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IgM heavy chain paraproteinemia

MedGen UID:
1707667
Concept ID:
C5209278
Finding
HPO: HP:0020196

Definition

An abnormal IgM heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIgM heavy chain paraproteinemia

Professional guidelines

PubMed

Ermak N, Nguyen-Khoa T, Alyanakian MA
Ann Biol Clin (Paris) 2016 Oct 1;74(5):597-605. doi: 10.1684/abc.2016.1180. PMID: 27707674
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article
Babusíková O, Stevulová L
Neoplasma 2004;51(6):422-30. PMID: 15640950

Recent clinical studies

Etiology

Napodano C, Ciasca G, Chiusolo P, Pocino K, Gragnani L, Stefanile A, Gulli F, Lorini S, Minnella G, Fosso F, Di Santo R, Romanò S, Basile V, De Stefano V, Rapaccini GL, Zignego AL, Di Stasio E, Marino M, Basile U
Int J Mol Sci 2023 Jul 18;24(14) doi: 10.3390/ijms241411602. PMID: 37511357Free PMC Article
Ermak N, Nguyen-Khoa T, Alyanakian MA
Ann Biol Clin (Paris) 2016 Oct 1;74(5):597-605. doi: 10.1684/abc.2016.1180. PMID: 27707674
Magnano L, Fernández de Larrea C, Elena M, Cibeira MT, Tovar N, Aróstegui JI, Pedrosa F, Rosiñol L, Filella X, Yagüe J, Bladé J
Clin Lymphoma Myeloma Leuk 2016 Jun;16(6):e71-7. Epub 2016 Feb 27 doi: 10.1016/j.clml.2016.02.034. PMID: 27013181
Johnson SA, Oscier DG, Leblond V
Blood Rev 2002 Sep;16(3):175-84. doi: 10.1016/s0268-960x(02)00016-4. PMID: 12163003
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Diagnosis

Napodano C, Ciasca G, Chiusolo P, Pocino K, Gragnani L, Stefanile A, Gulli F, Lorini S, Minnella G, Fosso F, Di Santo R, Romanò S, Basile V, De Stefano V, Rapaccini GL, Zignego AL, Di Stasio E, Marino M, Basile U
Int J Mol Sci 2023 Jul 18;24(14) doi: 10.3390/ijms241411602. PMID: 37511357Free PMC Article
Li X, Qi X, Ma Z, Huang W
BMC Nephrol 2022 Nov 30;23(1):382. doi: 10.1186/s12882-022-03005-0. PMID: 36451151Free PMC Article
Magnano L, Fernández de Larrea C, Elena M, Cibeira MT, Tovar N, Aróstegui JI, Pedrosa F, Rosiñol L, Filella X, Yagüe J, Bladé J
Clin Lymphoma Myeloma Leuk 2016 Jun;16(6):e71-7. Epub 2016 Feb 27 doi: 10.1016/j.clml.2016.02.034. PMID: 27013181
Johnson SA, Oscier DG, Leblond V
Blood Rev 2002 Sep;16(3):175-84. doi: 10.1016/s0268-960x(02)00016-4. PMID: 12163003
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Therapy

Li X, Qi X, Ma Z, Huang W
BMC Nephrol 2022 Nov 30;23(1):382. doi: 10.1186/s12882-022-03005-0. PMID: 36451151Free PMC Article
Basile U, Gulli F, Napodano C, Pocino K, Basile V, Marrapodi R, Colantuono S, Todi L, Marino M, Rapaccini GL, Visentini M
Biotechnol Appl Biochem 2021 Apr;68(2):319-329. Epub 2020 May 17 doi: 10.1002/bab.1929. PMID: 32333692
Wechalekar AD, Chakraborty R, Lentzsch S
Hematol Oncol Clin North Am 2020 Dec;34(6):1027-1039. Epub 2020 Oct 1 doi: 10.1016/j.hoc.2020.08.016. PMID: 33099421
Tete SM, Kipling D, Westra J, de Haan A, Bijl M, Dunn-Walters DK, Sahota SS, Bos NA
Exp Hematol 2015 Jun;43(6):439-47.e1. Epub 2015 Mar 18 doi: 10.1016/j.exphem.2015.02.005. PMID: 25795522
Johnson SA, Oscier DG, Leblond V
Blood Rev 2002 Sep;16(3):175-84. doi: 10.1016/s0268-960x(02)00016-4. PMID: 12163003

Prognosis

Ermak N, Nguyen-Khoa T, Alyanakian MA
Ann Biol Clin (Paris) 2016 Oct 1;74(5):597-605. doi: 10.1684/abc.2016.1180. PMID: 27707674
Magnano L, Fernández de Larrea C, Elena M, Cibeira MT, Tovar N, Aróstegui JI, Pedrosa F, Rosiñol L, Filella X, Yagüe J, Bladé J
Clin Lymphoma Myeloma Leuk 2016 Jun;16(6):e71-7. Epub 2016 Feb 27 doi: 10.1016/j.clml.2016.02.034. PMID: 27013181
Eckold J, Poenisch W, Drogies T, Kratzsch J, Teupser D, Thiery J, Bruegel M
Clin Lab 2014;60(9):1491-500. doi: 10.7754/clin.lab.2013.131010. PMID: 25291945
Yahata M, Nakaya I, Takahashi S, Sakuma T, Sato H, Soma J
Clin Nephrol 2012 Mar;77(3):254-60. doi: 10.5414/cn107230. PMID: 22377259
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Clinical prediction guides

Cho H, Jung J, Chae H, Joong Lee J, Kim M, Oh EJ, Kim Y, Min CK
Clin Biochem 2022 Sep;107:7-12. Epub 2022 Jun 1 doi: 10.1016/j.clinbiochem.2022.05.011. PMID: 35660484
Magnano L, Fernández de Larrea C, Elena M, Cibeira MT, Tovar N, Aróstegui JI, Pedrosa F, Rosiñol L, Filella X, Yagüe J, Bladé J
Clin Lymphoma Myeloma Leuk 2016 Jun;16(6):e71-7. Epub 2016 Feb 27 doi: 10.1016/j.clml.2016.02.034. PMID: 27013181
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article
Visentini M, Conti V, Cristofoletti C, Lazzeri C, Marrapodi R, Russo G, Casato M, Fiorilli M
Autoimmun Rev 2013 Jan;12(3):430-5. Epub 2012 Aug 23 doi: 10.1016/j.autrev.2012.08.016. PMID: 22940579
Yahata M, Nakaya I, Takahashi S, Sakuma T, Sato H, Soma J
Clin Nephrol 2012 Mar;77(3):254-60. doi: 10.5414/cn107230. PMID: 22377259

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