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Elevated urine pyridinoline level

MedGen UID:
1787449
•Concept ID:
C5539551
•
Finding
Synonym: Elevated urine hydroxylysyl-pyridinoline level
 
HPO: HP:0033385

Definition

An increased amount of pyridinoline in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urine pyridinoline level

Professional guidelines

PubMed

Markers of bone turnover in hyperthyroidism and the effects of treatment.
Garnero P, Vassy V, Bertholin A, Riou JP, Delmas PD
J Clin Endocrinol Metab 1994 Apr;78(4):955-9. doi: 10.1210/jcem.78.4.8157727. PMID: 8157727

Recent clinical studies

Etiology

Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study.
Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ
Transplantation 2001 Jul 15;72(1):83-8. doi: 10.1097/00007890-200107150-00017. PMID: 11468539
Biochemical bone turnover markers in patients with ankylosing spondylitis.
Yilmaz N, Ozaslan J
Clin Rheumatol 2000;19(2):92-8. doi: 10.1007/s100670050024. PMID: 10791618
Changes in bone turnover induced by aerobic and anaerobic exercise in young males.
Woitge HW, Friedmann B, Suttner S, Farahmand I, Müller M, Schmidt-Gayk H, Baertsch P, Ziegler R, Seibel MJ
J Bone Miner Res 1998 Dec;13(12):1797-804. doi: 10.1359/jbmr.1998.13.12.1797. PMID: 9844096
Resistance to bone resorbing effects of PTH in black women.
Cosman F, Morgan DC, Nieves JW, Shen V, Luckey MM, Dempster DW, Lindsay R, Parisien M
J Bone Miner Res 1997 Jun;12(6):958-66. doi: 10.1359/jbmr.1997.12.6.958. PMID: 9169356
Oral 1,25-dihydroxyvitamin D administration in osteoporotic women: effects of estrogen therapy.
Cosman F, Nieves J, Shen V, Lindsay R
J Bone Miner Res 1995 Apr;10(4):594-600. doi: 10.1002/jbmr.5650100412. PMID: 7610930

Diagnosis

High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients.
Mylin AK, Abildgaard N, Johansen JS, Andersen NF, Heickendorff L, Standal T, Gimsing P, Knudsen LM
Eur J Haematol 2008 Apr;80(4):310-7. Epub 2007 Dec 21 doi: 10.1111/j.1600-0609.2007.01027.x. PMID: 18182077
Biochemical markers and skeletal metastases.
Demers LM, Costa L, Lipton A
Cancer 2000 Jun 15;88(12 Suppl):2919-26. doi: 10.1002/1097-0142(20000615)88:12+<2919::aid-cncr7>3.0.co;2-z. PMID: 10898335
Resistance to bone resorbing effects of PTH in black women.
Cosman F, Morgan DC, Nieves JW, Shen V, Luckey MM, Dempster DW, Lindsay R, Parisien M
J Bone Miner Res 1997 Jun;12(6):958-66. doi: 10.1359/jbmr.1997.12.6.958. PMID: 9169356
Markers of bone turnover in hyperthyroidism and the effects of treatment.
Garnero P, Vassy V, Bertholin A, Riou JP, Delmas PD
J Clin Endocrinol Metab 1994 Apr;78(4):955-9. doi: 10.1210/jcem.78.4.8157727. PMID: 8157727
Changes in markers of bone formation and resorption in a bed rest model of weightlessness.
Lueken SA, Arnaud SB, Taylor AK, Baylink DJ
J Bone Miner Res 1993 Dec;8(12):1433-8. doi: 10.1002/jbmr.5650081204. PMID: 8304043

