U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Opiate dependence

MedGen UID:
99372
•Concept ID:
C0524662
•
Mental or Behavioral Dysfunction
Synonym: Addictive opioid use
SNOMED CT: Opioid dependence (75544000); Narcotism (75544000)
 
HPO: HP:0033515
Monarch Initiative: MONDO:0005530

Definition

Addiction to opioids. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOpiate dependence

Professional guidelines

PubMed

Treatment of insomnia - effect of trazodone and hypnotics on sleep.
Wichniak A, Wierzbicka AE, Jarema M
Psychiatr Pol 2021 Aug 31;55(4):743-755. doi: 10.12740/PP/125650. PMID: 34994734
Retention in medication-assisted treatment for opiate dependence: A systematic review.
Timko C, Schultz NR, Cucciare MA, Vittorio L, Garrison-Diehn C
J Addict Dis 2016;35(1):22-35. Epub 2015 Oct 14 doi: 10.1080/10550887.2016.1100960. PMID: 26467975Free PMC Article
Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.
McLellan AT, Lewis DC, O'Brien CP, Kleber HD
JAMA 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800

Recent clinical studies

Etiology

Treatment of insomnia - effect of trazodone and hypnotics on sleep.
Wichniak A, Wierzbicka AE, Jarema M
Psychiatr Pol 2021 Aug 31;55(4):743-755. doi: 10.12740/PP/125650. PMID: 34994734
Breastfeeding support and opiate dependence: A think aloud study.
MacVicar S PhD, Humphrey T PhD, Forbes-McKay KE PhD
Midwifery 2017 Jul;50:239-245. Epub 2017 Apr 27 doi: 10.1016/j.midw.2017.04.013. PMID: 28494389
Psychosocial treatment for opiate abuse and dependence.
Mayet S, Farrell M, Ferri M, Amato L, Davoli M
Cochrane Database Syst Rev 2005 Jan 25;(1):CD004330. doi: 10.1002/14651858.CD004330.pub2. PMID: 15744796
Antidepressants for cocaine dependence.
Lima MS, Reisser AA, Soares BG, Farrell M
Cochrane Database Syst Rev 2001;(4):CD002950. doi: 10.1002/14651858.CD002950. PMID: 11687168
Opiates and infection.
Risdahl JM, Khanna KV, Peterson PK, Molitor TW
J Neuroimmunol 1998 Mar 15;83(1-2):4-18. doi: 10.1016/s0165-5728(97)00216-6. PMID: 9610668

Diagnosis

Opiate dependence in schizophrenia: case presentation and literature review.
Kern AM, Akerman SC, Nordstrom BR
J Dual Diagn 2014;10(1):52-7. doi: 10.1080/15504263.2013.867199. PMID: 25392062
Psychosocial treatment for opiate abuse and dependence.
Mayet S, Farrell M, Ferri M, Amato L, Davoli M
Cochrane Database Syst Rev 2005 Jan 25;(1):CD004330. doi: 10.1002/14651858.CD004330.pub2. PMID: 15744796
Antidepressants for cocaine dependence.
Lima MS, Reisser AA, Soares BG, Farrell M
Cochrane Database Syst Rev 2001;(4):CD002950. doi: 10.1002/14651858.CD002950. PMID: 11687168
Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.
McLellan AT, Lewis DC, O'Brien CP, Kleber HD
JAMA 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800
Drugs of abuse--opiates.
Ling W, Wesson DR
West J Med 1990 May;152(5):565-72. PMID: 2161588Free PMC Article

Therapy

Treatment of insomnia - effect of trazodone and hypnotics on sleep.
Wichniak A, Wierzbicka AE, Jarema M
Psychiatr Pol 2021 Aug 31;55(4):743-755. doi: 10.12740/PP/125650. PMID: 34994734
Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials.
Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S
J Ethnopharmacol 2013 Dec 12;150(3):791-804. Epub 2013 Oct 17 doi: 10.1016/j.jep.2013.09.047. PMID: 24140586
Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.
Scavone JL, Sterling RC, Van Bockstaele EJ
Neuroscience 2013 Sep 17;248:637-54. Epub 2013 Apr 24 doi: 10.1016/j.neuroscience.2013.04.034. PMID: 23624062Free PMC Article
Opiate withdrawal.
Farrell M
Addiction 1994 Nov;89(11):1471-5. doi: 10.1111/j.1360-0443.1994.tb03745.x. PMID: 7841858
Drugs of abuse--opiates.
Ling W, Wesson DR
West J Med 1990 May;152(5):565-72. PMID: 2161588Free PMC Article

