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Benign neoplasm of sebaceous gland

MedGen UID:
195772
•Concept ID:
C0684358
•
Neoplastic Process
Synonyms: Benign Neoplasm of Sebaceous Gland; benign neoplasm of sebaceous gland; Benign Neoplasm of the Sebaceous Gland; benign neoplasm of the sebaceous gland; Benign Sebaceous Gland Neoplasm; benign sebaceous gland neoplasm; Benign Sebaceous Gland Tumor; benign sebaceous gland tumor; benign sebaceous gland tumour; Benign Sebaceous Neoplasm; benign sebaceous neoplasm; Benign Sebaceous Skin Neoplasm; benign sebaceous skin neoplasm; Benign Sebaceous Skin Tumor; benign sebaceous skin tumor; benign sebaceous skin tumour; Benign Sebaceous Tumor; benign sebaceous tumor; benign sebaceous tumour; Benign Tumor of Sebaceous Gland; benign tumor of sebaceous gland; Benign Tumor of the Sebaceous Gland; benign tumor of the sebaceous gland; benign tumour of sebaceous gland; benign tumour of the sebaceous gland; sebaceous gland benign neoplasm
SNOMED CT: Benign neoplasm of sebaceous gland (92337009)
 
Monarch Initiative: MONDO:0021490

Definition

An epithelial neoplasm that arises from the sebaceous gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of sebaceous gland

Professional guidelines

PubMed

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Expanded extracolonic tumor spectrum in MUTYH-associated polyposis.
Vogt S, Jones N, Christian D, Engel C, Nielsen M, Kaufmann A, Steinke V, Vasen HF, Propping P, Sampson JR, Hes FJ, Aretz S
Gastroenterology 2009 Dec;137(6):1976-85.e1-10. Epub 2009 Sep 2 doi: 10.1053/j.gastro.2009.08.052. PMID: 19732775

Diagnosis

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
The lowly chalazion.
Kim ES, Afshin EE, Elahi E
Surv Ophthalmol 2023 Jul-Aug;68(4):784-793. Epub 2022 Nov 15 doi: 10.1016/j.survophthal.2022.11.002. PMID: 36395826
Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Androgens in women: Androgen-mediated skin disease and patient evaluation.
Bienenfeld A, Azarchi S, Lo Sicco K, Marchbein S, Shapiro J, Nagler AR
J Am Acad Dermatol 2019 Jun;80(6):1497-1506. Epub 2018 Oct 10 doi: 10.1016/j.jaad.2018.08.062. PMID: 30312644
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886

Therapy

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Sebaceous carcinoma: review of the literature.
Kyllo RL, Brady KL, Hurst EA
Dermatol Surg 2015 Jan;41(1):1-15. doi: 10.1097/DSS.0000000000000152. PMID: 25521100
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016

Prognosis

S1-Guideline Sebaceous Carcinoma.
Utikal J, Nagel P, Müller V, Becker JC, Dippel E, Frisman A, Gschnell M, Griewank K, Hadaschik E, Helbig D, Hillen U, Leiter U, Pföhler C, Krönig L, Ziemer M, Ugurel S
J Dtsch Dermatol Ges 2024 May;22(5):730-747. Epub 2024 Apr 28 doi: 10.1111/ddg.15405. PMID: 38679790
Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
Epithelial-Myoepithelial Carcinoma.
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Expanded extracolonic tumor spectrum in MUTYH-associated polyposis.
Vogt S, Jones N, Christian D, Engel C, Nielsen M, Kaufmann A, Steinke V, Vasen HF, Propping P, Sampson JR, Hes FJ, Aretz S
Gastroenterology 2009 Dec;137(6):1976-85.e1-10. Epub 2009 Sep 2 doi: 10.1053/j.gastro.2009.08.052. PMID: 19732775

Clinical prediction guides

Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Sonographic appearance of sebaceous cysts. Our experience and a review of the literature.
Solivetti FM, Desiderio F, Elia F, Guerrisi A, Cota C, Morrone A
Int J Dermatol 2019 Dec;58(12):1353-1359. Epub 2019 Jun 17 doi: 10.1111/ijd.14515. PMID: 31209860
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.
Roberts ME, Riegert-Johnson DL, Thomas BC, Rumilla KM, Thomas CS, Heckman MG, Purcell JU, Hanson NB, Leppig KA, Lim J, Cappel MA
Genet Med 2014 Sep;16(9):711-6. Epub 2014 Mar 6 doi: 10.1038/gim.2014.19. PMID: 24603434
Expanded extracolonic tumor spectrum in MUTYH-associated polyposis.
Vogt S, Jones N, Christian D, Engel C, Nielsen M, Kaufmann A, Steinke V, Vasen HF, Propping P, Sampson JR, Hes FJ, Aretz S
Gastroenterology 2009 Dec;137(6):1976-85.e1-10. Epub 2009 Sep 2 doi: 10.1053/j.gastro.2009.08.052. PMID: 19732775

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Characterization of sebaceous and non-sebaceous cutaneous manifestations in patients with lynch syndrome: a systematic review.
Aziz S, O'Sullivan H, Heelan K, Alam A, McVeigh TP
Fam Cancer 2023 Apr;22(2):167-175. Epub 2022 Nov 23 doi: 10.1007/s10689-022-00319-8. PMID: 36418753Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Sebaceous Carcinoma of the Eyelid: A Systematic Review and Meta-Analysis.
Desiato VM, Byun YJ, Nguyen SA, Thiers BH, Day TA
Dermatol Surg 2021 Jan 1;47(1):104-110. doi: 10.1097/DSS.0000000000002660. PMID: 33347004
Application of intense pulsed light in the treatment of dermatologic disease: a systematic review.
Wat H, Wu DC, Rao J, Goldman MP
Dermatol Surg 2014 Apr;40(4):359-77. Epub 2014 Feb 4 doi: 10.1111/dsu.12424. PMID: 24495252

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