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Alterations in Smell or Taste

MedGen UID:
231052
•Concept ID:
C1332239
•
Sign or Symptom

Definition

A change to taste and/or olfactory perception resulting from disease processes or treatment. [from NCI]

Professional guidelines

PubMed

Endoscopic vs microsurgical transsphenoidal surgery for acromegaly: outcomes in a concurrent series of patients using modern criteria for remission.
Starke RM, Raper DM, Payne SC, Vance ML, Oldfield EH, Jane JA Jr
J Clin Endocrinol Metab 2013 Aug;98(8):3190-8. Epub 2013 Jun 4 doi: 10.1210/jc.2013-1036. PMID: 23737543

Recent clinical studies

Etiology

Exposure to the smell and taste of milk to accelerate feeding in preterm infants.
Delgado Paramo L, Bronnert A, Lin L, Bloomfield FH, Muelbert M, Harding JE
Cochrane Database Syst Rev 2024 May 9;5(5):CD013038. doi: 10.1002/14651858.CD013038.pub3. PMID: 38721883Free PMC Article
Evaluating long-term smell or taste dysfunction in mildly symptomatic COVID-19 patients: a 3-year follow-up study.
Boscolo-Rizzo P, Spinato G, Hopkins C, Marzolino R, Cavicchia A, Zucchini S, Borsetto D, Lechien JR, Vaira LA, Tirelli G
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5625-5630. Epub 2023 Sep 16 doi: 10.1007/s00405-023-08227-y. PMID: 37715807
Olfactory Dysfunction in Mental Illness.
Marin C, Alobid I, Fuentes M, López-Chacón M, Mullol J
Curr Allergy Asthma Rep 2023 Mar;23(3):153-164. Epub 2023 Jan 25 doi: 10.1007/s11882-023-01068-z. PMID: 36696016Free PMC Article
Olfactory dysfunction in aging and neurodegenerative diseases.
Dan X, Wechter N, Gray S, Mohanty JG, Croteau DL, Bohr VA
Ageing Res Rev 2021 Sep;70:101416. Epub 2021 Jul 27 doi: 10.1016/j.arr.2021.101416. PMID: 34325072Free PMC Article
Taste and Hypertension in Humans: Targeting Cardiovascular Disease.
Roura E, Foster S, Winklebach A, Navarro M, Thomas W, Campbell K, Stowasser M
Curr Pharm Des 2016;22(15):2290-305. doi: 10.2174/1381612822666160216151545. PMID: 26881437

Diagnosis

Olfactory Dysfunction in Mental Illness.
Marin C, Alobid I, Fuentes M, López-Chacón M, Mullol J
Curr Allergy Asthma Rep 2023 Mar;23(3):153-164. Epub 2023 Jan 25 doi: 10.1007/s11882-023-01068-z. PMID: 36696016Free PMC Article
Olfactory dysfunction in aging and neurodegenerative diseases.
Dan X, Wechter N, Gray S, Mohanty JG, Croteau DL, Bohr VA
Ageing Res Rev 2021 Sep;70:101416. Epub 2021 Jul 27 doi: 10.1016/j.arr.2021.101416. PMID: 34325072Free PMC Article
Taste transduction and channel synapses in taste buds.
Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK
Pflugers Arch 2021 Jan;473(1):3-13. Epub 2020 Sep 16 doi: 10.1007/s00424-020-02464-4. PMID: 32936320Free PMC Article
Chemosensory dysfunction in neurodegenerative diseases.
Doty RL, Hawkes CH
Handb Clin Neurol 2019;164:325-360. doi: 10.1016/B978-0-444-63855-7.00020-4. PMID: 31604557
The orotrigeminal system.
Klein AH
Handb Clin Neurol 2019;164:205-216. doi: 10.1016/B978-0-444-63855-7.00013-7. PMID: 31604548Free PMC Article

Therapy

Exposure to the smell and taste of milk to accelerate feeding in preterm infants.
Delgado Paramo L, Bronnert A, Lin L, Bloomfield FH, Muelbert M, Harding JE
Cochrane Database Syst Rev 2024 May 9;5(5):CD013038. doi: 10.1002/14651858.CD013038.pub3. PMID: 38721883Free PMC Article
Taste and smell disturbances in cancer patients: a scoping review of available treatments.
Sevryugin O, Kasvis P, Vigano M, Vigano A
Support Care Cancer 2021 Jan;29(1):49-66. Epub 2020 Jul 30 doi: 10.1007/s00520-020-05609-4. PMID: 32734392
Insight in taste alterations during treatment with protein kinase inhibitors.
van der Werf A, Rovithi M, Langius JAE, de van der Schueren MAE, Verheul HMW
Eur J Cancer 2017 Nov;86:125-134. Epub 2017 Oct 4 doi: 10.1016/j.ejca.2017.09.006. PMID: 28987769
Sweeteners and sweetness enhancers.
Belloir C, Neiers F, Briand L
Curr Opin Clin Nutr Metab Care 2017 Jul;20(4):279-285. doi: 10.1097/MCO.0000000000000377. PMID: 28399012
Drug-induced taste disorders.
Doty RL, Shah M, Bromley SM
Drug Saf 2008;31(3):199-215. doi: 10.2165/00002018-200831030-00002. PMID: 18302445

