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Ciliary body epithelioid cell melanoma

MedGen UID:
272484
•Concept ID:
C1333050
•
Neoplastic Process
Synonyms: Ciliary Body Epithelioid Cell Melanoma; ciliary body epithelioid cell melanoma; Epithelioid Cell Melanoma of Ciliary Body; epithelioid cell melanoma of ciliary body; Epithelioid Cell Melanoma of the Ciliary Body; epithelioid cell melanoma of the ciliary body
 
Monarch Initiative: MONDO:0004086

Definition

A ciliary body melanoma characterized by the presence of malignant large epithelioid melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCiliary body epithelioid cell melanoma

Professional guidelines

PubMed

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article
Update on the management of posterior uveal melanoma.
Zhao DY, Shields CL, Shields JA, Gunduz K
J Ophthalmic Nurs Technol 1998 Mar-Apr;17(2):66-71. PMID: 9677975

Recent clinical studies

Etiology

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article

Diagnosis

Tumor Profiles of Late Presentation Uveal Ring Melanoma With Novel Characteristics - A Case Series.
Lim JZ, Crawford AZ, McGhee CNJ
Invest Ophthalmol Vis Sci 2023 Oct 3;64(13):44. doi: 10.1167/iovs.64.13.44. PMID: 37889509Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Nucleolar size in choroidal and ciliary body melanomas and corresponding hepatic metastases.
Al-Jamal RT, Toivonen P, Kivelä T
Acta Ophthalmol 2010 Jun;88(4):458-62. Epub 2009 Jun 22 doi: 10.1111/j.1755-3768.2009.01556.x. PMID: 19549104
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Recurrence of treated ciliary body melanoma following trabeculectomy.
Tay E, Cree IA, Hungerford J, Franks W
Clin Exp Ophthalmol 2009 Jul;37(5):503-5. doi: 10.1111/j.1442-9071.2009.02069.x. PMID: 19624348
Cell proliferation activity in posterior uveal melanoma after Ru-106 brachytherapy: an EORTC ocular oncology group study.
Pe'er J, Stefani FH, Seregard S, Kivela T, Lommatzsch P, Prause JU, Sobottka B, Damato B, Chowers I
Br J Ophthalmol 2001 Oct;85(10):1208-12. doi: 10.1136/bjo.85.10.1208. PMID: 11567966Free PMC Article
Irradiated uveal melanomas: cytopathologic correlation with prognosis.
Char DH, Kroll SM, Miller T, Castro J, Quivey J
Am J Ophthalmol 1996 Oct;122(4):509-13. doi: 10.1016/s0002-9394(14)72110-5. PMID: 8862047
Trends in incidence of ocular malignant melanoma in Denmark 1943-1982.
Osterlind A
Int J Cancer 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206. PMID: 3610385

Prognosis

Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Pathology of ocular melanomas.
McCartney AC
Br Med Bull 1995 Jul;51(3):678-93. doi: 10.1093/oxfordjournals.bmb.a072986. PMID: 7552088

Clinical prediction guides

Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Nucleolar diameter and microvascular factors as independent predictors of mortality from malignant melanoma of the choroid and ciliary body.
Al-Jamal RT, Mäkitie T, Kivelä T
Invest Ophthalmol Vis Sci 2003 Jun;44(6):2381-9. doi: 10.1167/iovs.02-1215. PMID: 12766034
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Establishment and characterization of primary and metastatic uveal melanoma cell lines.
Luyten GP, Naus NC, Mooy CM, Hagemeijer A, Kan-Mitchell J, Van Drunen E, Vuzevski V, De Jong PT, Luider TM
Int J Cancer 1996 May 3;66(3):380-7. doi: 10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F. PMID: 8621261

Recent systematic reviews

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

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