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Locally Advanced Ewing Sarcoma

MedGen UID:
1717811
•Concept ID:
C5235953
•
Neoplastic Process

Definition

Ewing sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Ewing Sarcoma

Professional guidelines

PubMed

Radiotherapy in bone sarcoma: the quest for better treatment option.
Locquet MA, Brahmi M, Blay JY, Dutour A
BMC Cancer 2023 Aug 11;23(1):742. doi: 10.1186/s12885-023-11232-3. PMID: 37563551Free PMC Article
Current topics and management of head and neck sarcomas.
Kobayashi K, Hanai N, Yoshimoto S, Saito Y, Homma A
Jpn J Clin Oncol 2023 Aug 30;53(9):743-756. doi: 10.1093/jjco/hyad048. PMID: 37309253Free PMC Article
Management of sarcomas in children, adolescents and adults: Interactions in two different age groups under the umbrellas of GSF-GETO and SFCE, with the support of the NETSARC+ network.
Bompas E, Martin V, Meniai F, Toulmonde M, Marec-Berard P, Claude L, Ducimetiere F, Chargari C, Minard-Colin V, Corradini N, Laurence V, Piperno-Neumann S, Defachelles AS, Bernier V, Italiano A, Orbach D, Blay JY, Gaspar N, Berlanga P
Bull Cancer 2021 Feb;108(2):163-176. Epub 2021 Jan 14 doi: 10.1016/j.bulcan.2020.10.009. PMID: 33455736

Recent clinical studies

Etiology

Systemic treatments and outcomes in CIC-rearranged Sarcoma: A national multi-centre clinicopathological series and literature review.
Connolly EA, Bhadri VA, Wake J, Ingley KM, Lewin J, Bae S, Wong DD, Long AP, Pryor D, Thompson SR, Strach MC, Grimison PS, Mahar A, Bonar F, Maclean F, Hong A
Cancer Med 2022 Apr;11(8):1805-1816. Epub 2022 Feb 17 doi: 10.1002/cam4.4580. PMID: 35178869Free PMC Article
Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors?
Mangoni M, Sottili M, Salvatore G, Campanacci D, Scoccianti G, Beltrami G, Delli Paoli C, Dominici L, Maragna V, Olmetto E, Meattini I, Desideri I, Bonomo P, Greto D, Livi L
Radiol Med 2019 Apr;124(4):282-289. Epub 2018 Mar 26 doi: 10.1007/s11547-018-0877-4. PMID: 29582320
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Ewing and osteogenic sarcoma: evidence for multidisciplinary management.
Sciubba DM, Okuno SH, Dekutoski MB, Gokaslan ZL
Spine (Phila Pa 1976) 2009 Oct 15;34(22 Suppl):S58-68. doi: 10.1097/BRS.0b013e3181ba6436. PMID: 19829278
Treatment of Ewing sarcoma family of tumors: current status and outlook for the future.
Rodriguez-Galindo C, Spunt SL, Pappo AS
Med Pediatr Oncol 2003 May;40(5):276-87. doi: 10.1002/mpo.10240. PMID: 12652615

Diagnosis

Recognizing and treating patients with Ewing sarcoma.
Windheuser A, Gardner N
JAAPA 2023 Sep 1;36(9):1-4. doi: 10.1097/01.JAA.0000937324.58262.55. PMID: 37668491
Current topics and management of head and neck sarcomas.
Kobayashi K, Hanai N, Yoshimoto S, Saito Y, Homma A
Jpn J Clin Oncol 2023 Aug 30;53(9):743-756. doi: 10.1093/jjco/hyad048. PMID: 37309253Free PMC Article
Systemic treatments and outcomes in CIC-rearranged Sarcoma: A national multi-centre clinicopathological series and literature review.
Connolly EA, Bhadri VA, Wake J, Ingley KM, Lewin J, Bae S, Wong DD, Long AP, Pryor D, Thompson SR, Strach MC, Grimison PS, Mahar A, Bonar F, Maclean F, Hong A
Cancer Med 2022 Apr;11(8):1805-1816. Epub 2022 Feb 17 doi: 10.1002/cam4.4580. PMID: 35178869Free PMC Article
The adolescent and young adult with cancer: state of the art -- bone tumors.
Rainusso N, Wang LL, Yustein JT
Curr Oncol Rep 2013 Aug;15(4):296-307. doi: 10.1007/s11912-013-0321-9. PMID: 23690089
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Therapy

