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Benign epithelial skin neoplasm

MedGen UID:: 83395
•Concept ID:: C0345981
•: Neoplastic Process

Synonyms:	Benign epithelial neoplasm of skin; Benign Epithelial Skin Neoplasm; benign epithelial skin neoplasm; Benign Epithelial Skin Tumor; benign epithelial skin tumor; benign epithelial skin tumour; Benign Skin Epithelium Neoplasm; benign skin epithelium neoplasm; Benign Skin Epithelium Tumor; benign skin epithelium tumor; benign skin epithelium tumour; Benign tumor of surface epithelium; epithelial skin neoplasm, benign
SNOMED CT:	Benign epithelial neoplasm of skin (254658001); Benign tumor of surface epithelium (254658001)

Monarch Initiative:	MONDO:0024666

Definition

An epithelial neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign epithelial skin neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign epithelial neoplasm
        Benign epithelial skin neoplasm
        Acanthoma
        Acantholytic acanthoma
        Clear cell acanthoma
        Epidermolytic acanthoma
        Follicular infundibulum tumor
        Large cell acanthoma
        Lichenoid Actinic Keratosis
        Pilar sheath acanthoma
        Seborrheic keratosis
        Eyelid seborrheic keratosis
        Inverted follicular keratosis
        Melanoacanthoma
        Vulvar seborrheic keratosis
        Warty dyskeratoma
        Benign Germinative Follicular Epithelium Neoplasm
        Melanocytic Matricoma
        Pilomatrixoma
        Trichoepithelioma
        Desmoplastic Trichoepithelioma
        Vulvar trichoepithelioma
        Trichofolliculoma
        Benign neoplasm of sebaceous gland
        Sebaceoma
        Sebaceous adenoma
        Superficial Epithelioma with Sebaceous Differentiation
        Benign neoplasm of sweat gland
        Benign Apocrine Neoplasm
        Apocrine adenoma
        Benign eccrine neoplasm
        Digital Papillary Adenoma
        Eccrine Hidrocystoma
        Eccrine syringofibroadenoma
        Syringoma
        Cylindroma
        Familial cylindromatosis
        Sporadic Cylindroma
        Eccrine mixed tumor of skin
        Eccrine spiradenoma
        Benign eccrine breast spiradenoma
        Hidrocystoma
        Apocrine cystadenoma
        Papillary hidradenoma
        Anal Hidradenoma Papilliferum
        Vulvar Hidradenoma Papilliferum
        Spiradenocylindroma
        Sweat gland adenoma
        Acrospiromas
        Clear cell hidradenoma
        Eccrine acrospiroma
        Poroma
        Syringocystadenoma papilliferum
        Tubular Sweat Gland Adenomas
        Benign Outer Hair Sheath and Infundibulum Neoplasm
        Trichilemmoma
        Classic Type Trichilemmoma
        Desmoplastic Trichilemmoma
        Multiple trichilemmomata
        Single trichilemmoma
        Trichoadenoma
        Plantar wart
        Skin Appendage Adenoma
        Skin Myoepithelioma
        Skin papilloma
        Squamous cell skin papilloma
        Verrucae
        Disseminated cutaneous warts
        Epidermodysplasia verruciformis
        Genital warts
        Anal Condyloma Acuminatum
        Buschke Lowenstein tumor
        Cervical Condyloma Acuminatum
        Condyloma acuminata of vagina
        Condyloma acuminata of vulva
        Condyloma Acuminatum with Dysplasia
        Urethral Condyloma Acuminatum
        Oral Verruca Vulgaris
        Verruca plana

Professional guidelines

PubMed

The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma.

Blount SL, Liu X, McBride JD
Cells 2024 Oct 20;13(20) doi: 10.3390/cells13201740. PMID: 39451258 Free PMC Article

Clinical and histopathological profile of primary caruncular lesions.

