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Ciliary body mixed cell melanoma

MedGen UID:
234150
•Concept ID:
C1333051
•
Neoplastic Process
Synonyms: Ciliary Body Mixed Cell Melanoma; ciliary body mixed cell melanoma; ciliary body mixed cell uveal melanoma; mixed cell uveal melanoma of ciliary body
 
Monarch Initiative: MONDO:0003911

Definition

A melanoma arising from the ciliary body. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCiliary body mixed cell melanoma

Professional guidelines

PubMed

Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article

Recent clinical studies

Etiology

Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

Diagnosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Survival from uveal melanoma in Western Australia 1981-2005.
Chew AL, Spilsbury K, Isaacs TW
Clin Exp Ophthalmol 2015 Jul;43(5):422-8. Epub 2015 Feb 12 doi: 10.1111/ceo.12490. PMID: 25556534
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Neoadjuvant intravitreal ranibizumab treatment in high-risk ocular melanoma patients: a two-stage single-centre phase II single-arm study.
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
Survival from uveal melanoma in Western Australia 1981-2005.
Chew AL, Spilsbury K, Isaacs TW
Clin Exp Ophthalmol 2015 Jul;43(5):422-8. Epub 2015 Feb 12 doi: 10.1111/ceo.12490. PMID: 25556534
The value of nucleolar organizer regions in uveal melanoma. The Collaborative Ocular Melanoma Study Group.
Marcus DM, Minkovitz JB, Wardwell SD, Albert DM
Am J Ophthalmol 1990 Nov 15;110(5):527-34. doi: 10.1016/s0002-9394(14)77877-8. PMID: 1700611
Trends in incidence of ocular malignant melanoma in Denmark 1943-1982.
Osterlind A
Int J Cancer 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206. PMID: 3610385

Prognosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article

Clinical prediction guides

Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Survival from uveal melanoma in Western Australia 1981-2005.
Chew AL, Spilsbury K, Isaacs TW
Clin Exp Ophthalmol 2015 Jul;43(5):422-8. Epub 2015 Feb 12 doi: 10.1111/ceo.12490. PMID: 25556534
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

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