Prognosis

Why Taste Is Pharmacology.
Palmer RK
Handb Exp Pharmacol 2022;275:1-31. doi: 10.1007/164_2022_589. PMID: 35461405
Glucagon-like peptide-1, a matter of taste?
Jensterle M, DeVries JH, Battelino T, Battelino S, Yildiz B, Janez A
Rev Endocr Metab Disord 2021 Dec;22(4):763-775. Epub 2020 Oct 29 doi: 10.1007/s11154-020-09609-x. PMID: 33123893
Clinical Role of Extraoral Bitter Taste Receptors.
Jeruzal-Świątecka J, Fendler W, Pietruszewska W
Int J Mol Sci 2020 Jul 21;21(14) doi: 10.3390/ijms21145156. PMID: 32708215Free PMC Article
Psychophysical testing of smell and taste function.
Doty RL
Handb Clin Neurol 2019;164:229-246. doi: 10.1016/B978-0-444-63855-7.00015-0. PMID: 31604550
Taste and Hypertension in Humans: Targeting Cardiovascular Disease.
Roura E, Foster S, Winklebach A, Navarro M, Thomas W, Campbell K, Stowasser M
Curr Pharm Des 2016;22(15):2290-305. doi: 10.2174/1381612822666160216151545. PMID: 26881437

Clinical prediction guides

Temporal patterns in taste sensitivity.
Costanzo A
Nutr Rev 2024 May 10;82(6):831-847. doi: 10.1093/nutrit/nuad097. PMID: 37558243Free PMC Article
Molecular and Cellular Mechanisms of Salt Taste.
Taruno A, Gordon MD
Annu Rev Physiol 2023 Feb 10;85:25-45. Epub 2022 Nov 4 doi: 10.1146/annurev-physiol-031522-075853. PMID: 36332657
Sugars and Sweet Taste: Addictive or Rewarding?
Greenberg D, St Peter JV
Int J Environ Res Public Health 2021 Sep 17;18(18) doi: 10.3390/ijerph18189791. PMID: 34574716Free PMC Article
Taste loss in the elderly: Possible implications for dietary habits.
Sergi G, Bano G, Pizzato S, Veronese N, Manzato E
Crit Rev Food Sci Nutr 2017 Nov 22;57(17):3684-3689. doi: 10.1080/10408398.2016.1160208. PMID: 27129026
Ageing and taste.
Methven L, Allen VJ, Withers CA, Gosney MA
Proc Nutr Soc 2012 Nov;71(4):556-65. Epub 2012 Aug 13 doi: 10.1017/S0029665112000742. PMID: 22883349

Recent systematic reviews

A systematic review of the biological mediators of fat taste and smell.
Jaime-Lara RB, Brooks BE, Vizioli C, Chiles M, Nawal N, Ortiz-Figueroa RSE, Livinski AA, Agarwal K, Colina-Prisco C, Iannarino N, Hilmi A, Tejeda HA, Joseph PV
Physiol Rev 2023 Jan 1;103(1):855-918. Epub 2022 Sep 15 doi: 10.1152/physrev.00061.2021. PMID: 36409650Free PMC Article
Sensory processing and eating behaviours in autism: A systematic review.
Nimbley E, Golds L, Sharpe H, Gillespie-Smith K, Duffy F
Eur Eat Disord Rev 2022 Sep;30(5):538-559. Epub 2022 Jun 23 doi: 10.1002/erv.2920. PMID: 35737818Free PMC Article
Olfactory dysfunction in aging and neurodegenerative diseases.
Dan X, Wechter N, Gray S, Mohanty JG, Croteau DL, Bohr VA
Ageing Res Rev 2021 Sep;70:101416. Epub 2021 Jul 27 doi: 10.1016/j.arr.2021.101416. PMID: 34325072Free PMC Article
Oral manifestations of Diabetes Mellitus. A systematic review.
Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, Viñas M, López-López J
Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e586-e594. doi: 10.4317/medoral.21655. PMID: 28809366Free PMC Article
Bell's palsy.
Holland NJ, Bernstein JM
BMJ Clin Evid 2014 Apr 9;2014 PMID: 24717284Free PMC Article

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