Alam MS, Pal SS, Krishnakumar S
Indian J Ophthalmol 2022 Jun;70(6):1975-1981. doi: 10.4103/ijo.IJO_2724_21. PMID: 35647965 Free PMC Article

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.

Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094759. PMID: 33946233 Free PMC Article

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Recent clinical studies

Etiology

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.

Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757

Genital human papillomavirus infections.

Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452

The low-risk papillomaviruses.

Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475

Pathology of eyelid tumors.

Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927 Free PMC Article

Canine neoplasia--introductory paper.

Gamlem H, Nordstoga K, Glattre E
APMIS Suppl 2008;(125):5-18. doi: 10.1111/j.1600-0463.2008.125m2.x. PMID: 19385278

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Diagnosis

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.

Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757

Follicular mucinosis: a review.

Khalil J, Kurban M, Abbas O
Int J Dermatol 2021 Feb;60(2):159-165. Epub 2020 Sep 2 doi: 10.1111/ijd.15165. PMID: 32880923

Genital human papillomavirus infections.

Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452

Noninvasive diagnosis in dermatology.

Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087

Immunohistochemical characteristics of melanoma.

Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

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Therapy

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.

Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757

Genital human papillomavirus infections.

Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452

Aluminium and the human breast.

Darbre PD
Morphologie 2016 Jun;100(329):65-74. Epub 2016 Mar 17 doi: 10.1016/j.morpho.2016.02.001. PMID: 26997127

Dermatologic toxicities to targeted cancer therapy: shared clinical and histologic adverse skin reactions.

Curry JL, Torres-Cabala CA, Kim KB, Tetzlaff MT, Duvic M, Tsai KY, Hong DS, Prieto VG
Int J Dermatol 2014 Mar;53(3):376-84. Epub 2013 Jul 24 doi: 10.1111/ijd.12205. PMID: 23879247

Breast adenomas.

Hertel BF, Zaloudek C, Kempson RL
Cancer 1976 Jun;37(6):2891-905. doi: 10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p. PMID: 949710

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Prognosis

The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma.

Blount SL, Liu X, McBride JD
Cells 2024 Oct 20;13(20) doi: 10.3390/cells13201740. PMID: 39451258 Free PMC Article

Clinical relevance and implications of HPV-induced neoplasia in different anatomical locations.

Prigge ES, von Knebel Doeberitz M, Reuschenbach M
Mutat Res Rev Mutat Res 2017 Apr-Jun;772:51-66. Epub 2016 Jun 22 doi: 10.1016/j.mrrev.2016.06.005. PMID: 28528690

Topics in histopathology of sweat gland and sebaceous neoplasms.

Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

Pleomorphic dermal neoplasms: a review.

Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Immunohistochemical characteristics of melanoma.

Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

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Clinical prediction guides

Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not epithelial, and other perplexing mesenchymal lesions.

Carter CS, Patel RM
Mod Pathol 2020 Jan;33(Suppl 1):66-82. Epub 2019 Nov 4 doi: 10.1038/s41379-019-0387-5. PMID: 31685962

Noninvasive diagnosis in dermatology.

Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087

Syringometaplasia: variants and underlying mechanisms.

Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811

Pleomorphic dermal neoplasms: a review.

Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Benign glandular schwannoma.

Kim YC, Park HJ, Cinn YW, Vandersteen DP
Br J Dermatol 2001 Nov;145(5):834-7. doi: 10.1046/j.1365-2133.2001.04476.x. PMID: 11736913

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Recent systematic reviews

A systematic review of Pilomatrix carcinoma arising from the previous scar site of Pilomatrixoma.

Panda SK, Sahoo PK, Agarwala SK, Houghton TT, Sankar KV, Mohanty P
J Cancer Res Ther 2023 Jul-Sep;19(5):1098-1102. doi: 10.4103/jcrt.jcrt_720_21. PMID: 37787269

Novel approaches for managing aged skin and nonmelanoma skin cancer.

Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451

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Benign epithelial skin neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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