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Drug dependence

MedGen UID:
307144
Concept ID:
C1510472
Mental or Behavioral Dysfunction
Synonyms: Addiction, Drug; Dependence, Drug; Drug Addiction; Drug Dependence
SNOMED CT: Dependent drug abuse (6525002); Drug addiction (6525002); Psychoactive substance dependence (2403008)
 
HPO: HP:0033511
Monarch Initiative: MONDO:0005303

Definition

Chronic compulsive drug seeking and continued use despite harmful consequences. [from HPO]

Professional guidelines

PubMed

Jain R, Jain S, Montano CB
Prim Care Companion CNS Disord 2017 Sep 7;19(5) doi: 10.4088/PCC.17nr02153. PMID: 28906602
Yau YH, Potenza MN
Harv Rev Psychiatry 2015 Mar-Apr;23(2):134-46. doi: 10.1097/HRP.0000000000000051. PMID: 25747926Free PMC Article
McLellan AT, Lewis DC, O'Brien CP, Kleber HD
JAMA 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800

Recent clinical studies

Etiology

Su S, Zhao Y, Zeng N, Liu X, Zheng Y, Sun J, Zhong Y, Wu S, Ni S, Gong Y, Zhang Z, Gao N, Yuan K, Yan W, Shi L, Ravindran AV, Kosten T, Shi J, Bao Y, Lu L
Mol Psychiatry 2023 Oct;28(10):4056-4069. Epub 2023 Jul 25 doi: 10.1038/s41380-023-02171-3. PMID: 37491461
Yue JL, Chang XW, Zheng JW, Shi L, Xiang YJ, Que JY, Yuan K, Deng JH, Teng T, Li YY, Sun W, Sun HQ, Vitiello MV, Tang XD, Zhou XY, Bao YP, Shi J, Lu L
Sleep Med Rev 2023 Apr;68:101746. Epub 2023 Jan 14 doi: 10.1016/j.smrv.2023.101746. PMID: 36701954
Meng SQ, Cheng JL, Li YY, Yang XQ, Zheng JW, Chang XW, Shi Y, Chen Y, Lu L, Sun Y, Bao YP, Shi J
Clin Psychol Rev 2022 Mar;92:102128. Epub 2022 Jan 25 doi: 10.1016/j.cpr.2022.102128. PMID: 35150965
Zheng YB, Shi L, Zhu XM, Bao YP, Bai LJ, Li JQ, Liu JJ, Han Y, Shi J, Lu L
Neurosci Biobehav Rev 2021 Aug;127:296-306. Epub 2021 Apr 29 doi: 10.1016/j.neubiorev.2021.04.031. PMID: 33933505
Lu Q, Zhang X, Wang Y, Li J, Xu Y, Song X, Su S, Zhu X, Vitiello MV, Shi J, Bao Y, Lu L
Sleep Med Rev 2021 Aug;58:101436. Epub 2021 Jan 22 doi: 10.1016/j.smrv.2021.101436. PMID: 33571887

Diagnosis

Sun J, Dong QX, Wang SW, Zheng YB, Liu XX, Lu TS, Yuan K, Shi J, Hu B, Lu L, Han Y
Asian J Psychiatr 2023 Sep;87:103705. Epub 2023 Jul 22 doi: 10.1016/j.ajp.2023.103705. PMID: 37506575
Yue JL, Chang XW, Zheng JW, Shi L, Xiang YJ, Que JY, Yuan K, Deng JH, Teng T, Li YY, Sun W, Sun HQ, Vitiello MV, Tang XD, Zhou XY, Bao YP, Shi J, Lu L
Sleep Med Rev 2023 Apr;68:101746. Epub 2023 Jan 14 doi: 10.1016/j.smrv.2023.101746. PMID: 36701954
Jain R, Jain S, Montano CB
Prim Care Companion CNS Disord 2017 Sep 7;19(5) doi: 10.4088/PCC.17nr02153. PMID: 28906602
Yau YH, Potenza MN
Harv Rev Psychiatry 2015 Mar-Apr;23(2):134-46. doi: 10.1097/HRP.0000000000000051. PMID: 25747926Free PMC Article
McLellan AT, Lewis DC, O'Brien CP, Kleber HD
JAMA 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800

Therapy

Zheng YB, Zeng N, Yuan K, Tian SS, Yang YB, Gao N, Chen X, Zhang AY, Kondratiuk AL, Shi PP, Zhang F, Sun J, Yue JL, Lin X, Shi L, Lalvani A, Shi J, Bao YP, Lu L
J Infect Public Health 2023 May;16(5):660-672. Epub 2023 Mar 7 doi: 10.1016/j.jiph.2023.03.005. PMID: 36931142Free PMC Article
Yue JL, Chang XW, Zheng JW, Shi L, Xiang YJ, Que JY, Yuan K, Deng JH, Teng T, Li YY, Sun W, Sun HQ, Vitiello MV, Tang XD, Zhou XY, Bao YP, Shi J, Lu L
Sleep Med Rev 2023 Apr;68:101746. Epub 2023 Jan 14 doi: 10.1016/j.smrv.2023.101746. PMID: 36701954
Lu Q, Zhang X, Wang Y, Li J, Xu Y, Song X, Su S, Zhu X, Vitiello MV, Shi J, Bao Y, Lu L
Sleep Med Rev 2021 Aug;58:101436. Epub 2021 Jan 22 doi: 10.1016/j.smrv.2021.101436. PMID: 33571887
Han Y, Yuan K, Zheng Y, Lu L
Neurosci Bull 2020 Apr;36(4):432-448. Epub 2019 Nov 28 doi: 10.1007/s12264-019-00447-9. PMID: 31782044Free PMC Article
Gouzoulis-Mayfrank E, Härtel-Petri R, Hamdorf W, Havemann-Reinecke U, Mühlig S, Wodarz N
Dtsch Arztebl Int 2017 Jun 30;114(26):455-461. doi: 10.3238/arztebl.2017.0455. PMID: 28705298Free PMC Article

