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Non-Neoplastic Thymus Disorder

MedGen UID:
235390
•Concept ID:
C1335046
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the thymus. Representative examples include acute thymic involution and thymic hyperplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Thymus Disorder

Professional guidelines

PubMed

The Hematological Differential Diagnosis of Mediastinal Masses.
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
Late-onset myasthenia gravis - CTLA4(low) genotype association and low-for-age thymic output of naïve T cells.
Chuang WY, Ströbel P, Bohlender-Willke AL, Rieckmann P, Nix W, Schalke B, Gold R, Opitz A, Klinker E, Inoue M, Müller-Hermelink HK, Saruhan-Direskeneli G, Bugert P, Willcox N, Marx A
J Autoimmun 2014 Aug;52:122-9. Epub 2013 Dec 24 doi: 10.1016/j.jaut.2013.12.006. PMID: 24373506
Thymectomy in the treatment of myasthenia gravis: report of 247 patients.
Evoli A, Batocchi AP, Provenzano C, Ricci E, Tonali P
J Neurol 1988 May;235(5):272-6. doi: 10.1007/BF00314173. PMID: 3385443

Recent clinical studies

Etiology

Retrospective histopathology audit of thymectomy specimens: A clinicopathological study of 303 cases spanning the non-neoplastic, benign and malignant spectrum.
Bakshi N, Dhawan S, Rao S, Kumar A
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):527-534. doi: 10.4103/ijpm.ijpm_325_21. PMID: 35900478
Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder.
Li GT, Guo SZ, Liu YJ, Yang B
Clin Exp Obstet Gynecol 2014;41(2):174-6. PMID: 24779246
Late-onset myasthenia gravis - CTLA4(low) genotype association and low-for-age thymic output of naïve T cells.
Chuang WY, Ströbel P, Bohlender-Willke AL, Rieckmann P, Nix W, Schalke B, Gold R, Opitz A, Klinker E, Inoue M, Müller-Hermelink HK, Saruhan-Direskeneli G, Bugert P, Willcox N, Marx A
J Autoimmun 2014 Aug;52:122-9. Epub 2013 Dec 24 doi: 10.1016/j.jaut.2013.12.006. PMID: 24373506
The effects of different levels of dietary restriction on non-neoplastic diseases in male Sprague-Dawley rats.
Duffy PH, Lewis SM, Mayhugh MA, Trotter RW, Thorn BT, Feuers RJ, Turturro A
Aging Clin Exp Res 2004 Feb;16(1):68-78. doi: 10.1007/BF03324535. PMID: 15132295
Thymectomy in the treatment of myasthenia gravis: report of 247 patients.
Evoli A, Batocchi AP, Provenzano C, Ricci E, Tonali P
J Neurol 1988 May;235(5):272-6. doi: 10.1007/BF00314173. PMID: 3385443

Diagnosis

Lipocalin-2: Structure, function, distribution and role in metabolic disorders.
Jaberi SA, Cohen A, D'Souza C, Abdulrazzaq YM, Ojha S, Bastaki S, Adeghate EA
Biomed Pharmacother 2021 Oct;142:112002. Epub 2021 Aug 27 doi: 10.1016/j.biopha.2021.112002. PMID: 34463264
The Hematological Differential Diagnosis of Mediastinal Masses.
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Histologic and molecular assessment of human thymus.
Hale LP
Ann Diagn Pathol 2004 Feb;8(1):50-60. doi: 10.1016/j.anndiagpath.2003.11.006. PMID: 15129912
Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?
Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW
Am J Pathol 1997 Feb;150(2):543-62. PMID: 9033270Free PMC Article

Prognosis

Heat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravis.
Thanner J, Bekos C, Veraar C, Janik S, Laggner M, Boehm PM, Schiefer AI, Müllauer L, Klepetko W, Ankersmit HJ, Moser B
Oncoimmunology 2020 May 13;9(1):1756130. doi: 10.1080/2162402X.2020.1756130. PMID: 32923112Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
NOTCH1 intracellular domain immunohistochemistry as a diagnostic tool to distinguish T-lymphoblastic lymphoma from thymoma.
Jegalian AG, Bodo J, Hsi ED
Am J Surg Pathol 2015 Apr;39(4):565-72. doi: 10.1097/PAS.0000000000000358. PMID: 25517959
Thymectomy in the treatment of myasthenia gravis: report of 247 patients.
Evoli A, Batocchi AP, Provenzano C, Ricci E, Tonali P
J Neurol 1988 May;235(5):272-6. doi: 10.1007/BF00314173. PMID: 3385443

Clinical prediction guides

Heat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravis.
Thanner J, Bekos C, Veraar C, Janik S, Laggner M, Boehm PM, Schiefer AI, Müllauer L, Klepetko W, Ankersmit HJ, Moser B
Oncoimmunology 2020 May 13;9(1):1756130. doi: 10.1080/2162402X.2020.1756130. PMID: 32923112Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
NOTCH1 intracellular domain immunohistochemistry as a diagnostic tool to distinguish T-lymphoblastic lymphoma from thymoma.
Jegalian AG, Bodo J, Hsi ED
Am J Surg Pathol 2015 Apr;39(4):565-72. doi: 10.1097/PAS.0000000000000358. PMID: 25517959
Corpuscular thymoma: entity or variant of organotypical thymomas WHO B2/B3?
Laeng RH, Eimoto T, Kuo TT, Zettl A, Marx A, Moschopulos M, Tateyama H, Shimokawa K
Pathol Res Pract 2006;202(10):697-704. Epub 2006 Aug 2 doi: 10.1016/j.prp.2006.06.001. PMID: 16887284
Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?
Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW
Am J Pathol 1997 Feb;150(2):543-62. PMID: 9033270Free PMC Article

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