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Metastatic Primary Malignant Brain Neoplasm

MedGen UID:
1788110
•Concept ID:
C5446614
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites. [from NCI]

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085
Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393

Recent clinical studies

Etiology

Cerebral metastases.
Ganz JC
Prog Brain Res 2022;268(1):229-258. Epub 2022 Jan 13 doi: 10.1016/bs.pbr.2021.10.034. PMID: 35074082
Molecular and cellular mechanisms underlying brain metastasis of breast cancer.
Hosonaga M, Saya H, Arima Y
Cancer Metastasis Rev 2020 Sep;39(3):711-720. doi: 10.1007/s10555-020-09881-y. PMID: 32399646Free PMC Article
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, Cheshier SH
Sci Transl Med 2017 Mar 15;9(381) doi: 10.1126/scitranslmed.aaf2968. PMID: 28298418
Brain tumor rehabilitation.
Vargo M
Am J Phys Med Rehabil 2011 May;90(5 Suppl 1):S50-62. doi: 10.1097/PHM.0b013e31820be31f. PMID: 21765264

Diagnosis

Cerebral metastases.
Ganz JC
Prog Brain Res 2022;268(1):229-258. Epub 2022 Jan 13 doi: 10.1016/bs.pbr.2021.10.034. PMID: 35074082
Brain metastasis.
Boire A, Brastianos PK, Garzia L, Valiente M
Nat Rev Cancer 2020 Jan;20(1):4-11. Epub 2019 Nov 28 doi: 10.1038/s41568-019-0220-y. PMID: 31780784
Brain malignancies: Glioblastoma and brain metastases.
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
Brain metastases: neuroimaging.
Pope WB
Handb Clin Neurol 2018;149:89-112. doi: 10.1016/B978-0-12-811161-1.00007-4. PMID: 29307364Free PMC Article
Brain metastases.
Gállego Pérez-Larraya J, Hildebrand J
Handb Clin Neurol 2014;121:1143-57. doi: 10.1016/B978-0-7020-4088-7.00077-8. PMID: 24365409

Therapy

Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial.
Lin NU, Murthy RK, Abramson V, Anders C, Bachelot T, Bedard PL, Borges V, Cameron D, Carey LA, Chien AJ, Curigliano G, DiGiovanna MP, Gelmon K, Hortobagyi G, Hurvitz SA, Krop I, Loi S, Loibl S, Mueller V, Oliveira M, Paplomata E, Pegram M, Slamon D, Zelnak A, Ramos J, Feng W, Winer E
JAMA Oncol 2023 Feb 1;9(2):197-205. doi: 10.1001/jamaoncol.2022.5610. PMID: 36454580Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.
Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377Free PMC Article
Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.
Takahashi T, Yamanaka T, Seto T, Harada H, Nokihara H, Saka H, Nishio M, Kaneda H, Takayama K, Ishimoto O, Takeda K, Yoshioka H, Tachihara M, Sakai H, Goto K, Yamamoto N
Lancet Oncol 2017 May;18(5):663-671. Epub 2017 Mar 23 doi: 10.1016/S1470-2045(17)30230-9. PMID: 28343976
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial.
Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr
Lancet 2004 May 22;363(9422):1665-72. doi: 10.1016/S0140-6736(04)16250-8. PMID: 15158627

Prognosis

Brain metastases: the role of clinical imaging.
Derks SHAE, van der Veldt AAM, Smits M
Br J Radiol 2022 Feb 1;95(1130):20210944. Epub 2021 Dec 14 doi: 10.1259/bjr.20210944. PMID: 34808072Free PMC Article
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.
Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377Free PMC Article
Brain metastases.
Gállego Pérez-Larraya J, Hildebrand J
Handb Clin Neurol 2014;121:1143-57. doi: 10.1016/B978-0-7020-4088-7.00077-8. PMID: 24365409
Epidemiology of brain metastases.
Nayak L, Lee EQ, Wen PY
Curr Oncol Rep 2012 Feb;14(1):48-54. doi: 10.1007/s11912-011-0203-y. PMID: 22012633
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial.
Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr
Lancet 2004 May 22;363(9422):1665-72. doi: 10.1016/S0140-6736(04)16250-8. PMID: 15158627

Clinical prediction guides

Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation.
Wischnewski V, Maas RR, Aruffo PG, Soukup K, Galletti G, Kornete M, Galland S, Fournier N, Lilja J, Wirapati P, Lourenco J, Scarpa A, Daniel RT, Hottinger AF, Brouland JP, Losurdo A, Voulaz E, Alloisio M, Hegi ME, Lugli E, Joyce JA
Nat Cancer 2023 Jun;4(6):908-924. Epub 2023 May 22 doi: 10.1038/s43018-023-00566-3. PMID: 37217652Free PMC Article
Metabolism in the progression and metastasis of brain tumors.
Tyagi A, Wu SY, Watabe K
Cancer Lett 2022 Jul 28;539:215713. Epub 2022 May 2 doi: 10.1016/j.canlet.2022.215713. PMID: 35513201Free PMC Article
Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment.
Passiglia F, Caglevic C, Giovannetti E, Pinto JA, Manca P, Taverna S, Listì A, Gil-Bazo I, Raez LE, Russo A, Rolfo C
Semin Cancer Biol 2018 Oct;52(Pt 2):259-268. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.015. PMID: 29391205
Brain metastases: neuroimaging.
Pope WB
Handb Clin Neurol 2018;149:89-112. doi: 10.1016/B978-0-12-811161-1.00007-4. PMID: 29307364Free PMC Article
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article

Recent systematic reviews

A Systematic Review Informing the Management of Symptomatic Brain Radiation Necrosis After Stereotactic Radiosurgery and International Stereotactic Radiosurgery Society Recommendations.
Vellayappan B, Lim-Fat MJ, Kotecha R, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan JP, Suh JH, Yomo S, Sahgal A
Int J Radiat Oncol Biol Phys 2024 Jan 1;118(1):14-28. Epub 2023 Jul 22 doi: 10.1016/j.ijrobp.2023.07.015. PMID: 37482137
Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document.
Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward WA
Radiother Oncol 2020 Jul;148:157-166. Epub 2020 Apr 22 doi: 10.1016/j.radonc.2020.04.003. PMID: 32388150

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