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Choroidal melanoma

MedGen UID:: 138064
•Concept ID:: C0346388
•: Neoplastic Process

Synonyms:	Choroid Malignant Melanoma; choroid malignant melanoma; Choroid Melanoma; choroid melanoma; Choroidal Melanoma; choroidal melanoma; malignant choroid melanoma; Malignant melanoma of choroid; Malignant Melanoma of Choroid; malignant melanoma of choroid; Malignant Melanoma of the Choroid; malignant melanoma of the choroid; melanoma (disease) of optic choroid; Melanoma of Choroid; melanoma of choroid; Melanoma of the Choroid; melanoma of the choroid; optic choroid melanoma; optic choroid melanoma (disease)
SNOMED CT:	Malignant melanoma of choroid (255021005)

HPO:	HP:0012054
Monarch Initiative:	MONDO:0003878

Definition

Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChoroidal melanoma

Disorder by Site
- Disorder of orbital region
  - Uveal disorder
    - Choroid Disorder
      - Choroid neoplasm
        Choroid cancer
        Choroidal melanoma
        Choroid epithelioid cell melanoma
        Choroid mixed cell melanoma
        Choroid necrotic melanoma
        Choroid spindle cell melanoma
        Choroid Spindle Cell Type A Melanoma
        Choroid Spindle Cell Type B Melanoma
        Intermediate cell type choroid melanoma
        Metastatic Choroid Melanoma

Professional guidelines

PubMed

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.

Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828 Free PMC Article

Laser treatment for choroidal melanoma: Current concepts.

Maheshwari A, Finger PT
Surv Ophthalmol 2023 Mar-Apr;68(2):211-224. Epub 2022 May 27 doi: 10.1016/j.survophthal.2022.05.002. PMID: 35644256

Uveal melanoma: From diagnosis to treatment and the science in between.

Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400 Free PMC Article

See all (109)

Recent clinical studies

Etiology

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.

Updates in imaging in ocular oncology.

Davila JR, Mruthyunjaya P
F1000Res 2019;8 Epub 2019 Oct 1 doi: 10.12688/f1000research.19979.1. PMID: 31602297 Free PMC Article

Choroidal melanoma and pregnancy.

Lemaître S, Lévy-Gabriel C, Desjardins L, Plancher C, Asselain B, Vincent-Salomon A, Lumbroso-Le Rouic L, Dendale R, Rouzier R, Delacroix S, Cassoux N
Acta Ophthalmol 2016 Nov;94(7):e652-e660. Epub 2016 Mar 24 doi: 10.1111/aos.12984. PMID: 27009598

Uveal melanoma: From diagnosis to treatment and the science in between.

Ocular phototherapy.

Singh AD
Eye (Lond) 2013 Feb;27(2):190-8. Epub 2012 Dec 14 doi: 10.1038/eye.2012.258. PMID: 23238445 Free PMC Article

See all (666)

Diagnosis

Small Choroidal Melanoma Associated with Choroidal Neovascularization.

Nemet A, Zloto O, Segev O, Didi Fabian I, Moroz I, Vishnevskia-Dai V
Isr Med Assoc J 2023 Jun;25(6):443-444. PMID: 37381942

Cancers of the eye.

Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109

Choroidal melanoma and pregnancy.

Ocular melanoma.

Grin-Jorgensen C, Berke A, Grin M
Dermatol Clin 1992 Oct;10(4):663-8. PMID: 1395150

Choroidal osteoma.

Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

See all (765)

Therapy

Photodynamic therapy for choroidal melanoma: What is the response rate?

Yordi S, Soto H, Bowen RC, Singh AD
Surv Ophthalmol 2021 Jul-Aug;66(4):552-559. Epub 2021 Jan 2 doi: 10.1016/j.survophthal.2020.09.006. PMID: 33400941

VITREOUS SEEDING OF CHOROIDAL MELANOMA.

Raval V, Bowen RC, Soto H, Biscotti C, Yeaney G, Sears J, Singh A
Retina 2021 Apr 1;41(4):890-894. doi: 10.1097/IAE.0000000000002989. PMID: 33009220

Statins in ophthalmology.

