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Advanced Pancreatic Neuroendocrine Neoplasm

MedGen UID:
1712751
Concept ID:
C5237189
Neoplastic Process

Definition

A pancreatic neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Pancreatic Neuroendocrine Neoplasm

Professional guidelines

PubMed

Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Pavel M, Öberg K, Falconi M, Krenning EP, Sundin A, Perren A, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Jul;31(7):844-860. Epub 2020 Apr 6 doi: 10.1016/j.annonc.2020.03.304. PMID: 32272208
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Recent clinical studies

Etiology

Kawasaki K, Rekhtman N, Quintanal-Villalonga Á, Rudin CM
Nat Rev Clin Oncol 2023 Jan;20(1):16-32. Epub 2022 Oct 28 doi: 10.1038/s41571-022-00696-0. PMID: 36307533
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC
JAMA Oncol 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589. PMID: 28448665Free PMC Article
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG, Tomassetti P, Pavel ME, Hoosen S, Haas T, Lincy J, Lebwohl D, Öberg K; RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
N Engl J Med 2011 Feb 10;364(6):514-23. doi: 10.1056/NEJMoa1009290. PMID: 21306238Free PMC Article

Diagnosis

Hofland J, Falconi M, Christ E, Castaño JP, Faggiano A, Lamarca A, Perren A, Petrucci S, Prasad V, Ruszniewski P, Thirlwell C, Vullierme MP, Welin S, Bartsch DK
J Neuroendocrinol 2023 Aug;35(8):e13318. Epub 2023 Aug 14 doi: 10.1111/jne.13318. PMID: 37578384
Fernandes CJ, Leung G, Eads JR, Katona BW
Gastroenterol Clin North Am 2022 Sep;51(3):625-647. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.002. PMID: 36153114
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC
JAMA Oncol 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589. PMID: 28448665Free PMC Article

Therapy

Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG, Tomassetti P, Pavel ME, Hoosen S, Haas T, Lincy J, Lebwohl D, Öberg K; RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
N Engl J Med 2011 Feb 10;364(6):514-23. doi: 10.1056/NEJMoa1009290. PMID: 21306238Free PMC Article

Prognosis

Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article
Jensen RT, Bodei L, Capdevila J, Couvelard A, Falconi M, Glasberg S, Kloppel G, Lamberts S, Peeters M, Rindi G, Rinke A, Rothmund M, Sundin A, Welin S, Fazio N; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants
Neuroendocrinology 2019;108(1):26-36. Epub 2018 Oct 3 doi: 10.1159/000494258. PMID: 30282083
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC
JAMA Oncol 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589. PMID: 28448665Free PMC Article

Clinical prediction guides

Kunz PL, Graham NT, Catalano PJ, Nimeiri HS, Fisher GA, Longacre TA, Suarez CJ, Martin BA, Yao JC, Kulke MH, Hendifar AE, Shanks JC, Shah MH, Zalupski MM, Schmulbach EL, Reidy-Lagunes DL, Strosberg JR, O'Dwyer PJ, Benson AB 3rd
J Clin Oncol 2023 Mar 1;41(7):1359-1369. Epub 2022 Oct 19 doi: 10.1200/JCO.22.01013. PMID: 36260828Free PMC Article
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article
Lee L, Ito T, Jensen RT
Expert Rev Anticancer Ther 2019 Dec;19(12):1029-1050. Epub 2019 Nov 27 doi: 10.1080/14737140.2019.1693893. PMID: 31738624Free PMC Article
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, Chen JS, Hörsch D, Hammel P, Wiedenmann B, Van Cutsem E, Patyna S, Lu DR, Blanckmeister C, Chao R, Ruszniewski P
N Engl J Med 2011 Feb 10;364(6):501-13. doi: 10.1056/NEJMoa1003825. PMID: 21306237

Recent systematic reviews

Cigrovski Berkovic M, Coppola A, Sesa V, Mrzljak A, Lai Q
World J Gastroenterol 2024 Feb 21;30(7):759-769. doi: 10.3748/wjg.v30.i7.759. PMID: 38515954Free PMC Article
Satapathy S, Mittal BR
Nucl Med Commun 2019 Dec;40(12):1195-1203. doi: 10.1097/MNM.0000000000001103. PMID: 31658219
Hurtado-Pardo L, Cienfuegos JA, Ruiz-Canela M, Panadero P, Benito A, Hernández Lizoain JL
Rev Esp Enferm Dig 2017 Nov;109(11):778-787. doi: 10.17235/reed.2017.5044/2017. PMID: 29072081
Cannistrà M, Ruggiero M, Zullo A, Serafini S, Grande R, Nardo B
Int J Surg 2015 Sep;21 Suppl 1:S15-21. Epub 2015 Jun 26 doi: 10.1016/j.ijsu.2015.04.093. PMID: 26123383
Valle JW, Eatock M, Clueit B, Gabriel Z, Ferdinand R, Mitchell S
Cancer Treat Rev 2014 Apr;40(3):376-89. Epub 2013 Sep 8 doi: 10.1016/j.ctrv.2013.08.007. PMID: 24296109

Supplemental Content

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