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COVID-19-Associated Pneumonia

MedGen UID:
1771437
•Concept ID:
C5419163
•
Disease or Syndrome
Synonym: SARS-CoV-2 -Associated Pneumonia

Definition

Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by the presence of ground glass opacities on CT scan images. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCOVID-19-Associated Pneumonia

Professional guidelines

PubMed

Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls.
Mert A, Vahaboğlu H, Arslan F, Batirel A, Saraçoğlu KT, Bastug A, Çağatay A, Irmak İ, Dizman GT, Ertenli İ, Altunal LN, Sengel BE, Bayram M, Omma A, Amikishiyev S, Aypak A, Bes C, Bolukçu S, Içten S, Topeli A, Bektaş M, Arslan BY, Öztürk S, Çomoğlu Ş, Aydin S, Küçükşahin O, Içaçan OC, Ince B, Aghamuradov S, Mutlu MY, Şimşek F, Emre S, Ustun C, Ergen P, Aydin Ö, Koç MM, Sevindik ÖG, Odabaşı Z, Korten V, Bodur H, Güner R, Ünal S, Kocak M, Gül A
Rheumatol Int 2022 Mar;42(3):457-467. Epub 2021 Sep 13 doi: 10.1007/s00296-021-04965-6. PMID: 34515808Free PMC Article
Incidental CT Findings Suspicious for COVID-19-Associated Pneumonia on Nuclear Medicine Examinations: Recognition and Management Plan.
Tulchinsky M, Fotos JS, Slonimsky E
Clin Nucl Med 2020 Jul;45(7):531-533. doi: 10.1097/RLU.0000000000003100. PMID: 32502091Free PMC Article
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.
Gao J, Tian Z, Yang X
Biosci Trends 2020 Mar 16;14(1):72-73. Epub 2020 Feb 19 doi: 10.5582/bst.2020.01047. PMID: 32074550

Recent clinical studies

Etiology

DFV890: a new oral NLRP3 inhibitor-tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function.
Madurka I, Vishnevsky A, Soriano JB, Gans SJ, Ore DJS, Rendon A, Ulrik CS, Bhatnagar S, Krishnamurthy S, Mc Harry K, Welte T, Fernandez AA, Mehes B, Meiser K, Gatlik E, Sommer U, Junge G, Rezende E; Study group
Infection 2023 Jun;51(3):641-654. Epub 2022 Sep 14 doi: 10.1007/s15010-022-01904-w. PMID: 36104613Free PMC Article
COVID-19-associated Mucormycosis: A clinico-epidemiological study.
Chakravarty J, Gupta MK, Tilak R, Kumar R, Maurya RP, Kumar N, Aggarwal SK, S S, Sharma NK, Dhiman NK, Chaubey M, Singh V, Verma A, Banerjee T, Agrawal NK, Prasad RS
J Diabetes Complications 2022 Sep;36(9):108284. Epub 2022 Aug 13 doi: 10.1016/j.jdiacomp.2022.108284. PMID: 35987108Free PMC Article
Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis.
Ammirati E, Lupi L, Palazzini M, Hendren NS, Grodin JL, Cannistraci CV, Schmidt M, Hekimian G, Peretto G, Bochaton T, Hayek A, Piriou N, Leonardi S, Guida S, Turco A, Sala S, Uribarri A, Van de Heyning CM, Mapelli M, Campodonico J, Pedrotti P, Barrionuevo Sánchez MI, Ariza Sole A, Marini M, Matassini MV, Vourc'h M, Cannatà A, Bromage DI, Briguglia D, Salamanca J, Diez-Villanueva P, Lehtonen J, Huang F, Russel S, Soriano F, Turrini F, Cipriani M, Bramerio M, Di Pasquale M, Grosu A, Senni M, Farina D, Agostoni P, Rizzo S, De Gaspari M, Marzo F, Duran JM, Adler ED, Giannattasio C, Basso C, McDonagh T, Kerneis M, Combes A, Camici PG, de Lemos JA, Metra M
Circulation 2022 Apr 12;145(15):1123-1139. Epub 2022 Apr 11 doi: 10.1161/CIRCULATIONAHA.121.056817. PMID: 35404682Free PMC Article
COVID-19 and Immunological Dysregulation: Can Autoantibodies be Useful?
Pascolini S, Vannini A, Deleonardi G, Ciordinik M, Sensoli A, Carletti I, Veronesi L, Ricci C, Pronesti A, Mazzanti L, Grondona A, Silvestri T, Zanuso S, Mazzolini M, Lalanne C, Quarneti C, Fusconi M, Giostra F, Granito A, Muratori L, Lenzi M, Muratori P
Clin Transl Sci 2021 Mar;14(2):502-508. Epub 2021 Jan 20 doi: 10.1111/cts.12908. PMID: 32989903Free PMC Article
Tocilizumab use in COVID-19-associated pneumonia.
Okoh AK, Bishburg E, Grinberg S, Nagarakanti S
J Med Virol 2021 Feb;93(2):1023-1028. Epub 2020 Oct 5 doi: 10.1002/jmv.26471. PMID: 32860432

