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Ectopic thymus

MedGen UID:
232148
•Concept ID:
C1333375
•
Disease or Syndrome
Synonyms: Ectopic Thymus; ectopic thymus
 
Monarch Initiative: MONDO:0003848

Definition

A condition in which the thymus gland is abnormally located; this can be secondary to failure of descent during fetal development, or failure of involution. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic thymus

Professional guidelines

PubMed

Intrathyroidal ectopic thymus: an important entity in the differential diagnosis of thyroid nodules.
Cimbek EA, Kaya S, Eyüboğlu İ, Dinç H, Karagüzel G
Turk J Pediatr 2022;64(5):909-914. doi: 10.24953/turkjped.2021.4842. PMID: 36305441
Diagnosis and management of Intratyroid Ectopic Thymus.
Gazek N, Dujovne N, Ayarzábal V, Teplisky D, Herzovich V, Felipe L
Andes Pediatr 2021 Jun;92(3):406-410. doi: 10.32641/andespediatr.v92i3.3439. PMID: 34479247
Genotype-phenotype analysis of the branchio-oculo-facial syndrome.
Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE
Am J Med Genet A 2011 Jan;155A(1):22-32. doi: 10.1002/ajmg.a.33783. PMID: 21204207

Recent clinical studies

Etiology

Diagnosis and management of Intratyroid Ectopic Thymus.
Gazek N, Dujovne N, Ayarzábal V, Teplisky D, Herzovich V, Felipe L
Andes Pediatr 2021 Jun;92(3):406-410. doi: 10.32641/andespediatr.v92i3.3439. PMID: 34479247
Intrathyroidal Ectopic Thymus and Sonoelastographic Findings.
Guneylı S, Aygun MS, Taskin OC, Sagtas E, Colakoglu B
Curr Med Imaging 2021;17(10):1209-1215. doi: 10.2174/1573405617666210329095227. PMID: 33781193
Challenges in diagnosing ectopic thymus tissue in children.
Claes L, Dendooven A, van Heerden J
BMJ Case Rep 2019 Sep 17;12(9) doi: 10.1136/bcr-2018-228807. PMID: 31533948Free PMC Article
Diagnosis of intrathyroidal ectopic thymus in thyroid fine needle aspiration samples.
Li W, Dim D, Paulson L, Rivard D
J Clin Pathol 2019 Feb;72(2):145-151. Epub 2018 Nov 1 doi: 10.1136/jclinpath-2018-205424. PMID: 30385479
Cervical bronchogenic cysts: usual and unusual clinical presentations.
Teissier N, Elmaleh-Bergès M, Ferkdadji L, François M, Van den Abbeele T
Arch Otolaryngol Head Neck Surg 2008 Nov;134(11):1165-9. doi: 10.1001/archotol.134.11.1165. PMID: 19015445

Diagnosis

Imaging palpable tumors in pediatrics: Part 2.
Llanos D, de la Pedraja I, Campos L, Armijo J, Ávila LF
Radiologia (Engl Ed) 2023 Jan-Feb;65(1):43-54. doi: 10.1016/j.rxeng.2023.01.001. PMID: 36842785
Intrathyroidal ectopic thymus: A case series.
Fernandes AC, Fitas AL, Soares J, Nunes A, Lopes L
J Paediatr Child Health 2022 Sep;58(9):1666-1668. Epub 2021 Dec 29 doi: 10.1111/jpc.15868. PMID: 34964534
Ectopic Cervical Thymus: A Common, yet Rarely Symptomatic Pediatric Neck Mass.
Rousslang L, Meldrum J, Veronica R, Poutre A, Biega T
Curr Med Imaging 2021;17(4):544-548. doi: 10.2174/1573405616999201027214101. PMID: 33115395
Pharyngeal Ectopic Thymus: A Case Report.
Chen C, Liu BB, Bian PP, Xu BC, Guo YF
Ear Nose Throat J 2021 Sep;100(8):NP354-NP356. Epub 2020 Apr 22 doi: 10.1177/0145561320918434. PMID: 32320300
Cervical ectopic thymus.
Herman TE, Siegel MJ
J Perinatol 2009 Feb;29(2):173-4. doi: 10.1038/jp.2008.89. PMID: 19177048

