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Tularemia

MedGen UID:
22520
Concept ID:
C0041351
Disease or Syndrome
Synonyms: Deerfly fever; Francisella tularensis infection; Lemming fever; Ohara disease; Pahvant Valley plague; Rabbit fever; Yatobyo (Japan)
SNOMED CT: Deerfly fever (19265001); Francis' disease (19265001); O'Hara's disease (19265001); Tularemia (19265001); Infection by Francisella tularensis (19265001); Deer fly fever (19265001); Rabbit fever (19265001); Ohara's disease (19265001); Yatobyo (19265001); Pahvant Valley fever (19265001); Pahvant Valley plague (19265001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018077
Orphanet: ORPHA3392

Definition

A rare bacterial infectious disease caused by <i>Francisella tularensis</i> and characterized by six major clinical presentations: ulceroglandular, glandular, oropharyngeal, oculoglandular, pneumonic, or typhoidal, depending on the route of infection. Early flu-like symptoms are common to all forms and are accompanied/followed by either a skin inoculation ulcer with localized lymphadenopathy; isolated lymphadenopathy; chronic pharyngitis with cervical lymphadenopathy; conjunctivitis with localized lymphadenopathy; lung involvement; severe systemic disease with neurological symptoms. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTularemia
Follow this link to review classifications for Tularemia in Orphanet.

Professional guidelines

PubMed

Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Maurin M
Front Cell Infect Microbiol 2014;4:115. Epub 2014 Aug 19 doi: 10.3389/fcimb.2014.00115. PMID: 25191647Free PMC Article
Harik NS
Pediatr Ann 2013 Jul;42(7):288-92. doi: 10.3928/00904481-20130619-13. PMID: 23805970

Recent clinical studies

Therapy

Rathjen NA, Shahbodaghi SD
Am Fam Physician 2021 Oct 1;104(4):376-385. PMID: 34652097
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article
Edson RS, Terrell CL
Mayo Clin Proc 1999 May;74(5):519-28. doi: 10.4065/74.5.519. PMID: 10319086

Prognosis

Eilbert W, Matella A
Emerg Med Clin North Am 2024 May;42(2):287-302. Epub 2024 Feb 29 doi: 10.1016/j.emc.2024.01.004. PMID: 38641392
Faber M, Heuner K, Jacob D, Grunow R
Front Cell Infect Microbiol 2018;8:40. Epub 2018 Feb 16 doi: 10.3389/fcimb.2018.00040. PMID: 29503812Free PMC Article
Asano S
J Clin Exp Hematop 2012;52(1):1-16. doi: 10.3960/jslrt.52.1. PMID: 22706525
Potz-Biedermann C, Schwendemann L, Schröppel K, Sönnichsen K, Schmidt D, Schaller M
J Dtsch Dermatol Ges 2011 Oct;9(10):806-8. Epub 2011 Apr 19 doi: 10.1111/j.1610-0387.2011.07670.x. PMID: 21501382
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294

Clinical prediction guides

Faber M, Heuner K, Jacob D, Grunow R
Front Cell Infect Microbiol 2018;8:40. Epub 2018 Feb 16 doi: 10.3389/fcimb.2018.00040. PMID: 29503812Free PMC Article
Elkins KL, Kurtz SL, De Pascalis R
Expert Rev Vaccines 2016 Sep;15(9):1183-96. Epub 2016 May 3 doi: 10.1586/14760584.2016.1170601. PMID: 27010448
Asano S
J Clin Exp Hematop 2012;52(1):1-16. doi: 10.3960/jslrt.52.1. PMID: 22706525
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article
Goscienski PJ
Pediatr Infect Dis 1983 Jan-Feb;2(1):69-81. doi: 10.1097/00006454-198301000-00018. PMID: 6340080

Recent systematic reviews

Fleck-Derderian S, Davis KM, Winberg J, Nelson CA, Meaney-Delman D
Clin Infect Dis 2024 Jan 31;78(Suppl 1):S47-S54. doi: 10.1093/cid/ciad686. PMID: 38294114
Nelson CA, Winberg J, Bostic TD, Davis KM, Fleck-Derderian S
Clin Infect Dis 2024 Jan 31;78(Suppl 1):S15-S28. doi: 10.1093/cid/ciad736. PMID: 38294108
Baseri N, Meysamie A, Campanile F, Hamidieh AA, Jafarian A
J Hosp Infect 2022 May;123:156-173. Epub 2021 Nov 6 doi: 10.1016/j.jhin.2021.10.020. PMID: 34752801
Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701Free PMC Article
Mohabbati Mobarez A, Bagheri Amiri F, Esmaeili S
PLoS Negl Trop Dis 2017 Apr;11(4):e0005521. Epub 2017 Apr 10 doi: 10.1371/journal.pntd.0005521. PMID: 28394889Free PMC Article

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