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Benign Lacrimal System Neoplasm

MedGen UID:: 1781905
•Concept ID:: C5446422
•: Neoplastic Process

Synonyms:	Benign Lacrimal Apparatus Neoplasm; Benign neoplasm of lacrimal apparatus
SNOMED CT:	Benign neoplasm of lacrimal apparatus (1196815001)

Definition

A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Lacrimal System Neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign Eye Neoplasm
        Benign Lacrimal System Neoplasm
        Benign Lacrimal Drainage System Neoplasm
        Benign Nasolacrimal Duct Neoplasm
        Lacrimal Drainage System Exophytic Papilloma
        Lacrimal Drainage System Inverted Papilloma
        Benign neoplasm of lacrimal gland
        Lacrimal Gland Myoepithelioma
        Lacrimal Gland Oncocytoma
        Lacrimal Gland Pleomorphic Adenoma
        Lacrimal Gland Warthin Tumor

Professional guidelines

PubMed

The forgotten lacrimal gland and lacrimal drainage apparatus: pictorial review of CT and MRI findings and differential diagnosis.

Nair JR, Syed R, Chan IYM, Gorelik N, Chankowsky J, Del Carpio-O'Donovan R
Br J Radiol 2022 Jul 1;95(1135):20211333. Epub 2022 May 19 doi: 10.1259/bjr.20211333. PMID: 35522773 Free PMC Article

Comparison of Clinical Features and Treatment Outcome in Benign and Malignant Lacrimal Sac Tumors.

Kuo CY, Tsai CC, Kao SC, Hsu WM, Jui-Ling Liu C
Biomed Res Int 2020;2020:3545839. Epub 2020 Jan 31 doi: 10.1155/2020/3545839. PMID: 32090081 Free PMC Article

Epithelial tumors of the lacrimal gland: clinico-pathologic correlation and management.

Riedel KG, Markl A, Hasenfratz G, Kampik A, Stefani FH, Lund OE
Neurosurg Rev 1990;13(4):289-98. doi: 10.1007/BF00346367. PMID: 2177857

See all (6)

Recent clinical studies

Etiology

Blood-stained tears-a red flag for malignancy?

Kaushik M, Juniat V, Ezra DG, Verity DH, Uddin J, Timlin H
Eye (Lond) 2023 Jun;37(8):1711-1716. Epub 2022 Sep 10 doi: 10.1038/s41433-022-02224-x. PMID: 36088421 Free PMC Article

A single-institution review of lacrimal gland biopsies between 1962 and 2017.

Choi CJ, Tran AQ, Anagnostopoulos AG, Zhou HW, Tse DT, Dubovy SR
Orbit 2023 Apr;42(2):148-156. Epub 2022 Mar 17 doi: 10.1080/01676830.2022.2052113. PMID: 35298320

Carcinomas of the lacrimal drainage system.

Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Overview of benign and malignant lacrimal gland tumors.

Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745

See all (78)

Diagnosis

Carcinomas of the lacrimal drainage system.

Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675

Dacryops - A review.

Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Overview of benign and malignant lacrimal gland tumors.

Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745

An Update on Tumors of the Lacrimal Gland.

Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

See all (154)

Therapy

Outcomes of lacrimal punctal tumors treated with a superpulse CO(2) laser.

Chen C, Lee YK, Lai CC
Lasers Med Sci 2022 Jun;37(4):2287-2291. Epub 2022 Jan 6 doi: 10.1007/s10103-021-03500-0. PMID: 34993707

Angioleiomyoma of the nasolacrimal duct: case report and literature review.

Azhdam AM, Wang Y, Douglas RS, Chang EE, Wu AW
Orbit 2022 Dec;41(6):783-785. Epub 2021 May 30 doi: 10.1080/01676830.2021.1933080. PMID: 34057005

Case Series of Laser Therapy of Eyelid Peripunctal Benign Tumor.

Song N, Tong H, Ma J, Zhang J
Photobiomodul Photomed Laser Surg 2021 Oct;39(10):661-664. Epub 2021 Oct 1 doi: 10.1089/photob.2021.0007. PMID: 34597195

Incidence of neoplasia in patients with unilateral epiphora.

Bewes T, Sacks R, Sacks PL, Chin D, Mrad N, Wilcsek G, Tumuluri K, Harvey R
J Laryngol Otol 2015 Jul;129 Suppl 3:S53-7. doi: 10.1017/S0022215115001504. PMID: 26173845

CORE needle biopsy of orbital tumors.

Yarovoy AA, Bulgakova ES, Shatskikh AV, Uzunyan DG, Kleyankina SS, Golubeva OV
Graefes Arch Clin Exp Ophthalmol 2013 Aug;251(8):2057-61. Epub 2013 Mar 21 doi: 10.1007/s00417-013-2315-6. PMID: 23515750

See all (14)

Prognosis

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Overview of benign and malignant lacrimal gland tumors.

Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745

An Update on Tumors of the Lacrimal Gland.

Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

The nasolabial cyst: a nonodontogenic oral cyst related to nasolacrimal duct epithelium.

Toribio Y, Roehrl MH
Arch Pathol Lab Med 2011 Nov;135(11):1499-503. doi: 10.5858/arpa.2010-0338-RS. PMID: 22032581

Sebaceous carcinoma of the ocular adnexa.

Kass LG, Hornblass A
Surv Ophthalmol 1989 May-Jun;33(6):477-90. doi: 10.1016/0039-6257(89)90049-0. PMID: 2658172

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Clinical prediction guides

Clinicopathological and immunohistochemical behavior of ductal carcinoma of the salivary and lacrimal gland in a Mexican Mestizo population.

Luna-Ortiz K, Dominguez-Malagon H, Corredor-Alonso GE, Reynoso-Noveron N, Herrera-Ponzanelli C, Luna-Peteuil Z, Zacarias-Ramon LC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):327-333. Epub 2021 Mar 24 doi: 10.1007/s00405-021-06757-x. PMID: 33763743

Case Series of Laser Therapy of Eyelid Peripunctal Benign Tumor.

Song N, Tong H, Ma J, Zhang J
Photobiomodul Photomed Laser Surg 2021 Oct;39(10):661-664. Epub 2021 Oct 1 doi: 10.1089/photob.2021.0007. PMID: 34597195

Dacryops - A review.

Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Schneiderian papillomas and carcinomas: a review.

Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954

See all (34)