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Pancreatic ductal adenocarcinoma

MedGen UID:
277490
•Concept ID:
C1335302
•
Neoplastic Process
Synonym: Pancreatic tubular adenocarcinoma
SNOMED CT: Pancreatic ductal adenocarcinoma (792907004); Ductal adenocarcinoma of pancreas (792907004); Adenocarcinoma of pancreatic duct (792907004); PDAC - pancreatic ductal adenocarcinoma (792907004)
 
Monarch Initiative: MONDO:0005184

Definition

An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor. [from NCI]

Professional guidelines

PubMed

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article

Recent clinical studies

Etiology

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Imaging and Screening of Pancreatic Cancer.
Burk KS, Lo GC, Gee MS, Sahani DV
Radiol Clin North Am 2017 Nov;55(6):1223-1234. doi: 10.1016/j.rcl.2017.06.006. PMID: 28991562
Surgery for pancreatic ductal adenocarcinoma.
Vera R, Díez L, Martín Pérez E, Plaza JC, Sanjuanbenito A, Carrato A
Clin Transl Oncol 2017 Nov;19(11):1303-1311. Epub 2017 Jun 23 doi: 10.1007/s12094-017-1688-0. PMID: 28646282
Diagnosis and staging of pancreatic ductal adenocarcinoma.
Guillén-Ponce C, Blázquez J, González I, de-Madaria E, Montáns J, Carrato A
Clin Transl Oncol 2017 Oct;19(10):1205-1216. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1681-7. PMID: 28612200

Diagnosis

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Syndecans and Pancreatic Ductal Adenocarcinoma.
Betriu N, Bertran-Mas J, Andreeva A, Semino CE
Biomolecules 2021 Feb 25;11(3) doi: 10.3390/biom11030349. PMID: 33669066Free PMC Article
Microbiome and pancreatic ductal adenocarcinoma.
Tijeras-Raballand A, Hilmi M, Astorgues-Xerri L, Nicolle R, Bièche I, Neuzillet C
Clin Res Hepatol Gastroenterol 2021 Mar;45(2):101589. Epub 2021 Feb 16 doi: 10.1016/j.clinre.2020.101589. PMID: 33607375
Rare pancreatic tumors.
Steinman J, Zaheer A, Kluger MD, Remotti H, Hecht EM
Abdom Radiol (NY) 2018 Feb;43(2):285-300. doi: 10.1007/s00261-017-1342-x. PMID: 29022085
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.
Storz P
Nat Rev Gastroenterol Hepatol 2017 May;14(5):296-304. Epub 2017 Mar 8 doi: 10.1038/nrgastro.2017.12. PMID: 28270694Free PMC Article

Therapy

Therapeutic developments in pancreatic cancer.
Hu ZI, O'Reilly EM
Nat Rev Gastroenterol Hepatol 2024 Jan;21(1):7-24. Epub 2023 Oct 5 doi: 10.1038/s41575-023-00840-w. PMID: 37798442
NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3 trial.
Wainberg ZA, Melisi D, Macarulla T, Pazo Cid R, Chandana SR, De La Fouchardière C, Dean A, Kiss I, Lee WJ, Goetze TO, Van Cutsem E, Paulson AS, Bekaii-Saab T, Pant S, Hubner RA, Xiao Z, Chen H, Benzaghou F, O'Reilly EM
Lancet 2023 Oct 7;402(10409):1272-1281. Epub 2023 Sep 11 doi: 10.1016/S0140-6736(23)01366-1. PMID: 37708904
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma.
Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C
J Hematol Oncol 2020 Oct 2;13(1):130. doi: 10.1186/s13045-020-00958-3. PMID: 33008426Free PMC Article
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors.
Wang-Gillam A, Hubner RA, Siveke JT, Von Hoff DD, Belanger B, de Jong FA, Mirakhur B, Chen LT
Eur J Cancer 2019 Feb;108:78-87. Epub 2019 Jan 14 doi: 10.1016/j.ejca.2018.12.007. PMID: 30654298