Prognosis

Treatment of insomnia - effect of trazodone and hypnotics on sleep.
Wichniak A, Wierzbicka AE, Jarema M
Psychiatr Pol 2021 Aug 31;55(4):743-755. doi: 10.12740/PP/125650. PMID: 34994734
Comorbid posttraumatic stress disorder and opiate addiction: a literature review.
Fareed A, Eilender P, Haber M, Bremner J, Whitfield N, Drexler K
J Addict Dis 2013;32(2):168-79. doi: 10.1080/10550887.2013.795467. PMID: 23815424
Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.
McLellan AT, Lewis DC, O'Brien CP, Kleber HD
JAMA 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800
Opiate withdrawal.
Farrell M
Addiction 1994 Nov;89(11):1471-5. doi: 10.1111/j.1360-0443.1994.tb03745.x. PMID: 7841858
Neural mechanisms of drug reinforcement.
Koob GF
Ann N Y Acad Sci 1992 Jun 28;654:171-91. doi: 10.1111/j.1749-6632.1992.tb25966.x. PMID: 1632582

Clinical prediction guides

Male and female rats show opiate withdrawal-induced place aversion and extinction in a Y-maze paradigm.
Fournier ML, Faugere A, Barba-Vila O, Le Moine C
Behav Brain Res 2023 Feb 2;437:114122. Epub 2022 Sep 26 doi: 10.1016/j.bbr.2022.114122. PMID: 36174840
An international systematic review of smoking prevalence in addiction treatment.
Guydish J, Passalacqua E, Pagano A, Martínez C, Le T, Chun J, Tajima B, Docto L, Garina D, Delucchi K
Addiction 2016 Feb;111(2):220-30. Epub 2015 Sep 22 doi: 10.1111/add.13099. PMID: 26392127Free PMC Article
Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials.
Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S
J Ethnopharmacol 2013 Dec 12;150(3):791-804. Epub 2013 Oct 17 doi: 10.1016/j.jep.2013.09.047. PMID: 24140586
Quality of life among opiate-dependent individuals: A review of the literature.
De Maeyer J, Vanderplasschen W, Broekaert E
Int J Drug Policy 2010 Sep;21(5):364-80. Epub 2010 Feb 20 doi: 10.1016/j.drugpo.2010.01.010. PMID: 20172706
Opiate physical dependence and N-methyl-D-aspartate receptors.
Noda Y, Nabeshima T
Eur J Pharmacol 2004 Oct 1;500(1-3):121-8. doi: 10.1016/j.ejphar.2004.07.017. PMID: 15464026

Recent systematic reviews

Effects of behavioural activation on substance use and depression: a systematic review.
Martínez-Vispo C, Martínez Ú, López-Durán A, Fernández Del Río E, Becoña E
Subst Abuse Treat Prev Policy 2018 Sep 29;13(1):36. doi: 10.1186/s13011-018-0173-2. PMID: 30268136Free PMC Article
Tincture of opium for treating opioid dependence: a systematic review of safety and efficacy.
Nikoo M, Nikoo N, Anbardan SJ, Amiri A, Vogel M, Choi F, Sepehry AA, Bagheri Valoojerdi AH, Jang K, Schütz C, Akhondzadeh S, Krausz M
Addiction 2017 Mar;112(3):415-429. Epub 2016 Dec 13 doi: 10.1111/add.13628. PMID: 27740713
Retention in medication-assisted treatment for opiate dependence: A systematic review.
Timko C, Schultz NR, Cucciare MA, Vittorio L, Garrison-Diehn C
J Addict Dis 2016;35(1):22-35. Epub 2015 Oct 14 doi: 10.1080/10550887.2016.1100960. PMID: 26467975Free PMC Article
An international systematic review of smoking prevalence in addiction treatment.
Guydish J, Passalacqua E, Pagano A, Martínez C, Le T, Chun J, Tajima B, Docto L, Garina D, Delucchi K
Addiction 2016 Feb;111(2):220-30. Epub 2015 Sep 22 doi: 10.1111/add.13099. PMID: 26392127Free PMC Article
Antidepressants for cocaine dependence.
Lima MS, Reisser AA, Soares BG, Farrell M
Cochrane Database Syst Rev 2001;(4):CD002950. doi: 10.1002/14651858.CD002950. PMID: 11687168

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...