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Advanced Glioblastoma

MedGen UID:
1758465
•Concept ID:
C5418921
•
Neoplastic Process

Definition

Glioblastoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Glioblastoma

Professional guidelines

PubMed

Expert opinion on translational research for advanced glioblastoma treatment.
Cui X, Wang Y, Zhou J, Wang Q, Kang C
Cancer Biol Med 2023 Apr 25;20(5):344-52. doi: 10.20892/j.issn.2095-3941.2023.0012. PMID: 37092846Free PMC Article
A multi‑targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma.
Li J, Zou CL, Zhang ZM, Lv LJ, Qiao HB, Chen XJ
Mol Med Rep 2017 Nov;16(5):7105-7111. Epub 2017 Sep 11 doi: 10.3892/mmr.2017.7456. PMID: 28901423

Recent clinical studies

Etiology

Correlation between MGMT promoter methylation and response to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study.
Campana D, Walter T, Pusceddu S, Gelsomino F, Graillot E, Prinzi N, Spallanzani A, Fiorentino M, Barritault M, Dall'Olio F, Brighi N, Biasco G
Endocrine 2018 Jun;60(3):490-498. Epub 2017 Nov 17 doi: 10.1007/s12020-017-1474-3. PMID: 29150792
Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme.
Raymond E, Campone M, Stupp R, Menten J, Chollet P, Lesimple T, Fety-Deporte R, Lacombe D, Paoletti X, Fumoleau P; EORTC Early Clinical Studies Group (ECSG); Brain Tumor Studies Group (BTSG); New Drug Development Program (NDDP)
Eur J Cancer 2002 Jul;38(10):1348-50. doi: 10.1016/s0959-8049(02)00070-9. PMID: 12091065

Diagnosis

Expert opinion on translational research for advanced glioblastoma treatment.
Cui X, Wang Y, Zhou J, Wang Q, Kang C
Cancer Biol Med 2023 Apr 25;20(5):344-52. doi: 10.20892/j.issn.2095-3941.2023.0012. PMID: 37092846Free PMC Article
ACT001 modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth.
Li Q, Sun Y, Liu B, Li J, Hao X, Ge W, Zhang X, Bao S, Gong J, Jiang Z, Qiu C, Zhao L, Zhao Y, Chen Y, Yang X, Ding Y, Wu Z
J Mol Med (Berl) 2020 Feb;98(2):263-277. Epub 2020 Jan 4 doi: 10.1007/s00109-019-01839-0. PMID: 31901951

Therapy

Expert opinion on translational research for advanced glioblastoma treatment.
Cui X, Wang Y, Zhou J, Wang Q, Kang C
Cancer Biol Med 2023 Apr 25;20(5):344-52. doi: 10.20892/j.issn.2095-3941.2023.0012. PMID: 37092846Free PMC Article
SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy.
Park YK, Jangili P, Zi S, Kang RH, Kim D, Kim JS
Chem Commun (Camb) 2022 Sep 29;58(78):10941-10944. doi: 10.1039/d2cc03777g. PMID: 36082694
ACT001 modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth.
Li Q, Sun Y, Liu B, Li J, Hao X, Ge W, Zhang X, Bao S, Gong J, Jiang Z, Qiu C, Zhao L, Zhao Y, Chen Y, Yang X, Ding Y, Wu Z
J Mol Med (Berl) 2020 Feb;98(2):263-277. Epub 2020 Jan 4 doi: 10.1007/s00109-019-01839-0. PMID: 31901951
IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma.
Ladomersky E, Zhai L, Lenzen A, Lauing KL, Qian J, Scholtens DM, Gritsina G, Sun X, Liu Y, Yu F, Gong W, Liu Y, Jiang B, Tang T, Patel R, Platanias LC, James CD, Stupp R, Lukas RV, Binder DC, Wainwright DA
Clin Cancer Res 2018 Jun 1;24(11):2559-2573. Epub 2018 Mar 2 doi: 10.1158/1078-0432.CCR-17-3573. PMID: 29500275Free PMC Article
Granulomatous and lichenoid dermatitis after IgG4 anti-PD-1 monoclonal antibody therapy for advanced cancer.
Diaz-Perez JA, Beveridge MG, Victor TA, Cibull TL
J Cutan Pathol 2018 Jun;45(6):434-438. Epub 2018 Apr 2 doi: 10.1111/cup.13133. PMID: 29468713

Prognosis

Expert opinion on translational research for advanced glioblastoma treatment.
Cui X, Wang Y, Zhou J, Wang Q, Kang C
Cancer Biol Med 2023 Apr 25;20(5):344-52. doi: 10.20892/j.issn.2095-3941.2023.0012. PMID: 37092846Free PMC Article
ACT001 modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth.
Li Q, Sun Y, Liu B, Li J, Hao X, Ge W, Zhang X, Bao S, Gong J, Jiang Z, Qiu C, Zhao L, Zhao Y, Chen Y, Yang X, Ding Y, Wu Z
J Mol Med (Berl) 2020 Feb;98(2):263-277. Epub 2020 Jan 4 doi: 10.1007/s00109-019-01839-0. PMID: 31901951
Correlation between MGMT promoter methylation and response to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study.
Campana D, Walter T, Pusceddu S, Gelsomino F, Graillot E, Prinzi N, Spallanzani A, Fiorentino M, Barritault M, Dall'Olio F, Brighi N, Biasco G
Endocrine 2018 Jun;60(3):490-498. Epub 2017 Nov 17 doi: 10.1007/s12020-017-1474-3. PMID: 29150792
A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease.
Wagoner MP, Roopra A
BMC Genomics 2012 Dec 7;13:686. doi: 10.1186/1471-2164-13-686. PMID: 23216891Free PMC Article

Clinical prediction guides

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma.
Ladomersky E, Zhai L, Lenzen A, Lauing KL, Qian J, Scholtens DM, Gritsina G, Sun X, Liu Y, Yu F, Gong W, Liu Y, Jiang B, Tang T, Patel R, Platanias LC, James CD, Stupp R, Lukas RV, Binder DC, Wainwright DA
Clin Cancer Res 2018 Jun 1;24(11):2559-2573. Epub 2018 Mar 2 doi: 10.1158/1078-0432.CCR-17-3573. PMID: 29500275Free PMC Article
Granulomatous and lichenoid dermatitis after IgG4 anti-PD-1 monoclonal antibody therapy for advanced cancer.
Diaz-Perez JA, Beveridge MG, Victor TA, Cibull TL
J Cutan Pathol 2018 Jun;45(6):434-438. Epub 2018 Apr 2 doi: 10.1111/cup.13133. PMID: 29468713
Correlation between MGMT promoter methylation and response to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study.
Campana D, Walter T, Pusceddu S, Gelsomino F, Graillot E, Prinzi N, Spallanzani A, Fiorentino M, Barritault M, Dall'Olio F, Brighi N, Biasco G
Endocrine 2018 Jun;60(3):490-498. Epub 2017 Nov 17 doi: 10.1007/s12020-017-1474-3. PMID: 29150792
A multi‑targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma.
Li J, Zou CL, Zhang ZM, Lv LJ, Qiao HB, Chen XJ
Mol Med Rep 2017 Nov;16(5):7105-7111. Epub 2017 Sep 11 doi: 10.3892/mmr.2017.7456. PMID: 28901423
A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease.
Wagoner MP, Roopra A
BMC Genomics 2012 Dec 7;13:686. doi: 10.1186/1471-2164-13-686. PMID: 23216891Free PMC Article

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    Practice guidelines

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