Prognosis

Pancreatic cancer: A review of epidemiology, trend, and risk factors.
Hu JX, Zhao CF, Chen WB, Liu QC, Li QW, Lin YY, Gao F
World J Gastroenterol 2021 Jul 21;27(27):4298-4321. doi: 10.3748/wjg.v27.i27.4298. PMID: 34366606Free PMC Article
Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research.
Cloyd JM, Tsung A, Hays J, Wills CE, Bridges JF
World J Gastroenterol 2020 Jan 28;26(4):375-382. doi: 10.3748/wjg.v26.i4.375. PMID: 32063686Free PMC Article
Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies.
Ayres Pereira M, Chio IIC
Genes (Basel) 2019 Dec 19;11(1) doi: 10.3390/genes11010006. PMID: 31861620Free PMC Article
The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.
Tesfaye AA, Kamgar M, Azmi A, Philip PA
Expert Rev Anticancer Ther 2018 Feb;18(2):131-148. Epub 2017 Dec 19 doi: 10.1080/14737140.2018.1417844. PMID: 29254387Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants.
Luchini C, Capelli P, Scarpa A
Surg Pathol Clin 2016 Dec;9(4):547-560. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.003. PMID: 27926359

Clinical prediction guides

Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma.
George B, Kudryashova O, Kravets A, Thalji S, Malarkannan S, Kurzrock R, Chernyavskaya E, Gusakova M, Kravchenko D, Tychinin D, Savin E, Alekseeva L, Butusova A, Bagaev A, Shin N, Brown JH, Sethi I, Wang D, Taylor B, McFall T, Kamgar M, Hall WA, Erickson B, Christians KK, Evans DB, Tsai S
Gastroenterology 2024 May;166(5):859-871.e3. Epub 2024 Jan 25 doi: 10.1053/j.gastro.2024.01.028. PMID: 38280684
Predicting Pancreatic Cancer in the UK Biobank Cohort Using Polygenic Risk Scores and Diabetes Mellitus.
Sharma S, Tapper WJ, Collins A, Hamady ZZR
Gastroenterology 2022 May;162(6):1665-1674.e2. Epub 2022 Jan 21 doi: 10.1053/j.gastro.2022.01.016. PMID: 35065983
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Early Detection of Pancreatic Cancer: Opportunities and Challenges.
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
Glycoproteins and glycoproteomics in pancreatic cancer.
Pan S, Brentnall TA, Chen R
World J Gastroenterol 2016 Nov 14;22(42):9288-9299. doi: 10.3748/wjg.v22.i42.9288. PMID: 27895417Free PMC Article

Recent systematic reviews

NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Pathology of Treated Pancreatic Ductal Adenocarcinoma and Its Clinical Implications.
Nagaria TS, Wang H, Chatterjee D, Wang H
Arch Pathol Lab Med 2020 Jul 1;144(7):838-845. doi: 10.5858/arpa.2019-0477-RA. PMID: 32023088Free PMC Article
A systematic review of economic evaluation in pancreatic ductal adenocarcinoma.
Gérard C, Fagnoni P, Vienot A, Borg C, Limat S, Daval F, Calais F, Vardanega J, Jary M, Nerich V
Eur J Cancer 2017 Nov;86:207-216. Epub 2017 Oct 9 doi: 10.1016/j.ejca.2017.08.035. PMID: 29024890
Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma.
Petrushnko W, Gundara JS, De Reuver PR, O'Grady G, Samra JS, Mittal A
HPB (Oxford) 2016 Aug;18(8):652-63. Epub 2016 Jul 14 doi: 10.1016/j.hpb.2016.05.004. PMID: 27485059Free PMC Article
Cytokines as Biomarkers of Pancreatic Ductal Adenocarcinoma: A Systematic Review.
Yako YY, Kruger D, Smith M, Brand M
PLoS One 2016;11(5):e0154016. Epub 2016 May 12 doi: 10.1371/journal.pone.0154016. PMID: 27170998Free PMC Article

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