Therapy

Subglottic ectopic thymus mimicking airway haemangioma.
Konstantinidou S, Butler CR, Hartley B, Frauenfelder C
BMJ Case Rep 2021 May 19;14(5) doi: 10.1136/bcr-2020-241074. PMID: 34011669Free PMC Article
Outcomes after thymectomy in class I myasthenia gravis.
Mineo TC, Ambrogi V
J Thorac Cardiovasc Surg 2013 May;145(5):1319-24. Epub 2013 Jan 11 doi: 10.1016/j.jtcvs.2012.12.053. PMID: 23312978
Active ectopic thymus predicts poor outcome after thymectomy in class III myasthenia gravis.
Ambrogi V, Mineo TC
J Thorac Cardiovasc Surg 2012 Mar;143(3):601-6. Epub 2011 Dec 17 doi: 10.1016/j.jtcvs.2011.04.050. PMID: 22177829
Thoracoscopic direct suture repair of thoracic duct injury after thoracoscopic mediastinal surgery.
Cho DG, Cho KD, Jo MS
Surg Laparosc Endosc Percutan Tech 2007 Feb;17(1):60-1. doi: 10.1097/01.sle.0000213749.38643.f3. PMID: 17318061
Clinical spectrum of myasthenia gravis and problems of management.
Dhamija RM, Venkataraman S, Roy AK, Sanchetee PC, Bhargava AK
J Assoc Physicians India 1991 Feb;39(2):181. PMID: 1885481

Prognosis

Diagnosis and management of Intratyroid Ectopic Thymus.
Gazek N, Dujovne N, Ayarzábal V, Teplisky D, Herzovich V, Felipe L
Andes Pediatr 2021 Jun;92(3):406-410. doi: 10.32641/andespediatr.v92i3.3439. PMID: 34479247
Difficult intubation in a neonate: a diagnostic dilemma.
Mohanty PK, Som TK, Purkait S, Satapathy AK
BMJ Case Rep 2018 Nov 28;11(1) doi: 10.1136/bcr-2018-224769. PMID: 30567083Free PMC Article
Ectopic intrathyroidal thymus accompanied by intrathyroidal parathyroid as a cause of a solitary thyroid nodule in adult.
Kim A, Kang SH, Bae YK
Int J Clin Exp Pathol 2014;7(9):6375-8. Epub 2014 Aug 15 PMID: 25337294Free PMC Article
Unusual spindle cell tumor of thyroid (SETTLE).
Haberal AN, Aydin H, Turan E, Demirhan B
Thyroid 2008 Jan;18(1):85-7. doi: 10.1089/thy.2007.0021. PMID: 17887930
Provocative testing for occult medullary carcinoma of the thyroid: findings in seven children with multiple endocrine neoplasia type IIa.
Graham SM, Genel M, Touloukian RJ, Barwick KW, Gertner JM, Torony C
J Pediatr Surg 1987 Jun;22(6):501-3. doi: 10.1016/s0022-3468(87)80205-1. PMID: 2886576

Clinical prediction guides

Ectopic Cervical Thymus: A Common, yet Rarely Symptomatic Pediatric Neck Mass.
Rousslang L, Meldrum J, Veronica R, Poutre A, Biega T
Curr Med Imaging 2021;17(4):544-548. doi: 10.2174/1573405616999201027214101. PMID: 33115395
Intrathyroidal ectopic thymus tissue: a diagnostic challenge.
Aydin S, Fatihoglu E, Kacar M
Radiol Med 2019 Jun;124(6):505-509. Epub 2019 Feb 2 doi: 10.1007/s11547-019-00987-0. PMID: 30710204
Ectopic intrathyroidal thymus accompanied by intrathyroidal parathyroid as a cause of a solitary thyroid nodule in adult.
Kim A, Kang SH, Bae YK
Int J Clin Exp Pathol 2014;7(9):6375-8. Epub 2014 Aug 15 PMID: 25337294Free PMC Article
Spindle epithelial tumor with thymuslike differentiation in a 2-year-old boy: a case report.
Casco F, Illanes Moreno M, González Cámpora R, Moreno A, Galera Ruiz H
Anal Quant Cytol Histol 2010 Feb;32(1):53-7. PMID: 20701088
Provocative testing for occult medullary carcinoma of the thyroid: findings in seven children with multiple endocrine neoplasia type IIa.
Graham SM, Genel M, Touloukian RJ, Barwick KW, Gertner JM, Torony C
J Pediatr Surg 1987 Jun;22(6):501-3. doi: 10.1016/s0022-3468(87)80205-1. PMID: 2886576

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