U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Disorder of manganese transport

MedGen UID:
1843191
•Concept ID:
C5681032
•
Disease or Syndrome
Synonym: disorder of manganese transport
 
Monarch Initiative: MONDO:0017766
Orphanet: ORPHA309851

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of manganese transport

Professional guidelines

PubMed

The Association of Essential Metals with APOE Genotype in Alzheimer's Disease.
Babić Leko M, Jurasović J, Nikolac Perković M, Španić E, Sekovanić A, Orct T, Lukinović Škudar V, Bačić Baronica K, Kiđemet-Piskač S, Vogrinc Ž, Pivac N, Borovečki F, Hof PR, Šimić G
J Alzheimers Dis 2021;82(2):661-672. doi: 10.3233/JAD-210158. PMID: 34057084
Hepatic encephalopathy: from pathophysiology to treatment.
Mas A
Digestion 2006;73 Suppl 1:86-93. Epub 2006 Feb 8 doi: 10.1159/000089783. PMID: 16498256
Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment.
Halliwell B
Drugs Aging 2001;18(9):685-716. doi: 10.2165/00002512-200118090-00004. PMID: 11599635

Recent clinical studies

Etiology

Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP.
Fujishiro H, Kambe T
J Pharmacol Sci 2022 Jan;148(1):125-133. Epub 2021 Nov 2 doi: 10.1016/j.jphs.2021.10.011. PMID: 34924116
Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.
Gurol KC, Aschner M, Smith DR, Mukhopadhyay S
Am J Physiol Gastrointest Liver Physiol 2022 Jan 1;322(1):G79-G92. Epub 2021 Nov 17 doi: 10.1152/ajpgi.00299.2021. PMID: 34786983Free PMC Article
Wilson disease.
Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896
Genetic Disorders of Manganese Metabolism.
Anagianni S, Tuschl K
Curr Neurol Neurosci Rep 2019 May 14;19(6):33. doi: 10.1007/s11910-019-0942-y. PMID: 31089831Free PMC Article
Role of advanced glycation end products in cellular signaling.
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
Redox Biol 2014;2:411-29. Epub 2014 Jan 9 doi: 10.1016/j.redox.2013.12.016. PMID: 24624331Free PMC Article

Diagnosis

The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury.
Mapuskar KA, Pulliam CF, Tomanek-Chalkley A, Rastogi P, Wen H, Dayal S, Griffin BR, Zepeda-Orozco D, Sindler AL, Anderson CM, Beardsley R, Kennedy EP, Spitz DR, Allen BG
Redox Biol 2024 Apr;70:103022. Epub 2024 Jan 1 doi: 10.1016/j.redox.2023.103022. PMID: 38215546Free PMC Article
Wilson disease.
Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896
Genetic Disorders of Manganese Metabolism.
Anagianni S, Tuschl K
Curr Neurol Neurosci Rep 2019 May 14;19(6):33. doi: 10.1007/s11910-019-0942-y. PMID: 31089831Free PMC Article
Disorders of heavy metals.
Woimant F, Trocello JM
Handb Clin Neurol 2014;120:851-64. doi: 10.1016/B978-0-7020-4087-0.00057-7. PMID: 24365357
Manganese homeostasis and transport.
Roth J, Ponzoni S, Aschner M
Met Ions Life Sci 2013;12:169-201. doi: 10.1007/978-94-007-5561-1_6. PMID: 23595673Free PMC Article

Therapy

The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury.
Mapuskar KA, Pulliam CF, Tomanek-Chalkley A, Rastogi P, Wen H, Dayal S, Griffin BR, Zepeda-Orozco D, Sindler AL, Anderson CM, Beardsley R, Kennedy EP, Spitz DR, Allen BG
Redox Biol 2024 Apr;70:103022. Epub 2024 Jan 1 doi: 10.1016/j.redox.2023.103022. PMID: 38215546Free PMC Article
Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP.
Fujishiro H, Kambe T
J Pharmacol Sci 2022 Jan;148(1):125-133. Epub 2021 Nov 2 doi: 10.1016/j.jphs.2021.10.011. PMID: 34924116
Wilson disease.
Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896
Neurotoxicity of Metal Mixtures.
Andrade VM, Aschner M, Marreilha Dos Santos AP
Adv Neurobiol 2017;18:227-265. doi: 10.1007/978-3-319-60189-2_12. PMID: 28889271
Role of advanced glycation end products in cellular signaling.
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
Redox Biol 2014;2:411-29. Epub 2014 Jan 9 doi: 10.1016/j.redox.2013.12.016. PMID: 24624331Free PMC Article

