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Rectal Anastomotic Leakage

MedGen UID:
305631
•Concept ID:
C1698511
•
Pathologic Function

Definition

Leakage due to breakdown of a rectal anastomosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Anastomotic Leakage

Professional guidelines

PubMed

Risk assessment of rectal anastomotic leakage (RAREAL) after DIXON in non-emergency patients with rectal cancer.
Zheng XC, Su JB, Zheng JJ
BMC Gastroenterol 2023 Oct 3;23(1):343. doi: 10.1186/s12876-023-02982-2. PMID: 37789294Free PMC Article
Endoscopic vacuum therapy for the treatment of colorectal leaks - a systematic review and meta-analysis.
Kühn F, Schardey J, Wirth U, Schiergens T, Crispin A, Beger N, Andrade D, Drefs M, Zimmermann P, Burian M, Andrassy J, Werner J
Int J Colorectal Dis 2022 Feb;37(2):283-292. Epub 2021 Nov 24 doi: 10.1007/s00384-021-04066-7. PMID: 34817647Free PMC Article
Recurrence of rectal anastomotic leakage following stoma closure: assessment of risk factors.
Kitaguchi D, Nishizawa Y, Sasaki T, Tsukada Y, Ikeda K, Ito M
Colorectal Dis 2019 Nov;21(11):1304-1311. Epub 2019 Jul 7 doi: 10.1111/codi.14728. PMID: 31199545

Recent clinical studies

Etiology

Risk assessment of rectal anastomotic leakage (RAREAL) after DIXON in non-emergency patients with rectal cancer.
Zheng XC, Su JB, Zheng JJ
BMC Gastroenterol 2023 Oct 3;23(1):343. doi: 10.1186/s12876-023-02982-2. PMID: 37789294Free PMC Article
OVA-LEAK: Prognostic score for colo-rectal anastomotic leakage in patients undergoing ovarian cancer surgery.
Lago V, Segarra-Vidal B, Cappucio S, Angeles MA, Fotopoulou C, Muallem MZ, Manzanedo I, Iglesias JLS, Chacón E, Padilla-Iserte P, Fagotti A, Ferron G, Kluge L, Vargiu V, Del M, Scambia G, Minig L, Tejerizo Á, Segovia MG, Cascales-Campos PA; OVA-LEAK Collaborative Group, Hervás D, Domingo S
Gynecol Oncol 2022 Oct;167(1):22-27. Epub 2022 Sep 2 doi: 10.1016/j.ygyno.2022.08.004. PMID: 36058743
Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage: A critical analysis.
Vignali A, De Nardi P
World J Gastroenterol 2022 Apr 14;28(14):1394-1404. doi: 10.3748/wjg.v28.i14.1394. PMID: 35582677Free PMC Article
A trinity technique for prevention of low rectal anastomotic leakage in the robotic era.
Chang W, Liu T, Ren L, He G, Ji M, Jian M, Chen Y, Liang F, Wei Y, Xu J
Eur J Surg Oncol 2020 Oct;46(10 Pt B):e47-e54. Epub 2020 Aug 15 doi: 10.1016/j.ejso.2020.07.044. PMID: 32900608
Recurrence of rectal anastomotic leakage following stoma closure: assessment of risk factors.
Kitaguchi D, Nishizawa Y, Sasaki T, Tsukada Y, Ikeda K, Ito M
Colorectal Dis 2019 Nov;21(11):1304-1311. Epub 2019 Jul 7 doi: 10.1111/codi.14728. PMID: 31199545

