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Abnormal Blood Chemistry and Hematology Test Result

MedGen UID:
233128
•Concept ID:
C1332129
•
Finding

Definition

A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal Blood Chemistry and Hematology Test Result

Professional guidelines

PubMed

Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis.
Castaman G, Hillarp A, Goodeve A
Haemophilia 2014 May;20 Suppl 4(0 4):65-70. doi: 10.1111/hae.12410. PMID: 24762278Free PMC Article
Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management.
Pardanani A
Am J Hematol 2012 Apr;87(4):401-11. doi: 10.1002/ajh.23134. PMID: 22410759
Platelet function and interferon alpha-2a treatment in essential thrombocythaemia.
Catani L, Gugliotta L, Cascione ML, Mattioli Belmonte M, Vianelli N, Belardinelli AR, Tura S
Eur J Haematol 1991 Mar;46(3):158-62. doi: 10.1111/j.1600-0609.1991.tb01270.x. PMID: 1826272

Recent clinical studies

Etiology

Evaluation of role of HPLC (Merits & Pitfalls), in the diagnosis of various hemoglobinopathies & thalassemic syndromes.
Baig MA, Swamy KB, Baksh AD, Bahashwan A, Moshrif Y, Al Sawat A, Al Mutairi N, Alharbi N
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):518-523. doi: 10.4103/IJPM.IJPM_709_20. PMID: 34341263
Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing.
Kurstjens S, van der Horst A, Herpers R, Geerits MWL, Kluiters-de Hingh YCM, Göttgens EL, Blaauw MJT, Thelen MHM, Elisen MGLM, Kusters R
Clin Chem Lab Med 2020 Aug 27;58(9):1587-1593. Epub 2020 Jun 29 doi: 10.1515/cclm-2020-0593. PMID: 32598302
CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy.
Iwatani H, Nagasawa Y, Yamamoto R, Iio K, Mizui M, Horii A, Kitahara T, Inohara H, Kumanogoh A, Imai E, Rakugi H, Isaka Y
Clin Exp Nephrol 2015 Apr;19(2):216-24. Epub 2014 May 6 doi: 10.1007/s10157-014-0968-z. PMID: 24798970
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Diagnosis

Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.
Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G
Clin Biochem 2020 Jul;81:1-8. Epub 2020 May 27 doi: 10.1016/j.clinbiochem.2020.05.012. PMID: 32473151Free PMC Article
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874
Normocytic and macrocytic anemias.
Brown RG
Postgrad Med 1991 Jun;89(8):125-32, 135-6. doi: 10.1080/00325481.1991.11700957. PMID: 1903885

Therapy

A score-based method of immune status evaluation for healthy individuals with complete blood cell counts.
Zhang M, Zhao C, Cheng Q, Xu J, Xu N, Yu L, Feng W
BMC Bioinformatics 2023 Dec 11;24(1):467. doi: 10.1186/s12859-023-05603-7. PMID: 38082403Free PMC Article
Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage.
Roberts I, Shakur H, Fawole B, Kuti M, Olayemi O, Bello A, Ogunbode O, Kotila T, Aimakhu CO, Olutogun T, Hunt BJ, Huque S
BMC Pregnancy Childbirth 2018 May 9;18(1):143. doi: 10.1186/s12884-018-1794-1. PMID: 29743045Free PMC Article
CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy.
Iwatani H, Nagasawa Y, Yamamoto R, Iio K, Mizui M, Horii A, Kitahara T, Inohara H, Kumanogoh A, Imai E, Rakugi H, Isaka Y
Clin Exp Nephrol 2015 Apr;19(2):216-24. Epub 2014 May 6 doi: 10.1007/s10157-014-0968-z. PMID: 24798970
Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura.
Liu B, Zhao H, Poon MC, Han Z, Gu D, Xu M, Jia H, Yang R, Han ZC
Eur J Haematol 2007 Feb;78(2):139-43. doi: 10.1111/j.1600-0609.2006.00780.x. PMID: 17328716
A cross-sectional study of ethylene glycol monomethyl ether process employees.
Cook RR, Bodner KM, Kolesar RC, Uhlmann CS, VanPeenen PF, Dickson GS, Flanagan K
Arch Environ Health 1982 Nov-Dec;37(6):346-51. doi: 10.1080/00039896.1982.10667589. PMID: 6983865

Prognosis

Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing.
Kurstjens S, van der Horst A, Herpers R, Geerits MWL, Kluiters-de Hingh YCM, Göttgens EL, Blaauw MJT, Thelen MHM, Elisen MGLM, Kusters R
Clin Chem Lab Med 2020 Aug 27;58(9):1587-1593. Epub 2020 Jun 29 doi: 10.1515/cclm-2020-0593. PMID: 32598302
Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.
Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G
Clin Biochem 2020 Jul;81:1-8. Epub 2020 May 27 doi: 10.1016/j.clinbiochem.2020.05.012. PMID: 32473151Free PMC Article
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.
Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G
Clin Chem Lab Med 2020 Jun 25;58(7):1021-1028. doi: 10.1515/cclm-2020-0369. PMID: 32286245
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Clinical prediction guides

Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing.
Kurstjens S, van der Horst A, Herpers R, Geerits MWL, Kluiters-de Hingh YCM, Göttgens EL, Blaauw MJT, Thelen MHM, Elisen MGLM, Kusters R
Clin Chem Lab Med 2020 Aug 27;58(9):1587-1593. Epub 2020 Jun 29 doi: 10.1515/cclm-2020-0593. PMID: 32598302
Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.
Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G
Clin Biochem 2020 Jul;81:1-8. Epub 2020 May 27 doi: 10.1016/j.clinbiochem.2020.05.012. PMID: 32473151Free PMC Article
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.
Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G
Clin Chem Lab Med 2020 Jun 25;58(7):1021-1028. doi: 10.1515/cclm-2020-0369. PMID: 32286245
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Recent systematic reviews

Routine preoperative testing: a systematic review of the evidence.
Munro J, Booth A, Nicholl J
Health Technol Assess 1997;1(12):i-iv; 1-62. PMID: 9483155

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