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Pilot Study of Recurrent Ewing's Sarcoma Management with Vigil/Temozolomide/Irinotecan and Assessment of Circulating Tumor (ct) DNA.
Anderson P, Ghisoli M, Crompton BD, Klega KS, Wexler LH, Slotkin EK, Stanbery L, Manning L, Wallraven G, Manley M, Horvath S, Bognar E, Nemunaitis J
Clin Cancer Res 2023 May 1;29(9):1689-1697. doi: 10.1158/1078-0432.CCR-22-2292. PMID: 36780200Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Proton therapy for sarcomas.
Keole S, Ashman JB, Daniels TB
Cancer J 2014 Nov-Dec;20(6):409-14. doi: 10.1097/PPO.0000000000000084. PMID: 25415687
Treatment of Ewing sarcoma family of tumors: current status and outlook for the future.
Rodriguez-Galindo C, Spunt SL, Pappo AS
Med Pediatr Oncol 2003 May;40(5):276-87. doi: 10.1002/mpo.10240. PMID: 12652615

Prognosis

Recognizing and treating patients with Ewing sarcoma.
Windheuser A, Gardner N
JAAPA 2023 Sep 1;36(9):1-4. doi: 10.1097/01.JAA.0000937324.58262.55. PMID: 37668491
Systemic treatments and outcomes in CIC-rearranged Sarcoma: A national multi-centre clinicopathological series and literature review.
Connolly EA, Bhadri VA, Wake J, Ingley KM, Lewin J, Bae S, Wong DD, Long AP, Pryor D, Thompson SR, Strach MC, Grimison PS, Mahar A, Bonar F, Maclean F, Hong A
Cancer Med 2022 Apr;11(8):1805-1816. Epub 2022 Feb 17 doi: 10.1002/cam4.4580. PMID: 35178869Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Treatment of advanced Ewing tumors by combined radiochemotherapy and engineered cellular transplants.
Burdach S
Pediatr Transplant 2004 Jun;8 Suppl 5:67-82. doi: 10.1111/j.1398-2265.2004.00186.x. PMID: 15125708
Treatment of Ewing sarcoma family of tumors: current status and outlook for the future.
Rodriguez-Galindo C, Spunt SL, Pappo AS
Med Pediatr Oncol 2003 May;40(5):276-87. doi: 10.1002/mpo.10240. PMID: 12652615

Clinical prediction guides

Use of pedicled flaps after oncologic resections in pediatric patients.
Blanco MD, de la Torre M, Lorca C, Del Cañizo A, Bada I, Monje S, García-Casillas MA, Villa Á, de Tomás E, Berenguer B
Pediatr Surg Int 2024 Mar 3;40(1):64. doi: 10.1007/s00383-024-05654-8. PMID: 38433161
Pilot Study of Recurrent Ewing's Sarcoma Management with Vigil/Temozolomide/Irinotecan and Assessment of Circulating Tumor (ct) DNA.
Anderson P, Ghisoli M, Crompton BD, Klega KS, Wexler LH, Slotkin EK, Stanbery L, Manning L, Wallraven G, Manley M, Horvath S, Bognar E, Nemunaitis J
Clin Cancer Res 2023 May 1;29(9):1689-1697. doi: 10.1158/1078-0432.CCR-22-2292. PMID: 36780200Free PMC Article
Primary round cell sarcomas of the urinary bladder with EWSR1 rearrangement: a multi-institutional study of thirteen cases with a review of the literature.
Baisakh MR, Tiwari A, Gandhi JS, Naik S, Sharma SK, Balzer BL, Sharma S, Peddinti K, Jha S, Sahu PK, Pradhan D, Geller M, Amin MB, Dhillon J, Mohanty SK
Hum Pathol 2020 Oct;104:84-95. Epub 2020 Aug 14 doi: 10.1016/j.humpath.2020.08.001. PMID: 32798549
Renal Ewing tumors.
Zöllner S, Dirksen U, Jürgens H, Ranft A
Ann Oncol 2013 Sep;24(9):2455-61. Epub 2013 Jun 11 doi: 10.1093/annonc/mdt215. PMID: 23761687
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Recent systematic reviews

Primary Ewing sarcoma of the lung: A systematic review of the recent literature.
Fedeli MA, Marras V, Fara AM, Deiana A, Lobrano R, Cossu A, Paliogiannis P
Ann Diagn Pathol 2023 Aug;65:152152. Epub 2023 Apr 29 doi: 10.1016/j.anndiagpath.2023.152152. PMID: 37149954
Ewing and osteogenic sarcoma: evidence for multidisciplinary management.
Sciubba DM, Okuno SH, Dekutoski MB, Gokaslan ZL
Spine (Phila Pa 1976) 2009 Oct 15;34(22 Suppl):S58-68. doi: 10.1097/BRS.0b013e3181ba6436. PMID: 19829278

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