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Benign vaginal mixed tumor

MedGen UID:
267350
•Concept ID:
C1511107
•
Neoplastic Process
Synonyms: Benign Vaginal Mixed Tumor; benign vaginal mixed tumor; Vaginal Spindle Cell Epithelioma; vaginal spindle cell epithelioma
 
Monarch Initiative: MONDO:0003903

Definition

A non-metastasizing, well circumscribed neoplasm that arises from the vagina and is characterized by the presence of a predominant benign mesenchymal component and benign glandular or squamous epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign vaginal mixed tumor

Recent clinical studies

Etiology

Imaging in gynecological disease (17): ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors).
Anfelter P, Testa A, Chiappa V, Froyman W, Fruscio R, Guerriero S, Alcazar JL, Mascillini F, Pascual MA, Sibal M, Savelli L, Zannoni GF, Timmerman D, Epstein E
Ultrasound Obstet Gynecol 2020 Aug;56(2):276-284. doi: 10.1002/uog.22002. PMID: 32119168
Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428
Benign mixed tumor of the vagina: case report with expanded immunohistochemical profile.
Murdoch F, Sharma R, Al-Nafussi A
Int J Gynecol Cancer 2003 Jul-Aug;13(4):543-7. doi: 10.1046/j.1525-1438.2003.13309.x. PMID: 12911736
Clinical relevance of benign endometrial cells in postmenopausal women.
Ashfaq R, Sharma S, Dulley T, Saboorian MH, Siddiqui MT, Warner C
Diagn Cytopathol 2001 Oct;25(4):235-8. doi: 10.1002/dc.2045. PMID: 11599107
Papillary squamotransitional cell carcinoma of the cervix: a report of 32 cases.
Koenig C, Turnicky RP, Kankam CF, Tavassoli FA
Am J Surg Pathol 1997 Aug;21(8):915-21. doi: 10.1097/00000478-199708000-00005. PMID: 9255254

Diagnosis

Benign mixed Müllerian (duct) vaginal tumor in a 12-y-old goat.
Hartung S, Schlohsarczyk EK, Jost A, Sickinger M, Köhler K
J Vet Diagn Invest 2022 Mar;34(2):298-301. Epub 2022 Jan 10 doi: 10.1177/10406387211069370. PMID: 35000511Free PMC Article
Adenoid cystic carcinoma cytology: Salivary gland and nonsalivary gland.
Chowsilpa S, An D, Maleki Z
Diagn Cytopathol 2020 Dec;48(12):1282-1289. Epub 2020 Aug 18 doi: 10.1002/dc.24573. PMID: 32809258
Benign mixed tumor of the vagina.
Song Y, Wu SG, Dong SN, Luo F, Liu KP
Eur J Gynaecol Oncol 2017;38(3):465-468. PMID: 29693894
Ultrasound scanning of the pelvis and abdomen for staging of gynecological tumors: a review.
Fischerova D
Ultrasound Obstet Gynecol 2011 Sep;38(3):246-66. doi: 10.1002/uog.10054. PMID: 21898632
Mullerian adenosarcoma of the female genital tract.
McCluggage WG
Adv Anat Pathol 2010 Mar;17(2):122-9. doi: 10.1097/PAP.0b013e3181cfe732. PMID: 20179434

Therapy

Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077
Large endometrial polyp with sarcomatous stromal components following long-term tamoxifen treatment for breast cancer: a case report and review of the literature.
Varras M, Akrivis Ch
Eur J Gynaecol Oncol 2003;24(6):565-8. PMID: 14658606

Prognosis

Adenoid cystic carcinoma cytology: Salivary gland and nonsalivary gland.
Chowsilpa S, An D, Maleki Z
Diagn Cytopathol 2020 Dec;48(12):1282-1289. Epub 2020 Aug 18 doi: 10.1002/dc.24573. PMID: 32809258
Mullerian adenosarcoma of the female genital tract.
McCluggage WG
Adv Anat Pathol 2010 Mar;17(2):122-9. doi: 10.1097/PAP.0b013e3181cfe732. PMID: 20179434
Mixed tumor of the vagina: sonographic and magnetic resonance imaging findings.
Laspas F, Roussakis A, Papadopoulos S, Fanariotis I, Kritikos N, Kehagias D
Ultrasound Obstet Gynecol 2010 May;35(5):617-9. doi: 10.1002/uog.7511. PMID: 20069660
Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428
Benign mixed tumor of the vagina: case report with expanded immunohistochemical profile.
Murdoch F, Sharma R, Al-Nafussi A
Int J Gynecol Cancer 2003 Jul-Aug;13(4):543-7. doi: 10.1046/j.1525-1438.2003.13309.x. PMID: 12911736

Clinical prediction guides

Adenoid cystic carcinoma cytology: Salivary gland and nonsalivary gland.
Chowsilpa S, An D, Maleki Z
Diagn Cytopathol 2020 Dec;48(12):1282-1289. Epub 2020 Aug 18 doi: 10.1002/dc.24573. PMID: 32809258
Imaging in gynecological disease (17): ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors).
Anfelter P, Testa A, Chiappa V, Froyman W, Fruscio R, Guerriero S, Alcazar JL, Mascillini F, Pascual MA, Sibal M, Savelli L, Zannoni GF, Timmerman D, Epstein E
Ultrasound Obstet Gynecol 2020 Aug;56(2):276-284. doi: 10.1002/uog.22002. PMID: 32119168
Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428
Uterine carcinomas simulating microglandular hyperplasia. A report of six cases.
Young RH, Scully RE
Am J Surg Pathol 1992 Nov;16(11):1092-7. doi: 10.1097/00000478-199211000-00008. PMID: 1471729
Müllerian adenosarcoma of the uterine cervix with heterologous elements: a light and electron microscopic study.
Roth LM, Pride GL, Sharma HM
Cancer 1976 Apr;37(4):1725-36. doi: 10.1002/1097-0142(197604)37:4<1725::aid-cncr2820370418>3.0.co;2-1. PMID: 177174

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