Therapy

Urinary pyridinoline and deoxypyridinoline as bone metabolic markers in predicting therapeutic effects of estrogen and alfacalcidol in women with osteoporosis.
Zhan Z, Yamamoto I, Morita R, Miura H
J Bone Miner Metab 1999;17(2):113-8. doi: 10.1007/s007740050073. PMID: 10340638
Changes in bone turnover induced by aerobic and anaerobic exercise in young males.
Woitge HW, Friedmann B, Suttner S, Farahmand I, Müller M, Schmidt-Gayk H, Baertsch P, Ziegler R, Seibel MJ
J Bone Miner Res 1998 Dec;13(12):1797-804. doi: 10.1359/jbmr.1998.13.12.1797. PMID: 9844096
Urinary pyridinoline and deoxypyridinoline in healthy children and in children with growth hormone deficiency.
Fujimoto S, Kubo T, Tanaka H, Miura M, Seino Y
J Clin Endocrinol Metab 1995 Jun;80(6):1922-8. doi: 10.1210/jcem.80.6.7775642. PMID: 7775642
Markers of bone turnover in hyperthyroidism and the effects of treatment.
Garnero P, Vassy V, Bertholin A, Riou JP, Delmas PD
J Clin Endocrinol Metab 1994 Apr;78(4):955-9. doi: 10.1210/jcem.78.4.8157727. PMID: 8157727
Changes in markers of bone formation and resorption in a bed rest model of weightlessness.
Lueken SA, Arnaud SB, Taylor AK, Baylink DJ
J Bone Miner Res 1993 Dec;8(12):1433-8. doi: 10.1002/jbmr.5650081204. PMID: 8304043

Prognosis

High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients.
Mylin AK, Abildgaard N, Johansen JS, Andersen NF, Heickendorff L, Standal T, Gimsing P, Knudsen LM
Eur J Haematol 2008 Apr;80(4):310-7. Epub 2007 Dec 21 doi: 10.1111/j.1600-0609.2007.01027.x. PMID: 18182077
Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study.
Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ
Transplantation 2001 Jul 15;72(1):83-8. doi: 10.1097/00007890-200107150-00017. PMID: 11468539
Posttransplant bone disease: evidence for a high bone resorption state.
Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M
Transplantation 2000 Dec 27;70(12):1722-8. doi: 10.1097/00007890-200012270-00011. PMID: 11152104
Urinary pyridinoline and deoxypyridinoline as bone metabolic markers in predicting therapeutic effects of estrogen and alfacalcidol in women with osteoporosis.
Zhan Z, Yamamoto I, Morita R, Miura H
J Bone Miner Metab 1999;17(2):113-8. doi: 10.1007/s007740050073. PMID: 10340638
Bone mineral density in children with myelomeningocele.
Quan A, Adams R, Ekmark E, Baum M
Pediatrics 1998 Sep;102(3):E34. doi: 10.1542/peds.102.3.e34. PMID: 9724682

Clinical prediction guides

Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study.
Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ
Transplantation 2001 Jul 15;72(1):83-8. doi: 10.1097/00007890-200107150-00017. PMID: 11468539
Biochemical markers and skeletal metastases.
Demers LM, Costa L, Lipton A
Cancer 2000 Jun 15;88(12 Suppl):2919-26. doi: 10.1002/1097-0142(20000615)88:12+<2919::aid-cncr7>3.0.co;2-z. PMID: 10898335
Biochemical bone turnover markers in patients with ankylosing spondylitis.
Yilmaz N, Ozaslan J
Clin Rheumatol 2000;19(2):92-8. doi: 10.1007/s100670050024. PMID: 10791618
Urinary pyridinoline and deoxypyridinoline in healthy children and in children with growth hormone deficiency.
Fujimoto S, Kubo T, Tanaka H, Miura M, Seino Y
J Clin Endocrinol Metab 1995 Jun;80(6):1922-8. doi: 10.1210/jcem.80.6.7775642. PMID: 7775642
Markers of bone turnover in hyperthyroidism and the effects of treatment.
Garnero P, Vassy V, Bertholin A, Riou JP, Delmas PD
J Clin Endocrinol Metab 1994 Apr;78(4):955-9. doi: 10.1210/jcem.78.4.8157727. PMID: 8157727

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