Prognosis

Sun J, Dong QX, Wang SW, Zheng YB, Liu XX, Lu TS, Yuan K, Shi J, Hu B, Lu L, Han Y
Asian J Psychiatr 2023 Sep;87:103705. Epub 2023 Jul 22 doi: 10.1016/j.ajp.2023.103705. PMID: 37506575
Zheng YB, Shi L, Zhu XM, Bao YP, Bai LJ, Li JQ, Liu JJ, Han Y, Shi J, Lu L
Neurosci Biobehav Rev 2021 Aug;127:296-306. Epub 2021 Apr 29 doi: 10.1016/j.neubiorev.2021.04.031. PMID: 33933505
Cao KX, Ma ML, Wang CZ, Iqbal J, Si JJ, Xue YX, Yang JL
Neuropharmacology 2021 Oct 1;197:108574. Epub 2021 Apr 22 doi: 10.1016/j.neuropharm.2021.108574. PMID: 33894219
Wang YH, Li JQ, Shi JF, Que JY, Liu JJ, Lappin JM, Leung J, Ravindran AV, Chen WQ, Qiao YL, Shi J, Lu L, Bao YP
Mol Psychiatry 2020 Jul;25(7):1487-1499. Epub 2019 Nov 19 doi: 10.1038/s41380-019-0595-x. PMID: 31745237
McLellan AT, Lewis DC, O'Brien CP, Kleber HD
JAMA 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800

Clinical prediction guides

Zeng N, Zhao YM, Yan W, Li C, Lu QD, Liu L, Ni SY, Mei H, Yuan K, Shi L, Li P, Fan TT, Yuan JL, Vitiello MV, Kosten T, Kondratiuk AL, Sun HQ, Tang XD, Liu MY, Lalvani A, Shi J, Bao YP, Lu L
Mol Psychiatry 2023 Jan;28(1):423-433. Epub 2022 Jun 6 doi: 10.1038/s41380-022-01614-7. PMID: 35668159Free PMC Article
Zheng YB, Shi L, Zhu XM, Bao YP, Bai LJ, Li JQ, Liu JJ, Han Y, Shi J, Lu L
Neurosci Biobehav Rev 2021 Aug;127:296-306. Epub 2021 Apr 29 doi: 10.1016/j.neubiorev.2021.04.031. PMID: 33933505
Cao KX, Ma ML, Wang CZ, Iqbal J, Si JJ, Xue YX, Yang JL
Neuropharmacology 2021 Oct 1;197:108574. Epub 2021 Apr 22 doi: 10.1016/j.neuropharm.2021.108574. PMID: 33894219
Lu Q, Zhang X, Wang Y, Li J, Xu Y, Song X, Su S, Zhu X, Vitiello MV, Shi J, Bao Y, Lu L
Sleep Med Rev 2021 Aug;58:101436. Epub 2021 Jan 22 doi: 10.1016/j.smrv.2021.101436. PMID: 33571887
Sun YK, Sun Y, Lin X, Lu L, Shi J
Adv Exp Med Biol 2017;1010:73-89. doi: 10.1007/978-981-10-5562-1_5. PMID: 29098669

Recent systematic reviews

Yue JL, Chang XW, Zheng JW, Shi L, Xiang YJ, Que JY, Yuan K, Deng JH, Teng T, Li YY, Sun W, Sun HQ, Vitiello MV, Tang XD, Zhou XY, Bao YP, Shi J, Lu L
Sleep Med Rev 2023 Apr;68:101746. Epub 2023 Jan 14 doi: 10.1016/j.smrv.2023.101746. PMID: 36701954
Meng SQ, Cheng JL, Li YY, Yang XQ, Zheng JW, Chang XW, Shi Y, Chen Y, Lu L, Sun Y, Bao YP, Shi J
Clin Psychol Rev 2022 Mar;92:102128. Epub 2022 Jan 25 doi: 10.1016/j.cpr.2022.102128. PMID: 35150965
Zheng YB, Shi L, Zhu XM, Bao YP, Bai LJ, Li JQ, Liu JJ, Han Y, Shi J, Lu L
Neurosci Biobehav Rev 2021 Aug;127:296-306. Epub 2021 Apr 29 doi: 10.1016/j.neubiorev.2021.04.031. PMID: 33933505
Lu Q, Zhang X, Wang Y, Li J, Xu Y, Song X, Su S, Zhu X, Vitiello MV, Shi J, Bao Y, Lu L
Sleep Med Rev 2021 Aug;58:101436. Epub 2021 Jan 22 doi: 10.1016/j.smrv.2021.101436. PMID: 33571887
Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L
Sleep Med Rev 2018 Aug;40:4-16. Epub 2017 Jul 6 doi: 10.1016/j.smrv.2017.06.010. PMID: 28890168

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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