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Solid pseudopapillary carcinoma of pancreas

MedGen UID:
236832
Concept ID:
C1336029
Neoplastic Process
Synonyms: Pancreatic solid pseudopapillary carcinoma; pancreatic solid pseudopapillary carcinoma; solid pseudopapillary carcinoma of pancreas; Solid Pseudopapillary Carcinoma of the Pancreas; solid pseudopapillary carcinoma of the pancreas; Solid pseudopapillary neoplasm of the pancreas
SNOMED CT: Pancreatic solid pseudopapillary carcinoma (782697005); Solid pseudopapillary carcinoma of pancreas (782697005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018525
Orphanet: ORPHA424065

Definition

A rare carcinoma of the pancreas characterized by a variable combination of nonspecific signs and symptoms, such as abdominal pain, jaundice, abdominal fullness, anorexia, nausea, vomiting, and weight loss. One-third of the patients are asymptomatic. The tumor has low malignant potential, but can invade locally. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolid pseudopapillary carcinoma of pancreas

Professional guidelines

PubMed

Kim HS, Jang JY
Arch Pathol Lab Med 2022 Mar 1;146(3):322-329. doi: 10.5858/arpa.2020-0395-RA. PMID: 33503225
Iglesias-Garcia J, de la Iglesia-Garcia D, Olmos-Martinez JM, Lariño-Noia J, Dominguez-Muñoz JE
Minerva Gastroenterol Dietol 2020 Mar;66(1):70-81. Epub 2020 Jan 28 doi: 10.23736/S1121-421X.20.02646-X. PMID: 31994370
Katabathina VS, Rikhtehgar OY, Dasyam AK, Manickam R, Prasad SR
Magn Reson Imaging Clin N Am 2018 Aug;26(3):375-389. Epub 2018 Jun 8 doi: 10.1016/j.mric.2018.03.005. PMID: 30376976

Recent clinical studies

Etiology

Megibow AJ
Gastrointest Endosc Clin N Am 2023 Jul;33(3):519-531. Epub 2023 Apr 24 doi: 10.1016/j.giec.2023.03.008. PMID: 37245933
Liu Q, Dai M, Guo J, Wu H, Wang W, Chen G, Hu Y, Han X, Xu Q, Zhang X, Yang S, Zhang Y, Kleeff J, Liao Q, Wu W, Liang Z, Zhang T, Zhao Y
Ann Surg 2023 Dec 1;278(6):1009-1017. Epub 2023 Apr 10 doi: 10.1097/SLA.0000000000005842. PMID: 37036095
Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Burk KS, Knipp D, Sahani DV
Magn Reson Imaging Clin N Am 2018 Aug;26(3):405-420. doi: 10.1016/j.mric.2018.03.006. PMID: 30376978

Diagnosis

Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Zalatnai A, Kis-Orha V
Pathol Oncol Res 2020 Apr;26(2):641-649. Epub 2019 Jun 17 doi: 10.1007/s12253-019-00671-8. PMID: 31209654Free PMC Article
Stauffer JA, Asbun HJ
Surg Clin North Am 2018 Feb;98(1):169-188. doi: 10.1016/j.suc.2017.09.013. PMID: 29191273
Farrell JJ
Dig Dis Sci 2017 Jul;62(7):1827-1839. Epub 2017 May 20 doi: 10.1007/s10620-017-4571-5. PMID: 28528374
Jun SY, Hong SM
Surg Pathol Clin 2016 Dec;9(4):581-593. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.005. PMID: 27926361

Therapy

Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
Mazzarella G, Muttillo EM, Coletta D, Picardi B, Rossi S, Rossi Del Monte S, Gomes V, Muttillo IA
Hepatobiliary Pancreat Dis Int 2024 Aug;23(4):331-338. Epub 2023 May 14 doi: 10.1016/j.hbpd.2023.05.004. PMID: 37236826
Xie D, Wang Z, Sun B, Qu L, Zeng M, Feng L, Guo M, Wang G, Hao J, Zhou G
Front Med 2023 Oct;17(5):907-923. Epub 2023 Sep 8 doi: 10.1007/s11684-023-1009-7. PMID: 37682378
Gao Y, Guo F, Lu Z, Xi C, Wei J, Jiang K, Miao Y, Wu J, Chen J
World J Surg Oncol 2023 Mar 31;21(1):119. doi: 10.1186/s12957-023-03003-y. PMID: 37004027Free PMC Article
Matsumoto K, Kato H
Dig Endosc 2023 May;35(4):430-442. Epub 2022 Dec 13 doi: 10.1111/den.14468. PMID: 36366955

