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Elevated urine kynurenine level

MedGen UID:
1841944
•Concept ID:
C5826410
•
Finding
Synonym: Kynurenine high in urine
 
HPO: HP:0034461

Definition

An abnormally increased amount of kynurenine in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urine kynurenine level

Recent clinical studies

Etiology

Pteridine and tryptophan pathways in children with type 1 diabetes: Isoxanthopterin as an indicator of endothelial dysfunction.
Özer Y, Cansever MŞ, Turan H, Bayramoğlu E, Bingöl Aydın D, İşat E, Ceyhun E, Zubarioğlu T, Aktuğlu Zeybek AÇ, Kıykım E, Evliyaoğlu O
J Pharm Biomed Anal 2024 Jun 15;243:116072. Epub 2024 Feb 27 doi: 10.1016/j.jpba.2024.116072. PMID: 38437786
Oncometabolites in urine - a new opportunity for detection and prognosis of the clinical progress of verified prostate cancer-a pilot study.
Delkov D, Yoanıdu L, Tomov D, Stoyanova R, Dechev I, Uzunova Y
Turk J Med Sci 2022 Jun;52(3):699-706. Epub 2022 Jun 16 doi: 10.55730/1300-0144.5363. PMID: 36326306Free PMC Article
Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.
Ji J, Song L, Wang J, Yang Z, Yan H, Li T, Yu L, Jian L, Jiang F, Li J, Zheng J, Li K
Environ Int 2021 Aug;153:106524. Epub 2021 Mar 19 doi: 10.1016/j.envint.2021.106524. PMID: 33773143Free PMC Article
Possible changes of New-Generation inflammation markers with occupational lead exposure.
Sipahi H, Girgin G, Palabiyik SS, Tutkun E, Yilmaz OH, Baydar T
J Occup Health 2017 Jul 27;59(4):345-351. Epub 2017 Jun 7 doi: 10.1539/joh.16-0273-OA. PMID: 28592710Free PMC Article
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Dharnidharka VR, Al Khasawneh E, Gupta S, Shuster JJ, Theriaque DW, Shahlaee AH, Garrett TJ
Transplantation 2013 Sep;96(6):567-72. doi: 10.1097/TP.0b013e31829c7cec. PMID: 23823655Free PMC Article

Diagnosis

Pteridine and tryptophan pathways in children with type 1 diabetes: Isoxanthopterin as an indicator of endothelial dysfunction.
Özer Y, Cansever MŞ, Turan H, Bayramoğlu E, Bingöl Aydın D, İşat E, Ceyhun E, Zubarioğlu T, Aktuğlu Zeybek AÇ, Kıykım E, Evliyaoğlu O
J Pharm Biomed Anal 2024 Jun 15;243:116072. Epub 2024 Feb 27 doi: 10.1016/j.jpba.2024.116072. PMID: 38437786
Oncometabolites in urine - a new opportunity for detection and prognosis of the clinical progress of verified prostate cancer-a pilot study.
Delkov D, Yoanıdu L, Tomov D, Stoyanova R, Dechev I, Uzunova Y
Turk J Med Sci 2022 Jun;52(3):699-706. Epub 2022 Jun 16 doi: 10.55730/1300-0144.5363. PMID: 36326306Free PMC Article
α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle.
Cooper AJ, Kuhara T
Metab Brain Dis 2014 Dec;29(4):991-1006. Epub 2013 Nov 14 doi: 10.1007/s11011-013-9444-9. PMID: 24234505Free PMC Article
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Dharnidharka VR, Al Khasawneh E, Gupta S, Shuster JJ, Theriaque DW, Shahlaee AH, Garrett TJ
Transplantation 2013 Sep;96(6):567-72. doi: 10.1097/TP.0b013e31829c7cec. PMID: 23823655Free PMC Article
Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation.
Brandacher G, Cakar F, Winkler C, Schneeberger S, Obrist P, Bösmüller C, Werner-Felmayer G, Werner ER, Bonatti H, Margreiter R, Fuchs D
Kidney Int 2007 Jan;71(1):60-7. Epub 2006 Nov 15 doi: 10.1038/sj.ki.5002023. PMID: 17136028