Diagnosis

A Novel Fluorescence-Based Leak Test Method for Rectal Anastomoses Using Aerosolized Indocyanine Green.
Kondo A, Yokota N, Kobayashi N, Feng D, Asano E, Kumamoto K, Kobara H, Okano K
Dis Colon Rectum 2024 Jan 1;67(1):168-174. Epub 2023 Sep 25 doi: 10.1097/DCR.0000000000002897. PMID: 37787549
Risk assessment of rectal anastomotic leakage (RAREAL) after DIXON in non-emergency patients with rectal cancer.
Zheng XC, Su JB, Zheng JJ
BMC Gastroenterol 2023 Oct 3;23(1):343. doi: 10.1186/s12876-023-02982-2. PMID: 37789294Free PMC Article
OVA-LEAK: Prognostic score for colo-rectal anastomotic leakage in patients undergoing ovarian cancer surgery.
Lago V, Segarra-Vidal B, Cappucio S, Angeles MA, Fotopoulou C, Muallem MZ, Manzanedo I, Iglesias JLS, Chacón E, Padilla-Iserte P, Fagotti A, Ferron G, Kluge L, Vargiu V, Del M, Scambia G, Minig L, Tejerizo Á, Segovia MG, Cascales-Campos PA; OVA-LEAK Collaborative Group, Hervás D, Domingo S
Gynecol Oncol 2022 Oct;167(1):22-27. Epub 2022 Sep 2 doi: 10.1016/j.ygyno.2022.08.004. PMID: 36058743
Predicting Value of Serum Procalcitonin, C-Reactive Protein, Drain Fluid Culture, Drain Fluid Interleukin-6, and Tumor Necrosis Factor-α Levels in Anastomotic Leakage after Rectal Resection.
Bilgin IA, Hatipoglu E, Aghayeva A, Arikan AE, Incir S, Mamal Torun M, Dirican A, Erguney S
Surg Infect (Larchmt) 2017 Apr;18(3):350-356. Epub 2017 Feb 23 doi: 10.1089/sur.2016.222. PMID: 28394749
Colo-rectal anastomotic leakage often masquerades as a cardiac complication.
Sutton CD, Marshall LJ, Williams N, Berry DP, Thomas WM, Kelly MJ
Colorectal Dis 2004 Jan;6(1):21-2. doi: 10.1111/j.1463-1318.2004.00574.x. PMID: 14692947

Therapy

Risk assessment of rectal anastomotic leakage (RAREAL) after DIXON in non-emergency patients with rectal cancer.
Zheng XC, Su JB, Zheng JJ
BMC Gastroenterol 2023 Oct 3;23(1):343. doi: 10.1186/s12876-023-02982-2. PMID: 37789294Free PMC Article
OVA-LEAK: Prognostic score for colo-rectal anastomotic leakage in patients undergoing ovarian cancer surgery.
Lago V, Segarra-Vidal B, Cappucio S, Angeles MA, Fotopoulou C, Muallem MZ, Manzanedo I, Iglesias JLS, Chacón E, Padilla-Iserte P, Fagotti A, Ferron G, Kluge L, Vargiu V, Del M, Scambia G, Minig L, Tejerizo Á, Segovia MG, Cascales-Campos PA; OVA-LEAK Collaborative Group, Hervás D, Domingo S
Gynecol Oncol 2022 Oct;167(1):22-27. Epub 2022 Sep 2 doi: 10.1016/j.ygyno.2022.08.004. PMID: 36058743
Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage: A critical analysis.
Vignali A, De Nardi P
World J Gastroenterol 2022 Apr 14;28(14):1394-1404. doi: 10.3748/wjg.v28.i14.1394. PMID: 35582677Free PMC Article
Recurrence of rectal anastomotic leakage following stoma closure: assessment of risk factors.
Kitaguchi D, Nishizawa Y, Sasaki T, Tsukada Y, Ikeda K, Ito M
Colorectal Dis 2019 Nov;21(11):1304-1311. Epub 2019 Jul 7 doi: 10.1111/codi.14728. PMID: 31199545
Systematic review of endoluminal vacuum-assisted therapy as salvage treatment for rectal anastomotic leakage.
Shalaby M, Emile S, Elfeki H, Sakr A, Wexner SD, Sileri P
BJS Open 2019 Apr;3(2):153-160. Epub 2018 Dec 26 doi: 10.1002/bjs5.50124. PMID: 30957061Free PMC Article

