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Advanced Platinum-Resistant Malignant Germ Cell Tumor

MedGen UID:
1759834
•Concept ID:
C5418903
•
Neoplastic Process

Definition

A platinum-resistant malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Platinum-Resistant Malignant Germ Cell Tumor

Professional guidelines

PubMed

Treatment of refractory germ-cell tumours with single-agent cabazitaxel: a German Testicular Cancer Study Group case series.
Oing C, Hentrich M, Lorch A, Gläser D, Rumpold H, Ochsenreither S, Richter S, Dieing A, Zschäbitz S, Pereira RR, Bokemeyer C, Seidel C
J Cancer Res Clin Oncol 2020 Feb;146(2):449-455. Epub 2019 Dec 14 doi: 10.1007/s00432-019-03071-2. PMID: 31838576
Current controversies in the management of germ cell ovarian tumours.
Vazquez I, Rustin GJ
Curr Opin Oncol 2013 Sep;25(5):539-45. doi: 10.1097/01.cco.0000432609.39293.77. PMID: 23942298

Recent clinical studies

Etiology

Treatment of refractory germ-cell tumours with single-agent cabazitaxel: a German Testicular Cancer Study Group case series.
Oing C, Hentrich M, Lorch A, Gläser D, Rumpold H, Ochsenreither S, Richter S, Dieing A, Zschäbitz S, Pereira RR, Bokemeyer C, Seidel C
J Cancer Res Clin Oncol 2020 Feb;146(2):449-455. Epub 2019 Dec 14 doi: 10.1007/s00432-019-03071-2. PMID: 31838576
New insights into germ cell tumor genomics.
Lafin JT, Bagrodia A, Woldu S, Amatruda JF
Andrology 2019 Jul;7(4):507-515. Epub 2019 Mar 21 doi: 10.1111/andr.12616. PMID: 30896089
Current controversies in the management of germ cell ovarian tumours.
Vazquez I, Rustin GJ
Curr Opin Oncol 2013 Sep;25(5):539-45. doi: 10.1097/01.cco.0000432609.39293.77. PMID: 23942298
Late relapses (>2 years) in patients with stage I testicular germ cell tumors: predictive factors and survival.
Fedyanin M, Tryakin A, Kanagavel D, Bulanov A, Burova A, Figurin K, Fainshtein I, Sergeev U, Zakharova T, Garin A, Tjulandin S
Urol Oncol 2013 May;31(4):499-504. Epub 2011 Jul 30 doi: 10.1016/j.urolonc.2011.06.001. PMID: 21803619

Diagnosis

Current controversies in the management of germ cell ovarian tumours.
Vazquez I, Rustin GJ
Curr Opin Oncol 2013 Sep;25(5):539-45. doi: 10.1097/01.cco.0000432609.39293.77. PMID: 23942298
Update on malignant ovarian germ cell tumors.
Gershenson DM
Cancer 1993 Feb 15;71(4 Suppl):1581-90. doi: 10.1002/cncr.2820710425. PMID: 8381708

Therapy

Treatment of refractory germ-cell tumours with single-agent cabazitaxel: a German Testicular Cancer Study Group case series.
Oing C, Hentrich M, Lorch A, Gläser D, Rumpold H, Ochsenreither S, Richter S, Dieing A, Zschäbitz S, Pereira RR, Bokemeyer C, Seidel C
J Cancer Res Clin Oncol 2020 Feb;146(2):449-455. Epub 2019 Dec 14 doi: 10.1007/s00432-019-03071-2. PMID: 31838576
Current controversies in the management of germ cell ovarian tumours.
Vazquez I, Rustin GJ
Curr Opin Oncol 2013 Sep;25(5):539-45. doi: 10.1097/01.cco.0000432609.39293.77. PMID: 23942298
Oxaliplatin in tumors other than colorectal cancer.
Lorusso PM
Oncology (Williston Park) 2000 Dec;14(12 Suppl 11):33-7. PMID: 11204661
Advances in the chemotherapy of gynecologic cancer.
Neijt JP
Curr Opin Oncol 1994 Sep;6(5):531-8. doi: 10.1097/00001622-199409000-00015. PMID: 7827159
Update on malignant ovarian germ cell tumors.
Gershenson DM
Cancer 1993 Feb 15;71(4 Suppl):1581-90. doi: 10.1002/cncr.2820710425. PMID: 8381708

Prognosis

Current controversies in the management of germ cell ovarian tumours.
Vazquez I, Rustin GJ
Curr Opin Oncol 2013 Sep;25(5):539-45. doi: 10.1097/01.cco.0000432609.39293.77. PMID: 23942298
Late relapses (>2 years) in patients with stage I testicular germ cell tumors: predictive factors and survival.
Fedyanin M, Tryakin A, Kanagavel D, Bulanov A, Burova A, Figurin K, Fainshtein I, Sergeev U, Zakharova T, Garin A, Tjulandin S
Urol Oncol 2013 May;31(4):499-504. Epub 2011 Jul 30 doi: 10.1016/j.urolonc.2011.06.001. PMID: 21803619
Advances in the chemotherapy of gynecologic cancer.
Neijt JP
Curr Opin Oncol 1994 Sep;6(5):531-8. doi: 10.1097/00001622-199409000-00015. PMID: 7827159

Clinical prediction guides

Late relapses (>2 years) in patients with stage I testicular germ cell tumors: predictive factors and survival.
Fedyanin M, Tryakin A, Kanagavel D, Bulanov A, Burova A, Figurin K, Fainshtein I, Sergeev U, Zakharova T, Garin A, Tjulandin S
Urol Oncol 2013 May;31(4):499-504. Epub 2011 Jul 30 doi: 10.1016/j.urolonc.2011.06.001. PMID: 21803619
Advances in the chemotherapy of gynecologic cancer.
Neijt JP
Curr Opin Oncol 1994 Sep;6(5):531-8. doi: 10.1097/00001622-199409000-00015. PMID: 7827159

Supplemental Content

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