U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal nephron morphology

MedGen UID:
868444
Concept ID:
C4022838
Anatomical Abnormality
Synonym: Abnormality of the nephron
 
HPO: HP:0012575

Definition

A structural anomaly of the nephron. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal nephron morphology

Professional guidelines

PubMed

Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nat Genet 2017 Oct;49(10):1529-1538. Epub 2017 Aug 14 doi: 10.1038/ng.3933. PMID: 28805828Free PMC Article
Parfitt AM, Frame B
Semin Drug Treat 1972 Summer;2(1):83-115. PMID: 4558760

Recent clinical studies

Etiology

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
Nozu K, Nakanishi K, Abe Y, Udagawa T, Okada S, Okamoto T, Kaito H, Kanemoto K, Kobayashi A, Tanaka E, Tanaka K, Hama T, Fujimaru R, Miwa S, Yamamura T, Yamamura N, Horinouchi T, Minamikawa S, Nagata M, Iijima K
Clin Exp Nephrol 2019 Feb;23(2):158-168. Epub 2018 Aug 20 doi: 10.1007/s10157-018-1629-4. PMID: 30128941Free PMC Article
Romagnani P, Remuzzi G, Glassock R, Levin A, Jager KJ, Tonelli M, Massy Z, Wanner C, Anders HJ
Nat Rev Dis Primers 2017 Nov 23;3:17088. doi: 10.1038/nrdp.2017.88. PMID: 29168475
Tsuboi N, Utsunomiya Y, Hosoya T
Nephrol Dial Transplant 2013 Nov;28 Suppl 4:iv108-13. Epub 2013 Jul 17 doi: 10.1093/ndt/gft258. PMID: 23868145
Kandasamy Y, Smith R, Wright IM
Am J Perinatol 2012 Feb;29(2):115-20. Epub 2011 Nov 17 doi: 10.1055/s-0031-1295651. PMID: 22094915

Diagnosis

Romagnani P, Remuzzi G, Glassock R, Levin A, Jager KJ, Tonelli M, Massy Z, Wanner C, Anders HJ
Nat Rev Dis Primers 2017 Nov 23;3:17088. doi: 10.1038/nrdp.2017.88. PMID: 29168475
Gubler MC
Pediatr Nephrol 2014 Jan;29(1):51-9. Epub 2013 May 1 doi: 10.1007/s00467-013-2480-1. PMID: 23636579
Kambham N
Adv Anat Pathol 2012 Sep;19(5):338-47. doi: 10.1097/PAP.0b013e31826663d9. PMID: 22885383
Vehaskari VM
Adv Chronic Kidney Dis 2011 Sep;18(5):317-23. doi: 10.1053/j.ackd.2011.07.001. PMID: 21896372
Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG
N Engl J Med 2003 Jun 19;348(25):2543-56. doi: 10.1056/NEJMra022296. PMID: 12815141

Therapy

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
Ruiz-Hurtado G, Ruilope LM
Hipertens Riesgo Vasc 2018 Jan-Mar;35(1):24-29. Epub 2017 Apr 18 doi: 10.1016/j.hipert.2017.03.002. PMID: 28431922
Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657Free PMC Article
Gonzalez-Aguirre AJ, Durack JC
Tech Vasc Interv Radiol 2016 Sep;19(3):194-202. Epub 2016 Jun 3 doi: 10.1053/j.tvir.2016.06.004. PMID: 27641453
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706

Prognosis

Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P
Nat Rev Dis Primers 2020 Aug 13;6(1):68. doi: 10.1038/s41572-020-0196-7. PMID: 32792490Free PMC Article
Nozu K, Nakanishi K, Abe Y, Udagawa T, Okada S, Okamoto T, Kaito H, Kanemoto K, Kobayashi A, Tanaka E, Tanaka K, Hama T, Fujimaru R, Miwa S, Yamamura T, Yamamura N, Horinouchi T, Minamikawa S, Nagata M, Iijima K
Clin Exp Nephrol 2019 Feb;23(2):158-168. Epub 2018 Aug 20 doi: 10.1007/s10157-018-1629-4. PMID: 30128941Free PMC Article
Witzgall R
Pflugers Arch 2017 Aug;469(7-8):927-936. Epub 2017 Jul 5 doi: 10.1007/s00424-017-2013-z. PMID: 28681095
Vehaskari VM
Adv Chronic Kidney Dis 2011 Sep;18(5):317-23. doi: 10.1053/j.ackd.2011.07.001. PMID: 21896372
Torres VE, Harris PC, Pirson Y
Lancet 2007 Apr 14;369(9569):1287-1301. doi: 10.1016/S0140-6736(07)60601-1. PMID: 17434405

Clinical prediction guides

Clair G, Soloyan H, Cravedi P, Angeletti A, Salem F, Al-Rabadi L, De Filippo RE, Da Sacco S, Lemley KV, Sedrakyan S, Perin L
JCI Insight 2024 Mar 22;9(6) doi: 10.1172/jci.insight.165515. PMID: 38516889Free PMC Article
Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657Free PMC Article
Gonzalez-Aguirre AJ, Durack JC
Tech Vasc Interv Radiol 2016 Sep;19(3):194-202. Epub 2016 Jun 3 doi: 10.1053/j.tvir.2016.06.004. PMID: 27641453
Sahali D, Sendeyo K, Mangier M, Audard V, Zhang SY, Lang P, Ollero M, Pawlak A
Semin Immunopathol 2014 Jul;36(4):421-9. Epub 2014 Jan 9 doi: 10.1007/s00281-013-0415-3. PMID: 24402710Free PMC Article
Gubler MC
Pediatr Nephrol 2014 Jan;29(1):51-9. Epub 2013 May 1 doi: 10.1007/s00467-013-2480-1. PMID: 23636579

Recent systematic reviews

Crisafulli A, Bassareo PP, Kelleher S, Calcaterra G, Mercuro G
Curr Hypertens Rev 2020;16(2):82-90. doi: 10.2174/1573402115666190627140523. PMID: 31244440Free PMC Article
Simeoni M, Armeni A, Summaria C, Cerantonio A, Fuiano G
Ren Fail 2017 Nov;39(1):660-670. doi: 10.1080/0886022X.2017.1361840. PMID: 28805480Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...