Prognosis

OVA-LEAK: Prognostic score for colo-rectal anastomotic leakage in patients undergoing ovarian cancer surgery.
Lago V, Segarra-Vidal B, Cappucio S, Angeles MA, Fotopoulou C, Muallem MZ, Manzanedo I, Iglesias JLS, Chacón E, Padilla-Iserte P, Fagotti A, Ferron G, Kluge L, Vargiu V, Del M, Scambia G, Minig L, Tejerizo Á, Segovia MG, Cascales-Campos PA; OVA-LEAK Collaborative Group, Hervás D, Domingo S
Gynecol Oncol 2022 Oct;167(1):22-27. Epub 2022 Sep 2 doi: 10.1016/j.ygyno.2022.08.004. PMID: 36058743
Recurrence of rectal anastomotic leakage following stoma closure: assessment of risk factors.
Kitaguchi D, Nishizawa Y, Sasaki T, Tsukada Y, Ikeda K, Ito M
Colorectal Dis 2019 Nov;21(11):1304-1311. Epub 2019 Jul 7 doi: 10.1111/codi.14728. PMID: 31199545
Predicting Value of Serum Procalcitonin, C-Reactive Protein, Drain Fluid Culture, Drain Fluid Interleukin-6, and Tumor Necrosis Factor-α Levels in Anastomotic Leakage after Rectal Resection.
Bilgin IA, Hatipoglu E, Aghayeva A, Arikan AE, Incir S, Mamal Torun M, Dirican A, Erguney S
Surg Infect (Larchmt) 2017 Apr;18(3):350-356. Epub 2017 Feb 23 doi: 10.1089/sur.2016.222. PMID: 28394749

Clinical prediction guides

A Novel Fluorescence-Based Leak Test Method for Rectal Anastomoses Using Aerosolized Indocyanine Green.
Kondo A, Yokota N, Kobayashi N, Feng D, Asano E, Kumamoto K, Kobara H, Okano K
Dis Colon Rectum 2024 Jan 1;67(1):168-174. Epub 2023 Sep 25 doi: 10.1097/DCR.0000000000002897. PMID: 37787549
Risk assessment of rectal anastomotic leakage (RAREAL) after DIXON in non-emergency patients with rectal cancer.
Zheng XC, Su JB, Zheng JJ
BMC Gastroenterol 2023 Oct 3;23(1):343. doi: 10.1186/s12876-023-02982-2. PMID: 37789294Free PMC Article
OVA-LEAK: Prognostic score for colo-rectal anastomotic leakage in patients undergoing ovarian cancer surgery.
Lago V, Segarra-Vidal B, Cappucio S, Angeles MA, Fotopoulou C, Muallem MZ, Manzanedo I, Iglesias JLS, Chacón E, Padilla-Iserte P, Fagotti A, Ferron G, Kluge L, Vargiu V, Del M, Scambia G, Minig L, Tejerizo Á, Segovia MG, Cascales-Campos PA; OVA-LEAK Collaborative Group, Hervás D, Domingo S
Gynecol Oncol 2022 Oct;167(1):22-27. Epub 2022 Sep 2 doi: 10.1016/j.ygyno.2022.08.004. PMID: 36058743
Systematic review of endoluminal vacuum-assisted therapy as salvage treatment for rectal anastomotic leakage.
Shalaby M, Emile S, Elfeki H, Sakr A, Wexner SD, Sileri P
BJS Open 2019 Apr;3(2):153-160. Epub 2018 Dec 26 doi: 10.1002/bjs5.50124. PMID: 30957061Free PMC Article
Predicting Value of Serum Procalcitonin, C-Reactive Protein, Drain Fluid Culture, Drain Fluid Interleukin-6, and Tumor Necrosis Factor-α Levels in Anastomotic Leakage after Rectal Resection.
Bilgin IA, Hatipoglu E, Aghayeva A, Arikan AE, Incir S, Mamal Torun M, Dirican A, Erguney S
Surg Infect (Larchmt) 2017 Apr;18(3):350-356. Epub 2017 Feb 23 doi: 10.1089/sur.2016.222. PMID: 28394749

Recent systematic reviews

Systematic review of endoluminal vacuum-assisted therapy as salvage treatment for rectal anastomotic leakage.
Shalaby M, Emile S, Elfeki H, Sakr A, Wexner SD, Sileri P
BJS Open 2019 Apr;3(2):153-160. Epub 2018 Dec 26 doi: 10.1002/bjs5.50124. PMID: 30957061Free PMC Article

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