 20 doi: 10.1016/j.phymed.2022.154568. PMID: 36610162
Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4(+) T lymphocytes in HIV-infected immune non-responders.
Xiao Q, Yan L, Han J, Yang S, Tang Y, Li Q, Lao X, Chen Z, Xiao J, Zhao H, Yu F, Zhang F
EBioMedicine 2022 Dec;86:104382. Epub 2022 Nov 30 doi: 10.1016/j.ebiom.2022.104382. PMID: 36462403Free PMC Article
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.
Wei Y, Lao XM, Xiao X, Wang XY, Wu ZJ, Zeng QH, Wu CY, Wu RQ, Chen ZX, Zheng L, Li B, Kuang DM
Gastroenterology 2019 May;156(6):1890-1904.e16. Epub 2019 Jan 31 doi: 10.1053/j.gastro.2019.01.250. PMID: 30711627
Zalcitabine.
Shelton MJ, O'Donnell AM, Morse GD
Ann Pharmacother 1993 Apr;27(4):480-9. doi: 10.1177/106002809302700416. PMID: 8097417

Recent systematic reviews

Selenium and immune function: a systematic review and meta-analysis of experimental human studies.
Filippini T, Fairweather-Tait S, Vinceti M
Am J Clin Nutr 2023 Jan;117(1):93-110. Epub 2022 Dec 19 doi: 10.1016/j.ajcnut.2022.11.007. PMID: 36789948
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
The Effect of Rosuvastatin on Plasma/Serum Levels of High-Sensitivity C-Reactive Protein, Interleukin-6, and D-Dimer in People Living with Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis.
Ashuro AA, Fan YG, Fu YS, Di DS, Sam NB, Pan HF, Ye DQ
AIDS Res Hum Retroviruses 2021 Nov;37(11):821-833. Epub 2021 Jun 14 doi: 10.1089/AID.2020.0273. PMID: 33913752
Serological markers for human intestinal ischemia: A systematic review.
Derikx JP, Schellekens DH, Acosta S
Best Pract Res Clin Gastroenterol 2017 Feb;31(1):69-74. Epub 2017 Feb 7 doi: 10.1016/j.bpg.2017.01.004. PMID: 28395790
Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection.
Li L, Tian JH, Yang K, Zhang P, Jia WQ
Cochrane Database Syst Rev 2014 Jul 26;2014(7):CD008439. doi: 10.1002/14651858.CD008439.pub3. PMID: 25063928Free PMC Article

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