Diagnosis

COVID-19-associated Mucormycosis: A clinico-epidemiological study.
Chakravarty J, Gupta MK, Tilak R, Kumar R, Maurya RP, Kumar N, Aggarwal SK, S S, Sharma NK, Dhiman NK, Chaubey M, Singh V, Verma A, Banerjee T, Agrawal NK, Prasad RS
J Diabetes Complications 2022 Sep;36(9):108284. Epub 2022 Aug 13 doi: 10.1016/j.jdiacomp.2022.108284. PMID: 35987108Free PMC Article
Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis.
Ammirati E, Lupi L, Palazzini M, Hendren NS, Grodin JL, Cannistraci CV, Schmidt M, Hekimian G, Peretto G, Bochaton T, Hayek A, Piriou N, Leonardi S, Guida S, Turco A, Sala S, Uribarri A, Van de Heyning CM, Mapelli M, Campodonico J, Pedrotti P, Barrionuevo Sánchez MI, Ariza Sole A, Marini M, Matassini MV, Vourc'h M, Cannatà A, Bromage DI, Briguglia D, Salamanca J, Diez-Villanueva P, Lehtonen J, Huang F, Russel S, Soriano F, Turrini F, Cipriani M, Bramerio M, Di Pasquale M, Grosu A, Senni M, Farina D, Agostoni P, Rizzo S, De Gaspari M, Marzo F, Duran JM, Adler ED, Giannattasio C, Basso C, McDonagh T, Kerneis M, Combes A, Camici PG, de Lemos JA, Metra M
Circulation 2022 Apr 12;145(15):1123-1139. Epub 2022 Apr 11 doi: 10.1161/CIRCULATIONAHA.121.056817. PMID: 35404682Free PMC Article
Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?
Liu JM, Chi J
Exp Biol Med (Maywood) 2022 Feb;247(4):330-337. Epub 2022 Jan 22 doi: 10.1177/15353702211068840. PMID: 35068219Free PMC Article
COVID-19 pneumonia: What APRNs should know.
Avadhani A, Cardinale M, Akintade B
Nurse Pract 2021 Jul 1;46(7):22-28. doi: 10.1097/01.NPR.0000753828.91626.a1. PMID: 34138809
COVID-19 Associated Pneumonia: A review of chest radiograph and computed tomography findings.
Al-Umairi RS, Al-Kalbani J, Al-Tai S, Al-Abri A, Al-Kindi F, Kamona A
Sultan Qaboos Univ Med J 2021 Feb;21(1):e4-e11. Epub 2021 Mar 15 doi: 10.18295/squmj.2021.21.01.002. PMID: 33777418Free PMC Article

Therapy

DFV890: a new oral NLRP3 inhibitor-tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function.
Madurka I, Vishnevsky A, Soriano JB, Gans SJ, Ore DJS, Rendon A, Ulrik CS, Bhatnagar S, Krishnamurthy S, Mc Harry K, Welte T, Fernandez AA, Mehes B, Meiser K, Gatlik E, Sommer U, Junge G, Rezende E; Study group
Infection 2023 Jun;51(3):641-654. Epub 2022 Sep 14 doi: 10.1007/s15010-022-01904-w. PMID: 36104613Free PMC Article
COVID-19-associated Mucormycosis: A clinico-epidemiological study.
Chakravarty J, Gupta MK, Tilak R, Kumar R, Maurya RP, Kumar N, Aggarwal SK, S S, Sharma NK, Dhiman NK, Chaubey M, Singh V, Verma A, Banerjee T, Agrawal NK, Prasad RS
J Diabetes Complications 2022 Sep;36(9):108284. Epub 2022 Aug 13 doi: 10.1016/j.jdiacomp.2022.108284. PMID: 35987108Free PMC Article
Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?
Liu JM, Chi J
Exp Biol Med (Maywood) 2022 Feb;247(4):330-337. Epub 2022 Jan 22 doi: 10.1177/15353702211068840. PMID: 35068219Free PMC Article
Tocilizumab use in COVID-19-associated pneumonia.
Okoh AK, Bishburg E, Grinberg S, Nagarakanti S
J Med Virol 2021 Feb;93(2):1023-1028. Epub 2020 Oct 5 doi: 10.1002/jmv.26471. PMID: 32860432
Pneumatosis intestinalis in COVID-19.
Meini S, Zini C, Passaleva MT, Frullini A, Fusco F, Carpi R, Piani F
BMJ Open Gastroenterol 2020 Jun;7(1) doi: 10.1136/bmjgast-2020-000434. PMID: 32522754Free PMC Article

