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Renal neutrophilic tubulitis

MedGen UID:
1718305
•Concept ID:
C5397614
•
Disease or Syndrome
HPO: HP:0032590

Definition

Infiltration of the renal tubular epithelium by neutrophils. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal neutrophilic tubulitis

Recent clinical studies

Etiology

Implication of platelets and complement C3 as link between innate immunity and tubulointerstitial injury in renal vasculitis with MPO-ANCA seropositivity.
Baier E, Tampe D, Kluge IA, Hakroush S, Tampe B
Front Immunol 2022;13:1054457. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1054457. PMID: 36439156Free PMC Article
Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis.
Hakroush S, Tampe D, Ströbel P, Korsten P, Tampe B
Front Immunol 2021;12:737708. Epub 2021 Oct 21 doi: 10.3389/fimmu.2021.737708. PMID: 34759920Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037
Tubular lesions predict renal outcome in antineutrophil cytoplasmic antibody-associated glomerulonephritis after rituximab therapy.
Berden AE, Jones RB, Erasmus DD, Walsh M, Noël LH, Ferrario F, Waldherr R, Bruijn JA, Jayne DR, Bajema IM; European Vasculitis Society
J Am Soc Nephrol 2012 Feb;23(2):313-21. Epub 2011 Nov 17 doi: 10.1681/ASN.2011040330. PMID: 22095945
Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology.
Schaub S, Mayr M, Hönger G, Bestland J, Steiger J, Regeniter A, Mihatsch MJ, Wilkins JA, Rush D, Nickerson P
Transplantation 2007 Jul 15;84(1):104-12. doi: 10.1097/01.tp.0000268808.39401.e8. PMID: 17627245

Diagnosis

Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review.
He X, Wen Y, Hu R, Wu H, Ye W, Yue C, Qin Y, Xia P, Chen L
Clin Rheumatol 2022 Nov;41(11):3551-3563. Epub 2022 Jun 27 doi: 10.1007/s10067-022-06264-2. PMID: 35759125Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037
Diffuse tubulointerstitial nephritis associated with ANCA-negative pauci-immune glomerulonephritis.
Kanzaki G, Tsuboi N, Yokoo T, Miyazaki Y, Utsunomiya Y, Hosoya T
Clin Exp Nephrol 2012 Jun;16(3):480-4. Epub 2012 Jan 24 doi: 10.1007/s10157-012-0587-5. PMID: 22270187
Neutrophilic tubulitis as a marker for urinary tract infection in renal allograft biopsies with C4d deposition.
Gupta G, Shapiro R, Girnita A, Batal I, McCauley J, Basu A, Tan H, Randhawa P
Transplantation 2009 Apr 15;87(7):1013-8. doi: 10.1097/TP.0b013e31819ca304. PMID: 19352120
Occurrence of urinary tract infection in patients with renal allograft biopsies showing neutrophilic tubulitis.
Fonseca LE Jr, Shapiro R, Randhawa PS
Mod Pathol 2003 Apr;16(4):281-5. doi: 10.1097/01.MP.0000062658.47481.69. PMID: 12692191

Therapy

Importance of Follow-Up Biopsies in the Prediction of Renal Allograft Survival Following Polyomavirus-Associated Nephropathy.
Özdemir BH, Ok Atılgan A, Akyüz Özdemir A, Akçay E, Haberal M
Exp Clin Transplant 2023 Jul;21(7):568-577. doi: 10.6002/ect.2023.0080. PMID: 37584537
Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review.
He X, Wen Y, Hu R, Wu H, Ye W, Yue C, Qin Y, Xia P, Chen L
Clin Rheumatol 2022 Nov;41(11):3551-3563. Epub 2022 Jun 27 doi: 10.1007/s10067-022-06264-2. PMID: 35759125Free PMC Article
Tubular lesions predict renal outcome in antineutrophil cytoplasmic antibody-associated glomerulonephritis after rituximab therapy.
Berden AE, Jones RB, Erasmus DD, Walsh M, Noël LH, Ferrario F, Waldherr R, Bruijn JA, Jayne DR, Bajema IM; European Vasculitis Society
J Am Soc Nephrol 2012 Feb;23(2):313-21. Epub 2011 Nov 17 doi: 10.1681/ASN.2011040330. PMID: 22095945
Neutrophilic tubulitis as a marker for urinary tract infection in renal allograft biopsies with C4d deposition.
Gupta G, Shapiro R, Girnita A, Batal I, McCauley J, Basu A, Tan H, Randhawa P
Transplantation 2009 Apr 15;87(7):1013-8. doi: 10.1097/TP.0b013e31819ca304. PMID: 19352120

Prognosis

Importance of Follow-Up Biopsies in the Prediction of Renal Allograft Survival Following Polyomavirus-Associated Nephropathy.
Özdemir BH, Ok Atılgan A, Akyüz Özdemir A, Akçay E, Haberal M
Exp Clin Transplant 2023 Jul;21(7):568-577. doi: 10.6002/ect.2023.0080. PMID: 37584537
Implication of platelets and complement C3 as link between innate immunity and tubulointerstitial injury in renal vasculitis with MPO-ANCA seropositivity.
Baier E, Tampe D, Kluge IA, Hakroush S, Tampe B
Front Immunol 2022;13:1054457. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1054457. PMID: 36439156Free PMC Article
Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis.
Hakroush S, Tampe D, Ströbel P, Korsten P, Tampe B
Front Immunol 2021;12:737708. Epub 2021 Oct 21 doi: 10.3389/fimmu.2021.737708. PMID: 34759920Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037
Tubular lesions predict renal outcome in antineutrophil cytoplasmic antibody-associated glomerulonephritis after rituximab therapy.
Berden AE, Jones RB, Erasmus DD, Walsh M, Noël LH, Ferrario F, Waldherr R, Bruijn JA, Jayne DR, Bajema IM; European Vasculitis Society
J Am Soc Nephrol 2012 Feb;23(2):313-21. Epub 2011 Nov 17 doi: 10.1681/ASN.2011040330. PMID: 22095945

Clinical prediction guides

Importance of Follow-Up Biopsies in the Prediction of Renal Allograft Survival Following Polyomavirus-Associated Nephropathy.
Özdemir BH, Ok Atılgan A, Akyüz Özdemir A, Akçay E, Haberal M
Exp Clin Transplant 2023 Jul;21(7):568-577. doi: 10.6002/ect.2023.0080. PMID: 37584537
Implication of platelets and complement C3 as link between innate immunity and tubulointerstitial injury in renal vasculitis with MPO-ANCA seropositivity.
Baier E, Tampe D, Kluge IA, Hakroush S, Tampe B
Front Immunol 2022;13:1054457. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1054457. PMID: 36439156Free PMC Article
Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis.
Hakroush S, Tampe D, Ströbel P, Korsten P, Tampe B
Front Immunol 2021;12:737708. Epub 2021 Oct 21 doi: 10.3389/fimmu.2021.737708. PMID: 34759920Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037
Tubular lesions predict renal outcome in antineutrophil cytoplasmic antibody-associated glomerulonephritis after rituximab therapy.
Berden AE, Jones RB, Erasmus DD, Walsh M, Noël LH, Ferrario F, Waldherr R, Bruijn JA, Jayne DR, Bajema IM; European Vasculitis Society
J Am Soc Nephrol 2012 Feb;23(2):313-21. Epub 2011 Nov 17 doi: 10.1681/ASN.2011040330. PMID: 22095945

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