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Unilateral retinoblastoma

MedGen UID:
208929
•Concept ID:
C0854915
•
Neoplastic Process
Synonyms: Unilateral Retinoblastoma; unilateral retinoblastoma
 
Monarch Initiative: MONDO:0003076

Definition

A retinoblastoma that only involves a single eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnilateral retinoblastoma

Professional guidelines

PubMed

Treatment of Nonmetastatic Unilateral Retinoblastoma in Children.
Pérez V, Sampor C, Rey G, Parareda-Salles A, Kopp K, Dabezies AP, Dufort G, Zelter M, López JP, Urbieta M, Alcalde-Ruiz E, Catala-Mora J, Suñol M, Ossandon D, Fandiño AC, Croxatto JO, de Dávila MTG, Reaman G, Ravindranath Y, Chantada GL
JAMA Ophthalmol 2018 Jul 1;136(7):747-752. doi: 10.1001/jamaophthalmol.2018.1501. PMID: 29799944Free PMC Article
Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, Shields JA
Curr Opin Ophthalmol 2014 Sep;25(5):374-85. doi: 10.1097/ICU.0000000000000091. PMID: 25014750
Management and outcome of unilateral retinoblastoma.
Mallipatna AC, Sutherland JE, Gallie BL, Chan H, Héon E
J AAPOS 2009 Dec;13(6):546-50. doi: 10.1016/j.jaapos.2009.09.004. PMID: 20006813

Recent clinical studies

Etiology

Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial.
Wen X, Fan J, Jin M, Jiang H, Li J, Han M, Zhang C, He X, Luo Y, Yang J, Zhou M, Tan J, Yang X, Ji X, Zhang J, Zhao J, Jia R, Fan X
Lancet Child Adolesc Health 2023 Sep;7(9):613-620. Epub 2023 Jul 31 doi: 10.1016/S2352-4642(23)00141-4. PMID: 37536351
Prenatal ambient pesticide exposure and childhood retinoblastoma.
Thompson S, Ritz B, Cockburn M, Heck JE
Int J Hyg Environ Health 2022 Aug;245:114025. Epub 2022 Aug 26 doi: 10.1016/j.ijheh.2022.114025. PMID: 36037576Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Maternal diet during pregnancy and unilateral retinoblastoma.
Lombardi C, Ganguly A, Bunin GR, Azary S, Alfonso V, Ritz B, Heck JE
Cancer Causes Control 2015 Mar;26(3):387-97. Epub 2014 Dec 27 doi: 10.1007/s10552-014-0514-z. PMID: 25542139Free PMC Article
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Fulco EM, Arias JD, Alarcon C, Pellegrini M, Rishi P, Kaliki S, Bianciotto CG, Shields JA
Eye (Lond) 2013 Feb;27(2):253-64. Epub 2012 Sep 21 doi: 10.1038/eye.2012.175. PMID: 22995941Free PMC Article

Diagnosis

Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial.
Wen X, Fan J, Jin M, Jiang H, Li J, Han M, Zhang C, He X, Luo Y, Yang J, Zhou M, Tan J, Yang X, Ji X, Zhang J, Zhao J, Jia R, Fan X
Lancet Child Adolesc Health 2023 Sep;7(9):613-620. Epub 2023 Jul 31 doi: 10.1016/S2352-4642(23)00141-4. PMID: 37536351
The Genetics of Unilateral Retinoblastoma Clarified.
Wagner RS
J Pediatr Ophthalmol Strabismus 2021 Nov-Dec;58(6):344. Epub 2021 Nov 1 doi: 10.3928/01913913-20211012-01. PMID: 34851786
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Fulco EM, Arias JD, Alarcon C, Pellegrini M, Rishi P, Kaliki S, Bianciotto CG, Shields JA
Eye (Lond) 2013 Feb;27(2):253-64. Epub 2012 Sep 21 doi: 10.1038/eye.2012.175. PMID: 22995941Free PMC Article
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703