Prognosis

Characteristics of COVID-19 Pneumonia Survivors With Resting Normoxemia and Exercise-Induced Desaturation.
Vitacca M, Paneroni M, Brunetti G, Carlucci A, Balbi B, Spanevello A, Ambrosino N
Respir Care 2021 Nov;66(11):1657-1664. Epub 2021 Aug 24 doi: 10.4187/respcare.09029. PMID: 34429351
Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia.
Liu G, Jiang X, Zeng X, Pan Y, Xu H
J Immunol Res 2021;2021:6657894. Epub 2021 Jun 9 doi: 10.1155/2021/6657894. PMID: 34150910Free PMC Article
Efficacy of copeptin in distinguishing COVID-19 pneumonia from community-acquired pneumonia.
Kuluöztürk M, İn E, Telo S, Karabulut E, Geçkil AA
J Med Virol 2021 May;93(5):3113-3121. Epub 2021 Feb 17 doi: 10.1002/jmv.26870. PMID: 33570194Free PMC Article
COVID-19 and Immunological Dysregulation: Can Autoantibodies be Useful?
Pascolini S, Vannini A, Deleonardi G, Ciordinik M, Sensoli A, Carletti I, Veronesi L, Ricci C, Pronesti A, Mazzanti L, Grondona A, Silvestri T, Zanuso S, Mazzolini M, Lalanne C, Quarneti C, Fusconi M, Giostra F, Granito A, Muratori L, Lenzi M, Muratori P
Clin Transl Sci 2021 Mar;14(2):502-508. Epub 2021 Jan 20 doi: 10.1111/cts.12908. PMID: 32989903Free PMC Article
Tocilizumab use in COVID-19-associated pneumonia.
Okoh AK, Bishburg E, Grinberg S, Nagarakanti S
J Med Virol 2021 Feb;93(2):1023-1028. Epub 2020 Oct 5 doi: 10.1002/jmv.26471. PMID: 32860432

Clinical prediction guides

DFV890: a new oral NLRP3 inhibitor-tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function.
Madurka I, Vishnevsky A, Soriano JB, Gans SJ, Ore DJS, Rendon A, Ulrik CS, Bhatnagar S, Krishnamurthy S, Mc Harry K, Welte T, Fernandez AA, Mehes B, Meiser K, Gatlik E, Sommer U, Junge G, Rezende E; Study group
Infection 2023 Jun;51(3):641-654. Epub 2022 Sep 14 doi: 10.1007/s15010-022-01904-w. PMID: 36104613Free PMC Article
COVID-19-associated Mucormycosis: A clinico-epidemiological study.
Chakravarty J, Gupta MK, Tilak R, Kumar R, Maurya RP, Kumar N, Aggarwal SK, S S, Sharma NK, Dhiman NK, Chaubey M, Singh V, Verma A, Banerjee T, Agrawal NK, Prasad RS
J Diabetes Complications 2022 Sep;36(9):108284. Epub 2022 Aug 13 doi: 10.1016/j.jdiacomp.2022.108284. PMID: 35987108Free PMC Article
Characteristics of COVID-19 Pneumonia Survivors With Resting Normoxemia and Exercise-Induced Desaturation.
Vitacca M, Paneroni M, Brunetti G, Carlucci A, Balbi B, Spanevello A, Ambrosino N
Respir Care 2021 Nov;66(11):1657-1664. Epub 2021 Aug 24 doi: 10.4187/respcare.09029. PMID: 34429351
Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia.
Liu G, Jiang X, Zeng X, Pan Y, Xu H
J Immunol Res 2021;2021:6657894. Epub 2021 Jun 9 doi: 10.1155/2021/6657894. PMID: 34150910Free PMC Article
Tocilizumab use in COVID-19-associated pneumonia.
Okoh AK, Bishburg E, Grinberg S, Nagarakanti S
J Med Virol 2021 Feb;93(2):1023-1028. Epub 2020 Oct 5 doi: 10.1002/jmv.26471. PMID: 32860432

Recent systematic reviews

Research Status of the Safety and Efficacy of Mesenchymal Stem Cells in the Treatment of COVID-19-Related Pneumonia: A Systematic Review and Meta-Analysis.
Wang J, Shi P, Chen D, Wang S, Wang P, Feng X, Zhang L
Stem Cells Dev 2021 Oct 1;30(19):947-969. doi: 10.1089/scd.2021.0179. PMID: 34416823

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