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Large cell acanthoma

MedGen UID:
235249
•Concept ID:
C1334362
•
Neoplastic Process
Synonyms: Large Cell Acanthoma; large cell acanthoma
SNOMED CT: Large cell acanthoma (733894009); Large cell acanthoma (1295377001)
 
Monarch Initiative: MONDO:0002961

Definition

A benign, well-circumscribed skin squamous lesion characterized by the presence of enlarged keratinocytes with nuclei twice the normal size. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge cell acanthoma

Recent clinical studies

Etiology

Dermoscopic findings and histopathological correlation in large cell acanthoma.
Jung JH, Jeong SM, Kwon DI, Seong SH, Jang JY, Kim JH, Park JB, Suh KS, Jang MS
Australas J Dermatol 2022 Nov;63(4):e340-e344. Epub 2022 Aug 25 doi: 10.1111/ajd.13912. PMID: 36005944
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma.
Jakobiec FA, Mendoza PR, Colby KA
Am J Ophthalmol 2013 Oct;156(4):830-46. Epub 2013 Jun 17 doi: 10.1016/j.ajo.2013.05.005. PMID: 23786782
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry.
Argenyi ZB, Huston BM, Argenyi EE, Maillet MW, Hurt MA
Am J Dermatopathol 1994 Apr;16(2):140-4. doi: 10.1097/00000372-199404000-00006. PMID: 8030765

Diagnosis

Dermoscopic findings and histopathological correlation in large cell acanthoma.
Jung JH, Jeong SM, Kwon DI, Seong SH, Jang JY, Kim JH, Park JB, Suh KS, Jang MS
Australas J Dermatol 2022 Nov;63(4):e340-e344. Epub 2022 Aug 25 doi: 10.1111/ajd.13912. PMID: 36005944
Large cell acanthoma.
Mehregan DR, Hamzavi F, Brown K
Int J Dermatol 2003 Jan;42(1):36-9. doi: 10.1046/j.1365-4362.2003.01587.x. PMID: 12581141
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry.
Argenyi ZB, Huston BM, Argenyi EE, Maillet MW, Hurt MA
Am J Dermatopathol 1994 Apr;16(2):140-4. doi: 10.1097/00000372-199404000-00006. PMID: 8030765
Large-cell acanthoma is a solar lentigo.
Roewert HJ, Ackerman AB
Am J Dermatopathol 1992 Apr;14(2):122-32. doi: 10.1097/00000372-199204000-00006. PMID: 1533104
Large cell acanthoma. One of the actinic keratoses.
Rahbari H, Pinkus H
Arch Dermatol 1978 Jan;114(1):49-52. doi: 10.1001/archderm.114.1.49. PMID: 619783

Therapy

Large-cell acanthoma.
Weinstock MA
Am J Dermatopathol 1992 Apr;14(2):133-4; discussion 135. doi: 10.1097/00000372-199204000-00007. PMID: 1566973
Large-cell acanthoma is a solar lentigo.
Roewert HJ, Ackerman AB
Am J Dermatopathol 1992 Apr;14(2):122-32. doi: 10.1097/00000372-199204000-00006. PMID: 1533104
Large-cell acanthoma. A distinctive keratosis.
Rabinowitz AD, Inghirami G
Am J Dermatopathol 1992 Apr;14(2):136-8; discussion 139. PMID: 1348913
Multiple large cell acanthomas.
Rabinowitz AD
J Am Acad Dermatol 1983 Jun;8(6):840-5. doi: 10.1016/s0190-9622(83)80014-0. PMID: 6863647

Clinical prediction guides

Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry.
Argenyi ZB, Huston BM, Argenyi EE, Maillet MW, Hurt MA
Am J Dermatopathol 1994 Apr;16(2):140-4. doi: 10.1097/00000372-199404000-00006. PMID: 8030765
Achromic verrucous large cell acanthoma.
Ambrojo P, Aguilar A, Requena L, Sánchez Yus E
J Cutan Pathol 1990 Jun;17(3):182-4. doi: 10.1111/j.1600-0560.1990.tb00079.x. PMID: 2373780

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