Therapy

Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial.
Wen X, Fan J, Jin M, Jiang H, Li J, Han M, Zhang C, He X, Luo Y, Yang J, Zhou M, Tan J, Yang X, Ji X, Zhang J, Zhao J, Jia R, Fan X
Lancet Child Adolesc Health 2023 Sep;7(9):613-620. Epub 2023 Jul 31 doi: 10.1016/S2352-4642(23)00141-4. PMID: 37536351
Prenatal ambient pesticide exposure and childhood retinoblastoma.
Thompson S, Ritz B, Cockburn M, Heck JE
Int J Hyg Environ Health 2022 Aug;245:114025. Epub 2022 Aug 26 doi: 10.1016/j.ijheh.2022.114025. PMID: 36037576Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, Shields JA
Curr Opin Ophthalmol 2014 Sep;25(5):374-85. doi: 10.1097/ICU.0000000000000091. PMID: 25014750
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Fulco EM, Arias JD, Alarcon C, Pellegrini M, Rishi P, Kaliki S, Bianciotto CG, Shields JA
Eye (Lond) 2013 Feb;27(2):253-64. Epub 2012 Sep 21 doi: 10.1038/eye.2012.175. PMID: 22995941Free PMC Article

Prognosis

Clinical characteristics, treatment and prognosis of children with unilateral retinoblastoma and intracranial segment of Retrobulbar optic nerve invasion.
Wang YZ, Zhang Y, Huang DS, Shi JT, Ma JM, Li B, Xu XL, Zhou Y, Gu HL
BMC Ophthalmol 2021 Jan 14;21(1):38. doi: 10.1186/s12886-020-01768-4. PMID: 33446150Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Medical radiation exposure and risk of sporadic retinoblastoma.
Shakeel O, Pace N, Chambers TM, Scheurer ME, Ganguly AA, Lupo PJ, Bunin GR
Pediatr Blood Cancer 2020 Nov;67(11):e28633. Epub 2020 Aug 2 doi: 10.1002/pbc.28633. PMID: 32743912
Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma.
Soliman SE, Dimaras H, Souka AA, Ashry MH, Gallie BL
J Fr Ophtalmol 2015 Jun;38(6):550-8. Epub 2015 May 14 doi: 10.1016/j.jfo.2015.03.003. PMID: 25982424
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703

Clinical prediction guides

Presentation pattern and survival rate of retinoblastoma following chemotherapy: a prospective study.
Atima MO, Idakwo U, Komolafe O, Eisuke S, Shintaro N, Balogun EO, Dingwoke EJ, Orugun AJ, Ukumobe KO, Pam JD, Aladiuba A
BMC Pediatr 2023 Oct 28;23(1):538. doi: 10.1186/s12887-023-04347-w. PMID: 37891551Free PMC Article
RB1 germline mutation spectrum and clinical features in patients with unilateral retinoblastomas.
Fang X, Chen J, Wang Y, Zhao M, Zhang X, Yang L, Ni X, Zhao J, Gallie BL
Ophthalmic Genet 2021 Oct;42(5):593-599. Epub 2021 Jun 30 doi: 10.1080/13816810.2021.1946703. PMID: 34190019
Excessive folic acid intake and relation to adverse health outcome.
Selhub J, Rosenberg IH
Biochimie 2016 Jul;126:71-8. Epub 2016 Apr 27 doi: 10.1016/j.biochi.2016.04.010. PMID: 27131640
Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma.
Soliman SE, Dimaras H, Souka AA, Ashry MH, Gallie BL
J Fr Ophtalmol 2015 Jun;38(6):550-8. Epub 2015 May 14 doi: 10.1016/j.jfo.2015.03.003. PMID: 25982424
Maternal diet during pregnancy and unilateral retinoblastoma.
Lombardi C, Ganguly A, Bunin GR, Azary S, Alfonso V, Ritz B, Heck JE
Cancer Causes Control 2015 Mar;26(3):387-97. Epub 2014 Dec 27 doi: 10.1007/s10552-014-0514-z. PMID: 25542139Free PMC Article

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