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Benign female reproductive system neoplasm

MedGen UID:
152872
•Concept ID:
C0744514
•
Neoplastic Process
Synonyms: Benign Female Reproductive System Neoplasm; benign female reproductive system neoplasm; Benign Female Reproductive System Tumor; benign female reproductive system tumor; benign female reproductive system tumour; Benign Gynecologic Neoplasm; benign gynecologic neoplasm; Benign Gynecologic Tumor; benign gynecologic tumor; benign gynecologic tumour; female reproductive organ benign neoplasm
 
Monarch Initiative: MONDO:0000624

Definition

A neoplasm that arises from the female reproductive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign female reproductive system neoplasm

Professional guidelines

PubMed

Diagnosis and management of uterine fibroids: current trends and future strategies.
Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026
Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.
Yang Q, Ciebiera M, Bariani MV, Ali M, Elkafas H, Boyer TG, Al-Hendy A
Endocr Rev 2022 Jul 13;43(4):678-719. doi: 10.1210/endrev/bnab039. PMID: 34741454Free PMC Article
Uterine Fibroids: Diagnosis and Treatment.
De La Cruz MS, Buchanan EM
Am Fam Physician 2017 Jan 15;95(2):100-107. PMID: 28084714

Recent clinical studies

Etiology

Nerve-sparing in Gynecologic Surgery: A Perspective.
Magrina J, Yang J, Yi J, Wasson M
J Minim Invasive Gynecol 2021 Mar;28(3):475-480. Epub 2020 Jul 20 doi: 10.1016/j.jmig.2020.07.009. PMID: 32702513
Abnormal vaginal bleeding in women with gynaecological malignancies.
Adams T, Denny L
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:134-147. Epub 2016 Oct 26 doi: 10.1016/j.bpobgyn.2016.09.014. PMID: 27856158
Uterine Adenosarcoma: a Review.
Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181
Human papillomavirus-associated diseases.
Grce M, Mravak-Stipetić M
Clin Dermatol 2014 Mar-Apr;32(2):253-8. Epub 2013 Oct 30 doi: 10.1016/j.clindermatol.2013.10.006. PMID: 24559561
Geriatric gynecology.
Perkins KE, King MC
Emerg Med Clin North Am 2012 Nov;30(4):1007-19. doi: 10.1016/j.emc.2012.08.011. PMID: 23137409

Diagnosis

Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Complications in modern hysteroscopic myomectomy.
Ciebiera M, Łoziński T, Wojtyła C, Rawski W, Jakiel G
Ginekol Pol 2018;89(7):398-404. doi: 10.5603/GP.a2018.0068. PMID: 30091451
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Uterine Adenosarcoma: a Review.
Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181
Extracardiac rhabdomyomas.
Willis J, Abdul-Karim FW, di Sant'Agnese PA
Semin Diagn Pathol 1994 Feb;11(1):15-25. PMID: 8202643

Therapy

The Role of Nutrition in Pathogenesis of Uterine Fibroids.
Krzyżanowski J, Paszkowski T, Woźniak S
Nutrients 2023 Dec 1;15(23) doi: 10.3390/nu15234984. PMID: 38068842Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Uterine Fibroids and Diet.
Tinelli A, Vinciguerra M, Malvasi A, Andjić M, Babović I, Sparić R
Int J Environ Res Public Health 2021 Jan 25;18(3) doi: 10.3390/ijerph18031066. PMID: 33504114Free PMC Article
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Uterine fibroid management: from the present to the future.
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article

Prognosis

Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Uterine Adenosarcoma: a Review.
Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181
Global burden of human papillomavirus and related diseases.
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955
The tamoxifen controversy.
Crabbe WW
Oncol Nurs Forum 1996 Jun;23(5):761-6. PMID: 8792346

Clinical prediction guides

Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients.
Minneci PC, Bergus KC, Lutz C, Aldrink J, Bence C, Breech L, Dillon PA, Downard C, Ehrlich PF, Fallat M, Fraser JD, Grabowski J, Helmrath M, Hertweck P, Hewitt G, Hirschl RB, Kabre R, Lal DR, Landman M, Leys C, Mak G, Markel T, Pressey J, Raiji M, Rymeski B, Saito J, Sato TT, St Peter SD, Cooper J, Deans K; Midwest Pediatric Surgery Consortium
JAMA 2023 Oct 3;330(13):1247-1254. doi: 10.1001/jama.2023.17183. PMID: 37787794Free PMC Article
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Imaging of Adnexal Masses.
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study.
Van Calster B, Van Hoorde K, Valentin L, Testa AC, Fischerova D, Van Holsbeke C, Savelli L, Franchi D, Epstein E, Kaijser J, Van Belle V, Czekierdowski A, Guerriero S, Fruscio R, Lanzani C, Scala F, Bourne T, Timmerman D; International Ovarian Tumour Analysis Group
BMJ 2014 Oct 15;349:g5920. doi: 10.1136/bmj.g5920. PMID: 25320247Free PMC Article
Simple ultrasound-based rules for the diagnosis of ovarian cancer.
Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

Recent systematic reviews

Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review.
Terp SK, Stoico MP, Dybkær K, Pedersen IS
Clin Epigenetics 2023 Feb 14;15(1):24. doi: 10.1186/s13148-023-01440-w. PMID: 36788585Free PMC Article
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Surgical treatment of fibroids for subfertility.
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.
Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN, Wentzensen N
JAMA Intern Med 2018 Sep 1;178(9):1210-1222. doi: 10.1001/jamainternmed.2018.2820. PMID: 30083701Free PMC Article

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