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Advanced Endometrioid Adenocarcinoma

MedGen UID:
1753443
•Concept ID:
C5421304
•
Neoplastic Process

Definition

Endometrioid adenocarcinoma that has spread extensively from the original site of growth to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Endometrioid Adenocarcinoma

Professional guidelines

PubMed

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Selecting Adjuvant Treatment for Endometrial Carcinoma Using Molecular Risk Factors.
Wortman BG, Nout RA, Bosse T, Creutzberg CL
Curr Oncol Rep 2019 Jul 31;21(9):83. doi: 10.1007/s11912-019-0825-z. PMID: 31367798Free PMC Article
Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446

Recent clinical studies

Therapy

Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis.
Shen Y, Tian Y, Ding J, Chen Z, Zhao R, Lu Y, Li L, Zhang H, Wu H, Li X, Zhang Y
Int J Surg 2024 Sep 1;110(9):5385-5395. doi: 10.1097/JS9.0000000000001685. PMID: 38775562Free PMC Article
Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
A randomized phase II trial of everolimus and letrozole or hormonal therapy in women with advanced, persistent or recurrent endometrial carcinoma: A GOG Foundation study.
Slomovitz BM, Filiaci VL, Walker JL, Taub MC, Finkelstein KA, Moroney JW, Fleury AC, Muller CY, Holman LL, Copeland LJ, Miller DS, Coleman RL
Gynecol Oncol 2022 Mar;164(3):481-491. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2021.12.031. PMID: 35063278
Uterine serous carcinoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer.
Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Banerjee S, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, Lowe ES, Bloomfield R, DiSilvestro P
N Engl J Med 2018 Dec 27;379(26):2495-2505. Epub 2018 Oct 21 doi: 10.1056/NEJMoa1810858. PMID: 30345884

Prognosis

FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives.
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Uterine serous carcinoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article

Clinical prediction guides

Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis.
Shen Y, Tian Y, Ding J, Chen Z, Zhao R, Lu Y, Li L, Zhang H, Wu H, Li X, Zhang Y
Int J Surg 2024 Sep 1;110(9):5385-5395. doi: 10.1097/JS9.0000000000001685. PMID: 38775562Free PMC Article
Integration of clinical sequencing and immunohistochemistry for the molecular classification of endometrial carcinoma.
Rios-Doria E, Momeni-Boroujeni A, Friedman CF, Selenica P, Zhou Q, Wu M, Marra A, Leitao MM Jr, Iasonos A, Alektiar KM, Sonoda Y, Makker V, Jewell E, Liu Y, Chi D, Zamarin D, Abu-Rustum NR, Aghajanian C, Mueller JJ, Ellenson LH, Weigelt B
Gynecol Oncol 2023 Jul;174:262-272. Epub 2023 May 26 doi: 10.1016/j.ygyno.2023.05.059. PMID: 37245486Free PMC Article
A randomized phase II trial of everolimus and letrozole or hormonal therapy in women with advanced, persistent or recurrent endometrial carcinoma: A GOG Foundation study.
Slomovitz BM, Filiaci VL, Walker JL, Taub MC, Finkelstein KA, Moroney JW, Fleury AC, Muller CY, Holman LL, Copeland LJ, Miller DS, Coleman RL
Gynecol Oncol 2022 Mar;164(3):481-491. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2021.12.031. PMID: 35063278
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Molecular characterization of endometrial cancer and therapeutic implications.
Winterhoff B, Thomaier L, Mullany S, Powell MA
Curr Opin Obstet Gynecol 2020 Feb;32(1):76-83. doi: 10.1097/GCO.0000000000000602. PMID: 31851045

Recent systematic reviews

Cytoreductive surgery for advanced epithelial ovarian cancer in the poly(ADP-ribose) polymerase inhibitors era-Is it time for a new paradigm shift? A systematic review and meta-analysis.
Peters ITA, Marchetti C, De Palma A, Giannarelli D, Carcagnì A, Scambia G, Fagotti A
Eur J Cancer 2023 Jul;187:77-86. Epub 2023 Apr 5 doi: 10.1016/j.ejca.2023.03.035. PMID: 37130463
Endometrial cancer after endometrial ablation: a systematic review.
Oderkerk TJ, van de Kar MRD, Cornel KMC, Bongers MY, Geomini PMAJ
Int J Gynecol Cancer 2022 Dec 5;32(12):1555-1560. doi: 10.1136/ijgc-2022-003866. PMID: 36375895
Diagnostic accuracy of HNF1β, Napsin A and P504S/Alpha-Methylacyl-CoA Racemase (AMACR) as markers of endometrial clear cell carcinoma.
Travaglino A, Raffone A, Arciuolo D, Santoro A, Inzani F, Di Maio A, Visiello U, Fulgione C, Guida M, Mollo A, Insabato L, Zannoni GF
Pathol Res Pract 2022 Sep;237:154019. Epub 2022 Jul 13 doi: 10.1016/j.prp.2022.154019. PMID: 35907281
Prognostic significance of CTNNB1 mutation in early stage endometrial carcinoma: a systematic review and meta-analysis.
Travaglino A, Raffone A, Raimondo D, Reppuccia S, Ruggiero A, Arena A, Casadio P, Zullo F, Insabato L, Seracchioli R, Mollo A
Arch Gynecol Obstet 2022 Aug;306(2):423-431. Epub 2022 Jan 16 doi: 10.1007/s00404-021-06385-0. PMID: 35034160Free PMC Article
Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article

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