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Pancreatic Poorly Cohesive Adenocarcinoma

MedGen UID:
1754718
•Concept ID:
C5419872
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the pancreas and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Poorly Cohesive Adenocarcinoma

Recent clinical studies

Etiology

Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells.
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Distinct clinicopathological differences between early gastric cardiac and non-cardiac carcinomas: a single-center retrospective study of 329 radical resection cases.
Wang Y, Li X, Gao L, Wang C, Zhang Y, Huang Q
BMC Gastroenterol 2020 Oct 21;20(1):351. doi: 10.1186/s12876-020-01498-3. PMID: 33087057Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Endoscopic ultrasound-guided fine needle aspiration cytology of pancreatic neuroendocrine tumours: cytomorphological and immunocytochemical evaluation.
Chang F, Vu C, Chandra A, Meenan J, Herbert A
Cytopathology 2006 Feb;17(1):10-7. doi: 10.1111/j.1365-2303.2006.00311.x. PMID: 16417560
Fine needle aspiration cytology of endocrine neoplasms of the pancreas. Morphologic and immunocytochemical findings in 20 cases.
Jiménez-Heffernan JA, Vicandi B, López-Ferrer P, González-Peramato P, Pérez-Campos A, Viguer JM
Acta Cytol 2004 May-Jun;48(3):295-301. doi: 10.1159/000326376. PMID: 15192942

Diagnosis

Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology.
Bazzichetto C, Luchini C, Conciatori F, Vaccaro V, Di Cello I, Mattiolo P, Falcone I, Ferretti G, Scarpa A, Cognetti F, Milella M
Int J Mol Sci 2020 Nov 22;21(22) doi: 10.3390/ijms21228841. PMID: 33266496Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Diffuse Large B-Cell Lymphoma With Striking Intrasinusoidal Pseudoglandular Growth Pattern as a Diagnostic Dilemma Mimicking Metastatic Poorly Differentiated Pancreatic Adenocarcinoma in an Intraabdominal Lymph Node.
Yau D, Aron M, Siddiqi IN
Int J Surg Pathol 2019 Apr;27(2):181-184. Epub 2018 Nov 4 doi: 10.1177/1066896918810866. PMID: 30392418
Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
Fine needle aspiration cytology of endocrine neoplasms of the pancreas. Morphologic and immunocytochemical findings in 20 cases.
Jiménez-Heffernan JA, Vicandi B, López-Ferrer P, González-Peramato P, Pérez-Campos A, Viguer JM
Acta Cytol 2004 May-Jun;48(3):295-301. doi: 10.1159/000326376. PMID: 15192942

Therapy

Emphysematous gastritis associated with gastric cancer: a rare and fatal entity.
Fonseca MR, Constante M, Moura A, Melo Valadão I
BMJ Case Rep 2019 Dec 2;12(12) doi: 10.1136/bcr-2019-231796. PMID: 31796461Free PMC Article

Prognosis

Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells.
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Poorly Cohesive (Signet Ring Cell) Carcinoma of the Ampulla of Vater.
Tuncel D, Basturk O, Bradley KT, Kim GE, Xue Y, Reid MD, Balci S, Erbarut I, Adsay V
Int J Surg Pathol 2020 May;28(3):236-244. Epub 2019 Oct 15 doi: 10.1177/1066896919880968. PMID: 31612756
Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
SMARCB1/INI1 missense mutation in mucinous carcinoma with rhabdoid features.
Cho YM, Choi J, Lee OJ, Lee HI, Han DJ, Ro JY
Pathol Int 2006 Nov;56(11):702-6. doi: 10.1111/j.1440-1827.2006.02033.x. PMID: 17040295

Clinical prediction guides

Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.
Chiaravalli AM, Finzi G, Bertolini V, La Rosa S, Capella C
Virchows Arch 2009 Dec;455(6):527-31. Epub 2009 Nov 12 doi: 10.1007/s00428-009-0852-5. PMID: 19908063
Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer.
Winter JM, Ting AH, Vilardell F, Gallmeier E, Baylin SB, Hruban RH, Kern SE, Iacobuzio-Donahue CA
Clin Cancer Res 2008 Jan 15;14(2):412-8. doi: 10.1158/1078-0432.CCR-07-0487. PMID: 18223216Free PMC Article
Review of the cytologic features of noninvasive ductal carcinomas of the pancreas: differences from invasive ductal carcinoma.
Hara H, Suda K
Am J Clin Pathol 2008 Jan;129(1):115-29. doi: 10.1309/PHV2244LC8B0P7TR. PMID: 18089497

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