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Larynx cancer

MedGen UID:
2868
•Concept ID:
C0007107
•
Neoplastic Process
Synonym: Laryngeal cancer
SNOMED CT: CA - Cancer of larynx (363429002); Laryngeal cancer (363429002); Cancer of larynx (363429002); Malignant tumor of larynx (363429002)
 
Monarch Initiative: MONDO:0002352

Definition

A primary or metastatic malignant neoplasm involving the larynx. The majority are carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarynx cancer

Professional guidelines

PubMed

Radiotherapy for laryngeal cancers.
Biau J, Pointreau Y, Blanchard P, Khampan C, Giraud P, Lapeyre M, Maingon P
Cancer Radiother 2022 Feb-Apr;26(1-2):206-212. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.09.004. PMID: 34953705
The Changing Demographics and Treatment of Larynx Cancer.
Han J, Sumer BD
Ann Surg Oncol 2021 Nov;28(12):6927-6928. Epub 2021 Aug 24 doi: 10.1245/s10434-021-10657-z. PMID: 34431018
Transoral and Transcervical Surgical Innovations in the Treatment of Glottic Cancer.
Zeitels SM
Otolaryngol Clin North Am 2015 Aug;48(4):677-85. doi: 10.1016/j.otc.2015.04.012. PMID: 26233792

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Updates on Larynx Cancer: Risk Factors and Oncogenesis.
Liberale C, Soloperto D, Marchioni A, Monzani D, Sacchetto L
Int J Mol Sci 2023 Aug 18;24(16) doi: 10.3390/ijms241612913. PMID: 37629093Free PMC Article
Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Respiratory Tract Cancers Collaborators
Lancet Respir Med 2021 Sep;9(9):1030-1049. Epub 2021 Aug 16 doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511Free PMC Article
Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.
Hayes RB, Ahn J, Fan X, Peters BA, Ma Y, Yang L, Agalliu I, Burk RD, Ganly I, Purdue MP, Freedman ND, Gapstur SM, Pei Z
JAMA Oncol 2018 Mar 1;4(3):358-365. doi: 10.1001/jamaoncol.2017.4777. PMID: 29327043Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Diagnosis

Diagnostic Assessment (Imaging) and Staging of Laryngeal Cancer.
Itamura K, Hsue VB, Barbu AM, Chen MM
Otolaryngol Clin North Am 2023 Apr;56(2):215-231. doi: 10.1016/j.otc.2022.12.006. PMID: 37030936
Trends in Incidence and Mortality of Larynx Cancer in the US.
Divakar P, Davies L
JAMA Otolaryngol Head Neck Surg 2023 Jan 1;149(1):34-41. doi: 10.1001/jamaoto.2022.3636. PMID: 36394832Free PMC Article
Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Advanced larynx cancer.
Strome SE, Weinman EC
Curr Treat Options Oncol 2002 Feb;3(1):11-20. doi: 10.1007/s11864-002-0037-9. PMID: 12057083

Therapy

Updates on Larynx Cancer: Risk Factors and Oncogenesis.
Liberale C, Soloperto D, Marchioni A, Monzani D, Sacchetto L
Int J Mol Sci 2023 Aug 18;24(16) doi: 10.3390/ijms241612913. PMID: 37629093Free PMC Article
Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.
Hayes RB, Ahn J, Fan X, Peters BA, Ma Y, Yang L, Agalliu I, Burk RD, Ganly I, Purdue MP, Freedman ND, Gapstur SM, Pei Z
JAMA Oncol 2018 Mar 1;4(3):358-365. doi: 10.1001/jamaoncol.2017.4777. PMID: 29327043Free PMC Article
Occupation and cancer of the larynx: a systematic review and meta-analysis.
Bayer O, Cámara R, Zeissig SR, Ressing M, Dietz A, Locati LD, Ramroth H, Singer S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):9-20. Epub 2014 Oct 14 doi: 10.1007/s00405-014-3321-y. PMID: 25311307
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article
Larynx preservation.
Lefebvre JL
Curr Opin Oncol 2012 May;24(3):218-22. doi: 10.1097/CCO.0b013e3283523c95. PMID: 22450148

Prognosis

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Respiratory Tract Cancers Collaborators
Lancet Respir Med 2021 Sep;9(9):1030-1049. Epub 2021 Aug 16 doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
The matrix metalloproteinase in larynx cancer.
Grzelczyk WL, Szemraj J, Józefowicz-Korczyńska M
Postepy Hig Med Dosw (Online) 2016 Dec 8;70(0):1190-1197. PMID: 28026822
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Clinical prediction guides

Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.
Hayes RB, Ahn J, Fan X, Peters BA, Ma Y, Yang L, Agalliu I, Burk RD, Ganly I, Purdue MP, Freedman ND, Gapstur SM, Pei Z
JAMA Oncol 2018 Mar 1;4(3):358-365. doi: 10.1001/jamaoncol.2017.4777. PMID: 29327043Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
The matrix metalloproteinase in larynx cancer.
Grzelczyk WL, Szemraj J, Józefowicz-Korczyńska M
Postepy Hig Med Dosw (Online) 2016 Dec 8;70(0):1190-1197. PMID: 28026822
Occupation and cancer of the larynx: a systematic review and meta-analysis.
Bayer O, Cámara R, Zeissig SR, Ressing M, Dietz A, Locati LD, Ramroth H, Singer S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):9-20. Epub 2014 Oct 14 doi: 10.1007/s00405-014-3321-y. PMID: 25311307

Recent systematic reviews

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Respiratory Tract Cancers Collaborators
Lancet Respir Med 2021 Sep;9(9):1030-1049. Epub 2021 Aug 16 doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511Free PMC Article
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
Laryngeal chondrosarcoma: A systematic review of 592 cases.
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822
Occupation and cancer of the larynx: a systematic review and meta-analysis.
Bayer O, Cámara R, Zeissig SR, Ressing M, Dietz A, Locati LD, Ramroth H, Singer S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):9-20. Epub 2014 Oct 14 doi: 10.1007/s00405-014-3321-y. PMID: 25311307
Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis.
Wagner M, Bolm-Audorff U, Hegewald J, Fishta A, Schlattmann P, Schmitt J, Seidler A
Occup Environ Med 2015 Mar;72(3):226-33. Epub 2014 Nov 14 doi: 10.1136/oemed-2014-102317. PMID: 25398415

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

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