Therapy

Possible changes of New-Generation inflammation markers with occupational lead exposure.
Sipahi H, Girgin G, Palabiyik SS, Tutkun E, Yilmaz OH, Baydar T
J Occup Health 2017 Jul 27;59(4):345-351. Epub 2017 Jun 7 doi: 10.1539/joh.16-0273-OA. PMID: 28592710Free PMC Article
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Dharnidharka VR, Al Khasawneh E, Gupta S, Shuster JJ, Theriaque DW, Shahlaee AH, Garrett TJ
Transplantation 2013 Sep;96(6):567-72. doi: 10.1097/TP.0b013e31829c7cec. PMID: 23823655Free PMC Article
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP).
Dankers AC, Mutsaers HA, Dijkman HB, van den Heuvel LP, Hoenderop JG, Sweep FC, Russel FG, Masereeuw R
Biochim Biophys Acta 2013 Oct;1832(10):1715-22. Epub 2013 May 9 doi: 10.1016/j.bbadis.2013.05.002. PMID: 23665398
Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation.
Brandacher G, Cakar F, Winkler C, Schneeberger S, Obrist P, Bösmüller C, Werner-Felmayer G, Werner ER, Bonatti H, Margreiter R, Fuchs D
Kidney Int 2007 Jan;71(1):60-7. Epub 2006 Nov 15 doi: 10.1038/sj.ki.5002023. PMID: 17136028
Neurokynurenines--seizures or/and anxiety in children with epilepsy?
Melnikova NV
Adv Exp Med Biol 2003;527:191-5. doi: 10.1007/978-1-4615-0135-0_22. PMID: 15206732

Prognosis

Oncometabolites in urine - a new opportunity for detection and prognosis of the clinical progress of verified prostate cancer-a pilot study.
Delkov D, Yoanıdu L, Tomov D, Stoyanova R, Dechev I, Uzunova Y
Turk J Med Sci 2022 Jun;52(3):699-706. Epub 2022 Jun 16 doi: 10.55730/1300-0144.5363. PMID: 36326306Free PMC Article
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Dharnidharka VR, Al Khasawneh E, Gupta S, Shuster JJ, Theriaque DW, Shahlaee AH, Garrett TJ
Transplantation 2013 Sep;96(6):567-72. doi: 10.1097/TP.0b013e31829c7cec. PMID: 23823655Free PMC Article

Clinical prediction guides

Oncometabolites in urine - a new opportunity for detection and prognosis of the clinical progress of verified prostate cancer-a pilot study.
Delkov D, Yoanıdu L, Tomov D, Stoyanova R, Dechev I, Uzunova Y
Turk J Med Sci 2022 Jun;52(3):699-706. Epub 2022 Jun 16 doi: 10.55730/1300-0144.5363. PMID: 36326306Free PMC Article
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Dharnidharka VR, Al Khasawneh E, Gupta S, Shuster JJ, Theriaque DW, Shahlaee AH, Garrett TJ
Transplantation 2013 Sep;96(6):567-72. doi: 10.1097/TP.0b013e31829c7cec. PMID: 23823655Free PMC Article
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP).
Dankers AC, Mutsaers HA, Dijkman HB, van den Heuvel LP, Hoenderop JG, Sweep FC, Russel FG, Masereeuw R
Biochim Biophys Acta 2013 Oct;1832(10):1715-22. Epub 2013 May 9 doi: 10.1016/j.bbadis.2013.05.002. PMID: 23665398
Neurokynurenines--seizures or/and anxiety in children with epilepsy?
Melnikova NV
Adv Exp Med Biol 2003;527:191-5. doi: 10.1007/978-1-4615-0135-0_22. PMID: 15206732
Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin 2.
Brown RR, Lee CM, Kohler PC, Hank JA, Storer BE, Sondel PM
Cancer Res 1989 Sep 1;49(17):4941-4. PMID: 2788032

Recent systematic reviews

The tryptophan catabolite or kynurenine pathway in autism spectrum disorder; a systematic review and meta-analysis.
Almulla AF, Thipakorn Y, Tunvirachaisakul C, Maes M
Autism Res 2023 Dec;16(12):2302-2315. Epub 2023 Nov 1 doi: 10.1002/aur.3044. PMID: 37909397

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