Ooi KG, Khoo P, Vaclavik V, Watson SL
Surv Ophthalmol 2019 May-Jun;64(3):401-432. Epub 2019 Jan 28 doi: 10.1016/j.survophthal.2019.01.013. PMID: 30703407

Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma.

Vasalaki M, Fabian ID, Reddy MA, Cohen VM, Sagoo MS
Br Med Bull 2017 Jan 1;121(1):107-119. doi: 10.1093/bmb/ldw053. PMID: 28069617

Photodynamic therapy in treatment of cutaneous and choroidal melanoma.

Kawczyk-Krupka A, Bugaj AM, Latos W, Zaremba K, Sieroń A
Photodiagnosis Photodyn Ther 2013 Dec;10(4):503-9. Epub 2013 Jun 17 doi: 10.1016/j.pdpdt.2013.05.006. PMID: 24284103

See all (512)

Prognosis

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.

Uveal melanoma: In the era of new treatments.

Wespiser M, Neidhardt E, Negrier S
Cancer Treat Rev 2023 Sep;119:102599. Epub 2023 Jul 7 doi: 10.1016/j.ctrv.2023.102599. PMID: 37473516

Choroidal melanoma and pregnancy.

Ocular melanoma.

Grin-Jorgensen C, Berke A, Grin M
Dermatol Clin 1992 Oct;10(4):663-8. PMID: 1395150

Choroidal osteoma.

Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

See all (532)

Clinical prediction guides

Presumed incipient choroidal melanoma: proposed diagnostic criteria and management.

Jouhi S, Al-Jamal RT, Täll M, Eskelin S, Kivelä TT
Br J Ophthalmol 2023 Mar;107(3):412-417. Epub 2021 Oct 19 doi: 10.1136/bjophthalmol-2020-318658. PMID: 34666992

Photodynamic therapy for choroidal melanoma: What is the response rate?

Yordi S, Soto H, Bowen RC, Singh AD
Surv Ophthalmol 2021 Jul-Aug;66(4):552-559. Epub 2021 Jan 2 doi: 10.1016/j.survophthal.2020.09.006. PMID: 33400941

VITREOUS SEEDING OF CHOROIDAL MELANOMA.

Raval V, Bowen RC, Soto H, Biscotti C, Yeaney G, Sears J, Singh A
Retina 2021 Apr 1;41(4):890-894. doi: 10.1097/IAE.0000000000002989. PMID: 33009220

Cancers of the eye.

Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109

Circumscribed choroidal hemangioma.

Mashayekhi A, Shields CL
Curr Opin Ophthalmol 2003 Jun;14(3):142-9. doi: 10.1097/00055735-200306000-00006. PMID: 12777933

See all (407)

Recent systematic reviews

Vitreoretinal Surgery in the Prevention and Treatment of Toxic Tumour Syndrome in Uveal Melanoma: A Systematic Review.

Romano MR, Catania F, Confalonieri F, Zollet P, Allegrini D, Sergenti J, Lanza FB, Ferrara M, Angi M
Int J Mol Sci 2021 Sep 17;22(18) doi: 10.3390/ijms221810066. PMID: 34576231 Free PMC Article

Updated Systematic Review and Clinical Spectrum of Peripheral Exudative Hemorrhagic Chorioretinopathy.

Badawi AH, Semidey VA, Magliyah M, Al-Dhibi H
Middle East Afr J Ophthalmol 2020 Jan-Mar;27(1):4-9. Epub 2020 Apr 29 doi: 10.4103/meajo.MEAJO_85_20. PMID: 32549717 Free PMC Article

Estimating the risk of malignant transformation of a choroidal nevus.

Singh AD, Kalyani P, Topham A
Ophthalmology 2005 Oct;112(10):1784-9. doi: 10.1016/j.ophtha.2005.06.011. PMID: 16154197

See all (3)

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Choroidal melanoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Practice guidelines

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