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Choroid Spindle Cell Type A Melanoma

MedGen UID:
234142
•Concept ID:
C1333028
•
Neoplastic Process
Synonyms: Spindle Cell Type A Melanoma of Choroid; Spindle Cell Type A Melanoma of the Choroid

Definition

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChoroid Spindle Cell Type A Melanoma

Professional guidelines

PubMed

Tumours of the anterior uvea. III. Oxytalan fibres in the differential diagnosis of leiomyoma and malignant melanoma of the iris.
Noor Sunba MS, Rahi AH, Garner A, Alexander RA, Morgan G
Br J Ophthalmol 1980 Nov;64(11):867-74. doi: 10.1136/bjo.64.11.867. PMID: 7426559Free PMC Article
Management of small elevated pigmented choroidal lesions.
Char DH, Hogan MJ
Br J Ophthalmol 1977 Jan;61(1):54-8. doi: 10.1136/bjo.61.1.54. PMID: 836778Free PMC Article

Recent clinical studies

Etiology

Autophagy and vesicular trafficking in human uveal melanoma: A histopathological study.
Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

Diagnosis

Corneal Perforation as a Rare and Late Manifestation of Choroidal Melanoma.
Berger T, Flockerzi F, Löw U, Flockerzi E, Aljundi W, Abdin A, Daas L, Seitz B
Klin Monbl Augenheilkd 2023 Jul;240(7):871-877. Epub 2023 May 24 doi: 10.1055/a-2069-2354. PMID: 37224861
Very late orbital recurrence of choroidal melanoma four decades post enucleation.
Menicacci C, Al-Jamal RT, De Francesco S, Barchitta M, Girolamo M, Di Maggio A, Hadjistilianou T
Eur J Ophthalmol 2022 Jul;32(4):NP88-NP93. Epub 2021 Mar 11 doi: 10.1177/11206721211001266. PMID: 33706580
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628

Therapy

VITREOUS AND PRERETINAL SEEDING AFTER TRANSVITREAL FINE NEEDLE ASPIRATION BIOPSY OF CHOROIDAL MELANOMA.
Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Retin Cases Brief Rep 2021 Nov 1;15(6):713-717. doi: 10.1097/ICB.0000000000000905. PMID: 31403972
Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Optic nerve invasion of uveal melanoma.
Lindegaard J, Isager P, Prause JU, Heegaard S
APMIS 2007 Jan;115(1):1-16. doi: 10.1111/j.1600-0463.2007.apm_527.x. PMID: 17223846
Cell proliferation activity in posterior uveal melanoma after Ru-106 brachytherapy: an EORTC ocular oncology group study.
Pe'er J, Stefani FH, Seregard S, Kivela T, Lommatzsch P, Prause JU, Sobottka B, Damato B, Chowers I
Br J Ophthalmol 2001 Oct;85(10):1208-12. doi: 10.1136/bjo.85.10.1208. PMID: 11567966Free PMC Article
Histopathologic characteristics of uveal melanomas in eyes enucleated from the Collaborative Ocular Melanoma Study. COMS report no. 6.
Am J Ophthalmol 1998 Jun;125(6):745-66. doi: 10.1016/s0002-9394(98)00040-3. PMID: 9645714

Prognosis

Corneal Perforation as a Rare and Late Manifestation of Choroidal Melanoma.
Berger T, Flockerzi F, Löw U, Flockerzi E, Aljundi W, Abdin A, Daas L, Seitz B
Klin Monbl Augenheilkd 2023 Jul;240(7):871-877. Epub 2023 May 24 doi: 10.1055/a-2069-2354. PMID: 37224861
The Expression of Connexin 37, 40, 43, 45 and Pannexin 1 in the Early Human Retina and Choroid Development and Tumorigenesis.
Žužul M, Lozić M, Filipović N, Čanović S, Didović Pavičić A, Petričević J, Kunac N, Šoljić V, Saraga-Babić M, Konjevoda S, Vukojevic K
Int J Mol Sci 2022 May 25;23(11) doi: 10.3390/ijms23115918. PMID: 35682601Free PMC Article
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098

Clinical prediction guides

Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

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