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Benign epithelial skin neoplasm

MedGen UID:
83395
•Concept ID:
C0345981
•
Neoplastic Process
Synonyms: Benign epithelial neoplasm of skin; Benign Epithelial Skin Neoplasm; benign epithelial skin neoplasm; Benign Epithelial Skin Tumor; benign epithelial skin tumor; benign epithelial skin tumour; Benign Skin Epithelium Neoplasm; benign skin epithelium neoplasm; Benign Skin Epithelium Tumor; benign skin epithelium tumor; benign skin epithelium tumour; Benign tumor of surface epithelium; epithelial skin neoplasm, benign
SNOMED CT: Benign epithelial neoplasm of skin (254658001); Benign tumor of surface epithelium (254658001)
 
Monarch Initiative: MONDO:0024666

Definition

An epithelial neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign epithelial skin neoplasm

Professional guidelines

PubMed

Clinical and histopathological profile of primary caruncular lesions.
Alam MS, Pal SS, Krishnakumar S
Indian J Ophthalmol 2022 Jun;70(6):1975-1981. doi: 10.4103/ijo.IJO_2724_21. PMID: 35647965Free PMC Article
Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094759. PMID: 33946233Free PMC Article
RAS mutations in benign epithelial tumors associated with BRAF inhibitor treatment of melanoma.
Hassel JC, Groesser L, Herschberger E, Weichert W, Hafner C
J Invest Dermatol 2015 Feb;135(2):636-639. Epub 2014 Jul 18 doi: 10.1038/jid.2014.360. PMID: 25118623

Recent clinical studies

Etiology

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
The low-risk papillomaviruses.
Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475
Congenital and infantile benign skin lesions affecting the hand and upper extremity, part 2: nonvascular neoplasms.
Willard KJ, Cappel MA, Kozin SH, Abzug JM
J Hand Surg Am 2013 Nov;38(11):2284-92. doi: 10.1016/j.jhsa.2013.04.007. PMID: 24206996
Acral lentiginous nevus.
Han KH, Cho KH
J Dermatol 1998 Jan;25(1):23-7. doi: 10.1111/j.1346-8138.1998.tb02340.x. PMID: 9519605

Diagnosis

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Follicular mucinosis: a review.
Khalil J, Kurban M, Abbas O
Int J Dermatol 2021 Feb;60(2):159-165. Epub 2020 Sep 2 doi: 10.1111/ijd.15165. PMID: 32880923
Giant melanotrichoblastoma.
Kim DW, Lee JH, Kim I
Am J Dermatopathol 2011 May;33(3):e37-40. doi: 10.1097/DAD.0b013e3181dfd120. PMID: 20940620
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807
Sclerosing epithelial hamartoma.
Bernstein G, Roth GJ
J Dermatol Surg Oncol 1978 Jan;4(1):87-90. doi: 10.1111/j.1524-4725.1978.tb00386.x. PMID: 618938

Therapy

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Novel approaches for managing aged skin and nonmelanoma skin cancer.
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
Cutaneous melanoma in solid organ transplant patients.
Russo I, Piaserico S, Belloni-Fortina A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):389-94. PMID: 25068225
Tumour related cutaneous elastophagocytosis.
Sweeney EC, McDermott M
J Clin Pathol 1996 Jan;49(1):81-3. doi: 10.1136/jcp.49.1.81. PMID: 8666693Free PMC Article

Prognosis

Benign cysts and tumors of the paranasal sinuses.
Pierse JE, Stern A
Oral Maxillofac Surg Clin North Am 2012 May;24(2):249-64, ix. Epub 2012 Feb 14 doi: 10.1016/j.coms.2012.01.007. PMID: 22341510
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807
Ulcerating Warthin's tumour.
Stárek I, Tichý T, Skýpalová P, Skálová A
Acta Otolaryngol 2004 Aug;124(6):744-6. doi: 10.1080/00016480410016991. PMID: 15515501
Sebaceous lymphadenocarcinoma of salivary glands.
Croitoru CM, Mooney JE, Luna MA
Ann Diagn Pathol 2003 Aug;7(4):236-9. doi: 10.1016/s1092-9134(03)00052-2. PMID: 12913846
Sector hamartoma of the iris.
Jakobiec FA, Howard GM, Devoe AG
Arch Ophthalmol 1975 Aug;93(8):614-7. doi: 10.1001/archopht.1975.01010020590006. PMID: 1156222

Clinical prediction guides

Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811
Cutaneous intraneural perineurioma: a case report.
Santos-Briz A, Godoy E, Cañueto J, García JL, Mentzel T
Am J Dermatopathol 2013 May;35(3):e45-8. doi: 10.1097/DAD.0b013e31827747d6. PMID: 23221470
Fibrous histiocytomas: histopathologic review of 95 cases.
Canelas MM, Cardoso JC, Andrade PF, Reis JP, Tellechea O
An Bras Dermatol 2010 Mar-Apr;85(2):211-5. doi: 10.1590/s0365-05962010000200011. PMID: 20520936
Tumour related cutaneous elastophagocytosis.
Sweeney EC, McDermott M
J Clin Pathol 1996 Jan;49(1):81-3. doi: 10.1136/jcp.49.1.81. PMID: 8666693Free PMC Article

Recent systematic reviews

A systematic review of Pilomatrix carcinoma arising from the previous scar site of Pilomatrixoma.
Panda SK, Sahoo PK, Agarwala SK, Houghton TT, Sankar KV, Mohanty P
J Cancer Res Ther 2023 Jul-Sep;19(5):1098-1102. doi: 10.4103/jcrt.jcrt_720_21. PMID: 37787269
Novel approaches for managing aged skin and nonmelanoma skin cancer.
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451

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