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Gastrointestinal anastomotic leak

MedGen UID:
87421
•Concept ID:
C0341562
•
Finding
Synonyms: Digestive System Anastomotic Leakage; Gastrointestinal System Anastomotic Leakage; Leaking gastrointestinal anastomosis
SNOMED CT: Leaking gastrointestinal anastomosis (236085004); Gastrointestinal anastomotic leak (236085004)

Definition

Leakage due to breakdown of a gastrointestinal anastomosis. [from NCI]

Professional guidelines

PubMed

Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage.
Chadi SA, Fingerhut A, Berho M, DeMeester SR, Fleshman JW, Hyman NH, Margolin DA, Martz JE, McLemore EC, Molena D, Newman MI, Rafferty JF, Safar B, Senagore AJ, Zmora O, Wexner SD
J Gastrointest Surg 2016 Dec;20(12):2035-2051. Epub 2016 Sep 16 doi: 10.1007/s11605-016-3255-3. PMID: 27638764
Endoscopic Treatment of Gastrointestinal Perforations, Leaks, and Fistulae.
Rustagi T, McCarty TR, Aslanian HR
J Clin Gastroenterol 2015 Nov-Dec;49(10):804-9. doi: 10.1097/MCG.0000000000000409. PMID: 26325190
Endoscopic Management of Gastrointestinal Leaks and Fistulae.
Willingham FF, Buscaglia JM
Clin Gastroenterol Hepatol 2015 Oct;13(10):1714-21. Epub 2015 Feb 16 doi: 10.1016/j.cgh.2015.02.010. PMID: 25697628

Recent clinical studies

Etiology

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Epidural Local Anesthetics Versus Opioid-Based Analgesic Regimens for Postoperative Gastrointestinal Paralysis, Vomiting, and Pain After Abdominal Surgery: A Cochrane Review.
Guay J, Nishimori M, Kopp SL
Anesth Analg 2016 Dec;123(6):1591-1602. doi: 10.1213/ANE.0000000000001628. PMID: 27870743
Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery.
Guay J, Nishimori M, Kopp S
Cochrane Database Syst Rev 2016 Jul 16;7(7):CD001893. doi: 10.1002/14651858.CD001893.pub2. PMID: 27419911Free PMC Article
Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak.
Felder SI, Barmparas G, Murrell Z, Fleshner P
Am J Surg 2014 Jul;208(1):58-64. Epub 2014 Jan 4 doi: 10.1016/j.amjsurg.2013.08.050. PMID: 24476970

Diagnosis

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097
Anastomotic leaks: what is the best diagnostic imaging study?
Nicksa GA, Dring RV, Johnson KH, Sardella WV, Vignati PV, Cohen JL
Dis Colon Rectum 2007 Feb;50(2):197-203. doi: 10.1007/s10350-006-0708-x. PMID: 17164970

Therapy

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Epidural Local Anesthetics Versus Opioid-Based Analgesic Regimens for Postoperative Gastrointestinal Paralysis, Vomiting, and Pain After Abdominal Surgery: A Cochrane Review.
Guay J, Nishimori M, Kopp SL
Anesth Analg 2016 Dec;123(6):1591-1602. doi: 10.1213/ANE.0000000000001628. PMID: 27870743
Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery.
Guay J, Nishimori M, Kopp S
Cochrane Database Syst Rev 2016 Jul 16;7(7):CD001893. doi: 10.1002/14651858.CD001893.pub2. PMID: 27419911Free PMC Article
Endoscopic treatment of a large upper gastrointestinal anastomotic leak using a prolene plug and cyanoacrylate.
Disibeyaz S, Parlak E, Koksal AS, Cicek B, Koc U, Sahin B
Endoscopy 2005 Oct;37(10):1032-3. doi: 10.1055/s-2005-870439. PMID: 16189781

Prognosis

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak.
Felder SI, Barmparas G, Murrell Z, Fleshner P
Am J Surg 2014 Jul;208(1):58-64. Epub 2014 Jan 4 doi: 10.1016/j.amjsurg.2013.08.050. PMID: 24476970
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097
Endoscopic treatment of a large upper gastrointestinal anastomotic leak using a prolene plug and cyanoacrylate.
Disibeyaz S, Parlak E, Koksal AS, Cicek B, Koc U, Sahin B
Endoscopy 2005 Oct;37(10):1032-3. doi: 10.1055/s-2005-870439. PMID: 16189781

Clinical prediction guides

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
Epidural Local Anesthetics Versus Opioid-Based Analgesic Regimens for Postoperative Gastrointestinal Paralysis, Vomiting, and Pain After Abdominal Surgery: A Cochrane Review.
Guay J, Nishimori M, Kopp SL
Anesth Analg 2016 Dec;123(6):1591-1602. doi: 10.1213/ANE.0000000000001628. PMID: 27870743
Image-guided percutaneous drainage vs. surgical repair of gastrointestinal anastomotic leaks: is there a difference in hospital course or hospitalization cost?
Burke LM, Bashir MR, Gardner CS, Parsee AA, Marin D, Vermess D, Bhattacharya SD, Thacker JK, Jaffe TA
Abdom Imaging 2015 Jun;40(5):1279-84. doi: 10.1007/s00261-014-0265-z. PMID: 25294007
Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak.
Felder SI, Barmparas G, Murrell Z, Fleshner P
Am J Surg 2014 Jul;208(1):58-64. Epub 2014 Jan 4 doi: 10.1016/j.amjsurg.2013.08.050. PMID: 24476970
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097

Recent systematic reviews

Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery.
Guay J, Nishimori M, Kopp S
Cochrane Database Syst Rev 2016 Jul 16;7(7):CD001893. doi: 10.1002/14651858.CD001893.pub2. PMID: 27419911Free PMC Article
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097

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