Prognosis

Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese- and cadmium-transporting activity.
Fujishiro H, Miyamoto S, Sumi D, Kambe T, Himeno S
Biochem Biophys Res Commun 2022 Aug 6;616:26-32. Epub 2022 May 20 doi: 10.1016/j.bbrc.2022.05.068. PMID: 35636252
Clinical, molecular and glycophenotype insights in SLC39A8-CDG.
Bonaventura E, Barone R, Sturiale L, Pasquariello R, Alessandrì MG, Pinto AM, Renieri A, Panteghini C, Garavaglia B, Cioni G, Battini R
Orphanet J Rare Dis 2021 Jul 10;16(1):307. doi: 10.1186/s13023-021-01941-y. PMID: 34246313Free PMC Article
Tardive dyskinesia: Who gets it and why.
Frei K
Parkinsonism Relat Disord 2019 Feb;59:151-154. Epub 2018 Nov 15 doi: 10.1016/j.parkreldis.2018.11.017. PMID: 30522959
Manganese enhanced magnetic resonance imaging (MEMRI): a powerful new imaging method to study tinnitus.
Cacace AT, Brozoski T, Berkowitz B, Bauer C, Odintsov B, Bergkvist M, Castracane J, Zhang J, Holt AG
Hear Res 2014 May;311:49-62. Epub 2014 Feb 26 doi: 10.1016/j.heares.2014.02.003. PMID: 24583078
Metallic prions.
Brown DR
Biochem Soc Symp 2004;(71):193-202. doi: 10.1042/bss0710193. PMID: 15777022

Clinical prediction guides

Comparative analysis of the functional properties of human and mouse ferroportin.
Azucenas CR, Ruwe TA, Bonamer JP, Qiao B, Ganz T, Jormakka M, Nemeth E, Mackenzie B
Am J Physiol Cell Physiol 2023 May 1;324(5):C1110-C1118. Epub 2023 Mar 20 doi: 10.1152/ajpcell.00063.2023. PMID: 36939203Free PMC Article
Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.
Gurol KC, Aschner M, Smith DR, Mukhopadhyay S
Am J Physiol Gastrointest Liver Physiol 2022 Jan 1;322(1):G79-G92. Epub 2021 Nov 17 doi: 10.1152/ajpgi.00299.2021. PMID: 34786983Free PMC Article
Tardive dyskinesia: Who gets it and why.
Frei K
Parkinsonism Relat Disord 2019 Feb;59:151-154. Epub 2018 Nov 15 doi: 10.1016/j.parkreldis.2018.11.017. PMID: 30522959
The prion-ZIP connection: From cousins to partners in iron uptake.
Singh N, Asthana A, Baksi S, Desai V, Haldar S, Hari S, Tripathi AK
Prion 2015;9(6):420-8. doi: 10.1080/19336896.2015.1118602. PMID: 26689487Free PMC Article
Soils and geomedicine.
Steinnes E
Environ Geochem Health 2009 Oct;31(5):523-35. doi: 10.1007/s10653-009-9257-2. PMID: 19350398

Recent systematic reviews

Essential Trace Elements in Patients with Dyslipidemia: A Meta-analysis.
Li CP, Song YX, Lin ZJ, Ma ML, He LP
Curr Med Chem 2024;31(23):3604-3623. doi: 10.2174/0929867330666230428161653. PMID: 37132140Free PMC Article
Systematic and state-of the science review of the role of environmental factors in Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease.
Newell ME, Adhikari S, Halden RU
Sci Total Environ 2022 Apr 15;817:152504. Epub 2021 Dec 28 doi: 10.1016/j.scitotenv.2021.152504. PMID: 34971691

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...