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Cerebellar astrocytoma

MedGen UID:
196631
Concept ID:
C0740480
Neoplastic Process
Synonyms: astrocytoma (excluding glioblastoma) of cerebellum; Astrocytoma of Cerebellum; astrocytoma of cerebellum; Astrocytoma of the Cerebellum; astrocytoma of the cerebellum; Astrocytoma, Cerebellar; astrocytoma, cerebellar; Cerebellar Astrocytoma; cerebellar astrocytoma; cerebellum astrocytoma; cerebellum astrocytoma (excluding glioblastoma)
 
Monarch Initiative: MONDO:0003165

Definition

Benign and malignant neoplasms of the cerebellum that arise from astrocytes. During childhood the majority are benign pilocytic astrocytomas. In adults both benign and relatively higher grade forms may occur. The most common presenting symptoms are headache, nausea, vomiting, ataxia of gait or limb, paresis, diplopia, and dizziness. Objective signs include weakness, long tract signs, dysmetria, gait ataxia, papilledema, and nystagmus. Surgical resection is often curative. [from NCI]

Professional guidelines

PubMed

Due-Tønnessen BJ, Lundar T, Egge A, Scheie D
J Neurosurg Pediatr 2013 Mar;11(3):245-9. Epub 2012 Dec 14 doi: 10.3171/2012.11.PEDS12265. PMID: 23240848
Chang TC, Kuo HF, Liu PC, Shih KC, Zeisel HJ, Ho LT
Zhonghua Yi Xue Za Zhi (Taipei) 1991 Jan;47(1):7-12. PMID: 1848467
Koza I, Bohunický L, Svancárová L, Mardiak J, Gyárfás J, Cerný V
Neoplasma 1989;36(6):709-18. PMID: 2615874

Recent clinical studies

Etiology

Nouraeinejad A
Graefes Arch Clin Exp Ophthalmol 2023 Dec;261(12):3347-3354. Epub 2023 May 5 doi: 10.1007/s00417-023-06092-3. PMID: 37145335Free PMC Article
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Starowicz-Filip A, Chrobak AA, Kwiatkowski S, Milczarek O, Rajtar-Zembaty AM
Child Neuropsychol 2020 Apr;26(3):388-408. Epub 2019 Aug 27 doi: 10.1080/09297049.2019.1657391. PMID: 31451041
Bull KS, Liossi C, Peacock JL, Yuen HM, Kennedy CR; Children's Cancer and Leukaemia Group (CCLG)
Neuro Oncol 2015 Dec;17(12):1628-36. Epub 2015 Jul 22 doi: 10.1093/neuonc/nov129. PMID: 26203065Free PMC Article
Piscione PJ, Bouffet E, Mabbott DJ, Shams I, Kulkarni AV
Neuro Oncol 2014 Jan;16(1):147-55. Epub 2013 Dec 4 doi: 10.1093/neuonc/not138. PMID: 24305707Free PMC Article

Diagnosis

Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Bonfield CM, Steinbok P
Childs Nerv Syst 2015 Oct;31(10):1677-85. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2719-1. PMID: 26351221
Rasalkar DD, Chu WC, Paunipagar BK, Cheng FW, Li CK
Postgrad Med J 2013 Jan;89(1047):39-46. Epub 2012 Sep 12 doi: 10.1136/postgradmedj-2011-130075. PMID: 22977284
Boop FA, Chadduck WM
Neurosurgery 1991 Nov;29(5):785-7; discussion 788. doi: 10.1097/00006123-199111000-00026. PMID: 1961415

Therapy

Nicolardi L, DeAngelis LM
J Neurooncol 2006 May;78(1):55-7. doi: 10.1007/s11060-005-9053-5. PMID: 16314941
Aarsen FK, Van Dongen HR, Paquier PF, Van Mourik M, Catsman-Berrevoets CE
Neurology 2004 Apr 27;62(8):1311-6. doi: 10.1212/01.wnl.0000120549.77188.36. PMID: 15111667
Babu R, Huang PP, Epstein F, Budzilovich GN
J Neurooncol 1993 Jul;17(1):37-42. doi: 10.1007/BF01054272. PMID: 8120570
Conway PD, Oechler HW, Kun LE, Murray KJ
Cancer 1991 Jun 1;67(11):2772-5. doi: 10.1002/1097-0142(19910601)67:11<2772::aid-cncr2820671110>3.0.co;2-#. PMID: 1851047
Chang TC, Kuo HF, Liu PC, Shih KC, Zeisel HJ, Ho LT
Zhonghua Yi Xue Za Zhi (Taipei) 1991 Jan;47(1):7-12. PMID: 1848467

Prognosis

Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Bonfield CM, Steinbok P
Childs Nerv Syst 2015 Oct;31(10):1677-85. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2719-1. PMID: 26351221
Piscione PJ, Bouffet E, Mabbott DJ, Shams I, Kulkarni AV
Neuro Oncol 2014 Jan;16(1):147-55. Epub 2013 Dec 4 doi: 10.1093/neuonc/not138. PMID: 24305707Free PMC Article
Rashidi M, DaSilva VR, Minagar A, Rutka JT
Curr Neurol Neurosci Rep 2003 May;3(3):200-5. doi: 10.1007/s11910-003-0079-9. PMID: 12691624
Campbell JW, Pollack IF
J Neurooncol 1996 May-Jun;28(2-3):223-31. doi: 10.1007/BF00250201. PMID: 8832464

Clinical prediction guides

Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Starowicz-Filip A, Chrobak AA, Kwiatkowski S, Milczarek O, Rajtar-Zembaty AM
Child Neuropsychol 2020 Apr;26(3):388-408. Epub 2019 Aug 27 doi: 10.1080/09297049.2019.1657391. PMID: 31451041
Bull KS, Liossi C, Peacock JL, Yuen HM, Kennedy CR; Children's Cancer and Leukaemia Group (CCLG)
Neuro Oncol 2015 Dec;17(12):1628-36. Epub 2015 Jul 22 doi: 10.1093/neuonc/nov129. PMID: 26203065Free PMC Article
Piscione PJ, Bouffet E, Mabbott DJ, Shams I, Kulkarni AV
Neuro Oncol 2014 Jan;16(1):147-55. Epub 2013 Dec 4 doi: 10.1093/neuonc/not138. PMID: 24305707Free PMC Article
Boop FA, Chadduck WM
Neurosurgery 1991 Nov;29(5):785-7; discussion 788. doi: 10.1097/00006123-199111000-00026. PMID: 1961415

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