Prognosis

Kawakubo N, Takemoto J, Irie K, Souzaki R, Maniwa J, Obata S, Yoshimaru K, Nagata K, Miyata J, Matsuura T, Tajiri T
Pediatr Int 2023 Jan-Dec;65(1):e15666. doi: 10.1111/ped.15666. PMID: 37888751
Liu Q, Dai M, Guo J, Wu H, Wang W, Chen G, Hu Y, Han X, Xu Q, Zhang X, Yang S, Zhang Y, Kleeff J, Liao Q, Wu W, Liang Z, Zhang T, Zhao Y
Ann Surg 2023 Dec 1;278(6):1009-1017. Epub 2023 Apr 10 doi: 10.1097/SLA.0000000000005842. PMID: 37036095
Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Allam M, Hidalgo Salinas C, Machairas N, Kostakis ID, Watkins J, Fusai GK
J Gastrointest Cancer 2022 Jun;53(2):460-465. Epub 2021 Apr 20 doi: 10.1007/s12029-021-00638-6. PMID: 33877570
Zalatnai A, Kis-Orha V
Pathol Oncol Res 2020 Apr;26(2):641-649. Epub 2019 Jun 17 doi: 10.1007/s12253-019-00671-8. PMID: 31209654Free PMC Article

Clinical prediction guides

Liu Q, Dai M, Guo J, Wu H, Wang W, Chen G, Hu Y, Han X, Xu Q, Zhang X, Yang S, Zhang Y, Kleeff J, Liao Q, Wu W, Liang Z, Zhang T, Zhao Y
Ann Surg 2023 Dec 1;278(6):1009-1017. Epub 2023 Apr 10 doi: 10.1097/SLA.0000000000005842. PMID: 37036095
Kim HS, Jang JY
Arch Pathol Lab Med 2022 Mar 1;146(3):322-329. doi: 10.5858/arpa.2020-0395-RA. PMID: 33503225
Zalatnai A, Kis-Orha V
Pathol Oncol Res 2020 Apr;26(2):641-649. Epub 2019 Jun 17 doi: 10.1007/s12253-019-00671-8. PMID: 31209654Free PMC Article
Stark A, Donahue TR, Reber HA, Hines OJ
JAMA 2016 May 3;315(17):1882-93. doi: 10.1001/jama.2016.4690. PMID: 27139061
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

Recent systematic reviews

Fleming AM, Hendrick LE, Yakoub D, Abdelhafeez H, Deneve JL, Langham MR Jr, Glazer ES, Davidoff AM, Merchant NB, Dickson PV, Murphy AJ
Ann Surg Oncol 2024 Jan;31(1):475-487. Epub 2023 Sep 28 doi: 10.1245/s10434-023-14343-0. PMID: 37768414
Mazzarella G, Muttillo EM, Coletta D, Picardi B, Rossi S, Rossi Del Monte S, Gomes V, Muttillo IA
Hepatobiliary Pancreat Dis Int 2024 Aug;23(4):331-338. Epub 2023 May 14 doi: 10.1016/j.hbpd.2023.05.004. PMID: 37236826
Hao EIU, Hwang HK, Yoon DS, Lee WJ, Kang CM
Medicine (Baltimore) 2018 Dec;97(49):e13147. doi: 10.1097/MD.0000000000013147. PMID: 30544374Free PMC Article
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394
Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, Ali SZ, Fishman EK, Kamel I, Canto MI, Dal Molin M, Moran RA, Khashab MA, Ahuja N, Goggins M, Hruban RH, Wolfgang CL, Lennon AM
Pancreas 2014 Apr;43(3):331-7. doi: 10.1097/MPA.0000000000000061. PMID: 24622060Free PMC Article

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